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Search results 501 to 533 out of 533 for Rec8

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0.02s

Type

Details

Score

Protein

A0A2I3BS25

Organism:	Mus musculus/domesticus
Length:	160
Fragment?:	true

•

Publication

17205076 | J:159144

First Author:	Gómez R
Year:	2007
Journal:	EMBO Rep
Title:	Mammalian SGO2 appears at the inner centromere domain and redistributes depending on tension across centromeres during meiosis II and mitosis.
Volume:	8
Issue:	2
Pages:	173-80

•

Publication

32284991 | J:326154

First Author:	Zhou C
Year:	2020
Journal:	Sci Adv
Title:	The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.
Volume:	6
Issue:	15
Pages:	eaax3969

•

Protein

A2AU37

Organism:	Mus musculus/domesticus
Length:	552
Fragment?:	false

•

Protein

Q61550

Organism:	Mus musculus/domesticus
Length:	635
Fragment?:	false

•

Protein

Q3TG35

Organism:	Mus musculus/domesticus
Length:	635
Fragment?:	false

•

Protein

A1L366

Organism:	Mus musculus/domesticus
Length:	635
Fragment?:	false

•

Protein

Q3UTE4

Organism:	Mus musculus/domesticus
Length:	601
Fragment?:	true

•

Protein

A1L367

Organism:	Mus musculus/domesticus
Length:	635
Fragment?:	false

•

Protein

R4GML2

Organism:	Mus musculus/domesticus
Length:	549
Fragment?:	false

•

Publication

18987869 | -

First Author:	Rivera T
Year:	2009
Journal:	Chromosoma
Title:	Shugoshin regulates cohesion by driving relocalization of PP2A in Xenopus extracts.
Volume:	118
Issue:	2
Pages:	223-33

•

Publication

16687935 | -

First Author:	Suzuki H
Year:	2006
Journal:	Cell Cycle
Title:	Human Shugoshin mediates kinetochore-driven formation of kinetochore microtubules.
Volume:	5
Issue:	10
Pages:	1094-101

•

Publication

17322402 | -

First Author:	Kawashima SA
Year:	2007
Journal:	Genes Dev
Title:	Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres.
Volume:	21
Issue:	4
Pages:	420-35

•

Protein Domain

IPR011515 | Shugoshin_C

Type:

Domain

Description:

This entry represents the C-terminal domain of Shugoshin (Sgo1) kinetochore-attachment proteins. Shugoshin has a conserved coiled-coil N-terminal domain and a highly conserved C-terminal basic region (). Shugoshin is a crucial target of Bub1 kinase that plays a central role in chromosome cohesion during mitosis and meiosis divisions by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms [, ]. Shugoshin is thought to act by protecting Rec8 and Rad21 at the centromeres from separase degradation during anaphase I (during meiosis) so that sister chromatids remain tethered []. Shugoshin also acts as a spindle checkpoint component required for sensing tension between sister chromatids during mitosis, its degradation when they separate preventing cell cycle arrest and chromosome loss in anaphase, a time when sister chromatids are no longer under tension. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly []. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process [].

•

Protein Domain

IPR011516 | Shugoshin_N

Type:

Domain

Description:

This entry represents the N-terminal domain of Shugoshin (Sgo1) kinetochore-attachment proteins. Shugoshin has this conserved coiled-coil N-terminal domain and a highly conserved C-terminal basic region ().Shugoshin is a crucial target of Bub1 kinase that plays a central role in chromosome cohesion during mitosis and meiosis divisions by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms [, ]. Shugoshin is thought to act by protecting Rec8 and Rad21 at the centromeres from separase degradation during anaphase I (during meiosis) so that sister chromatids remain tethered []. Shugoshin also acts as a spindle checkpoint component required for sensing tension between sister chromatids during mitosis, its degradation when they separate preventing cell cycle arrest and chromosome loss in anaphase, a time when sister chromatids are no longer under tension. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly []. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process [].

•

Publication

21527826 | J:173689

First Author:	Gutiérrez-Caballero C
Year:	2011
Journal:	Cell Cycle
Title:	Identification and molecular characterization of the mammalian α-kleisin RAD21L.
Volume:	10
Issue:	9
Pages:	1477-87

•

Publication

35536551 | J:334012

First Author:	Cheng J
Year:	2022
Journal:	Cell Cycle
Title:	Knockout of cyclin B1 in granulosa cells causes female subfertility.
Volume:	21
Issue:	17
Pages:	1867-1878

•

Publication

32931493 | J:296548

First Author:	Fujiwara Y
Year:	2020
Journal:	PLoS Genet
Title:	Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase.
Volume:	16
Issue:	9
Pages:	e1009048

•

Publication

18753610 | J:145799

First Author:	Hupalowska A
Year:	2008
Journal:	Biol Reprod
Title:	Metaphase I arrest in LT/Sv mouse oocytes involves the spindle assembly checkpoint.
Volume:	79
Issue:	6
Pages:	1102-10

•

Publication

23434280 | J:199734

First Author:	Chambon JP
Year:	2013
Journal:	Curr Biol
Title:	The PP2A inhibitor I2PP2A is essential for sister chromatid segregation in oocyte meiosis II.
Volume:	23
Issue:	6
Pages:	485-90

•

Publication

25123474 | J:216178

First Author:	Yuan YF
Year:	2014
Journal:	Mol Reprod Dev
Title:	SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation.
Volume:	81
Issue:	8
Pages:	712-24

•

Publication

33721419 | J:307638

First Author:	Han F
Year:	2021
Journal:	Aging Cell
Title:	Identification of SRY-box 30 as an age-related essential gatekeeper for male germ-cell meiosis and differentiation.
Volume:	20
Issue:	5
Pages:	e13343

•

Protein

Q9CXH7

Organism:	Mus musculus/domesticus
Length:	517
Fragment?:	false

•

Protein Coding Gene

MGI:1098658 | Stag1

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein

Q6ZQJ6

Organism:	Mus musculus/domesticus
Length:	426
Fragment?:	true

•

Publication

34599968 | J:324061

First Author:	Campbell KM
Year:	2021
Journal:	J Biol Chem
Title:	Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice.
Volume:	297
Issue:	5
Pages:	101231

•

Publication

23444375 | J:200659

First Author:	Qi ST
Year:	2013
Journal:	J Cell Sci
Title:	Overexpression of SETβ, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocytes.
Volume:	126
Issue:	Pt 7
Pages:	1595-603

•

Protein Coding Gene

MGI:108016 | Rad21

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:1339795 | Smc3

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:1098583 | Stag2

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:1344345 | Smc1a

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

•

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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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