Type |
Details |
Score |
Allele |
Name: |
bridging integrator 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramalingam A |
Year: |
2007 |
Journal: |
Cell Cycle |
Title: |
Bin1 interacts with and restrains the DNA end-binding protein complex Ku. |
Volume: |
6 |
Issue: |
15 |
Pages: |
1914-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perdigão C |
Year: |
2021 |
Journal: |
J Biol Chem |
Title: |
Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling. |
Volume: |
297 |
Issue: |
3 |
Pages: |
101056 |
|
•
•
•
•
•
|
Publication |
First Author: |
Owen DJ |
Year: |
1998 |
Journal: |
EMBO J |
Title: |
Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation. |
Volume: |
17 |
Issue: |
18 |
Pages: |
5273-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nicot AS |
Year: |
2007 |
Journal: |
Nat Genet |
Title: |
Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy. |
Volume: |
39 |
Issue: |
9 |
Pages: |
1134-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Butler MH |
Year: |
1997 |
Journal: |
J Cell Biol |
Title: |
Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle. |
Volume: |
137 |
Issue: |
6 |
Pages: |
1355-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramjaun AR |
Year: |
1998 |
Journal: |
J Neurochem |
Title: |
Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites. |
Volume: |
70 |
Issue: |
6 |
Pages: |
2369-76 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Amphiphysin 2, also known as Bin1, is localized in many different tissues and may function in intracellular vesicle trafficking []. It plays a role in the organization and maintenance of the T-tubule network in skeletal muscle []. Mutations in Bin1 are associated with autosomal recessive centronuclear myopathy []. Bin1 contains an N-terminal BAR domain with an additional N-terminal amphipathic helix (an N-BAR) and a C-terminal SH3 domain.The SH3 domain of Bin1 forms transient complexes with actin, myosin filaments, and CDK5, to facilitate sarcomere organization and myofibre maturation []. It also binds dynamin and prevents its self-assembly []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the N-terminal regions of several plant transcription factors. It is classified as BES1/BZR1, a plant-specific transcription factor that cooperates with transcription factors such as BIM1 to regulate brassinosteroid-induced genes [].Proteins containing this domain are transcriptional repressors involved in controlling the response to Brassinosteroids (BRs). BRs are plant hormones that play essential roles in growth and development. BZR1 binds directly to DNA repressing the synthesis of genes involved in BR synthesis. Phosphorylation of BZR1 by BIN1 targets BZR1 to the 20S proteosome, while dephosphorylation leads to nuclear accumulation of BZR1 []. |
|
•
•
•
•
•
|
Publication |
First Author: |
He JX |
Year: |
2005 |
Journal: |
Science |
Title: |
BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses. |
Volume: |
307 |
Issue: |
5715 |
Pages: |
1634-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yin Y |
Year: |
2005 |
Journal: |
Cell |
Title: |
A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis. |
Volume: |
120 |
Issue: |
2 |
Pages: |
249-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karlina R |
Year: |
2021 |
Journal: |
Life Sci Alliance |
Title: |
Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice. |
Volume: |
4 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Posey AD Jr |
Year: |
2014 |
Journal: |
Dev Biol |
Title: |
EHD1 mediates vesicle trafficking required for normal muscle growth and transverse tubule development. |
Volume: |
387 |
Issue: |
2 |
Pages: |
179-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Demonbreun AR |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Eps 15 Homology Domain (EHD)-1 Remodels Transverse Tubules in Skeletal Muscle. |
Volume: |
10 |
Issue: |
9 |
Pages: |
e0136679 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou Y |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease. |
Volume: |
9 |
Issue: |
7 |
Pages: |
e103187 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
588
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
477
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
410
|
Fragment?: |
false |
|
•
•
•
•
•
|