Dipeptidase 1 (Dpep1), renal dipeptidase (RDP), or microsomal dipeptidase is a zinc-dependent metalloenzyme that hydrolyses a wide range of dipeptides. It is implicated in the renal metabolism of glutathione and its conjugates. It converts leukotriene D4 to leukotriene E4 and it may play an important role in the regulation of leukotriene activity []. Renal dipeptidase seems to be evolutionary related to hypothetical proteins in the PQQ biosynthesis operons of Acinetobacter calcoaceticus and Klebsiella pneumoniae [].
