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Search results 101 to 200 out of 383 for Rictor

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Type Details Score
Publication
First Author: Canaud G
Year: 2013
Journal: Nat Med
Title: AKT2 is essential to maintain podocyte viability and function during chronic kidney disease.
Volume: 19
Issue: 10
Pages: 1288-96
Publication
First Author: Chen J
Year: 2015
Journal: J Bone Miner Res
Title: mTORC2 signaling promotes skeletal growth and bone formation in mice.
Volume: 30
Issue: 2
Pages: 369-78
Publication
First Author: Armour EA
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules.
Volume: 303
Issue: 4
Pages: F584-92
Publication
First Author: Zhao X
Year: 2014
Journal: Mol Cell Biol
Title: Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.
Volume: 34
Issue: 11
Pages: 1966-75
Publication
First Author: Shende P
Year: 2016
Journal: Cardiovasc Res
Title: Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy.
Volume: 109
Issue: 1
Pages: 103-14
Publication
First Author: Drägert K
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue.
Volume: 473
Issue: 1
Pages: 317-322
Publication
First Author: Lamming DW
Year: 2014
Journal: Aging Cell
Title: Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.
Volume: 13
Issue: 5
Pages: 911-7
Publication
First Author: Kaur S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses.
Volume: 109
Issue: 20
Pages: 7723-8
Publication
First Author: Hresko RC
Year: 2005
Journal: J Biol Chem
Title: mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.
Volume: 280
Issue: 49
Pages: 40406-16
Publication  
First Author: Ma S
Year: 2015
Journal: Exp Eye Res
Title: Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival.
Volume: 135
Pages: 1-13
Publication
First Author: Chen CJ
Year: 2019
Journal: Nat Med
Title: Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.
Volume: 25
Issue: 11
Pages: 1684-1690
Publication
First Author: Sampson LL
Year: 2016
Journal: FASEB J
Title: mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice.
Volume: 30
Issue: 3
Pages: 1263-75
Publication  
First Author: Hiraiwa M
Year: 2019
Journal: Front Pharmacol
Title: mTORC1 Activation in Osteoclasts Prevents Bone Loss in a Mouse Model of Osteoporosis.
Volume: 10
Pages: 684
Publication  
First Author: Chen W
Year: 2016
Journal: eNeuro
Title: Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion.
Volume: 3
Issue: 6
Publication
First Author: Yang T
Year: 2016
Journal: Cell Mol Immunol
Title: TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway.
Volume: 13
Issue: 5
Pages: 640-50
Publication
First Author: Gu Y
Year: 2011
Journal: Diabetes
Title: Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size.
Volume: 60
Issue: 3
Pages: 827-37
Publication
First Author: Patursky-Polischuk I
Year: 2009
Journal: Mol Cell Biol
Title: The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.
Volume: 29
Issue: 3
Pages: 640-9
Publication
First Author: Kalim KW
Year: 2017
Journal: PLoS One
Title: mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity.
Volume: 12
Issue: 8
Pages: e0183266
Publication
First Author: García-Martínez JM
Year: 2008
Journal: Biochem J
Title: mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
Volume: 416
Issue: 3
Pages: 375-85
Publication
First Author: Pearce LR
Year: 2011
Journal: Biochem J
Title: Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.
Volume: 436
Issue: 1
Pages: 169-79
Publication
First Author: Liu Q
Year: 2022
Journal: Cell Death Dis
Title: IL-1β-activated mTORC2 promotes accumulation of IFN-γ+ γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis.
Volume: 13
Issue: 4
Pages: 289
Publication  
First Author: Nie X
Year: 2021
Journal: Dev Biol
Title: mTOR deletion in neural crest cells disrupts cardiac outflow tract remodeling and causes a spectrum of cardiac defects through the mTORC1 pathway.
Volume: 477
Pages: 241-250
Publication
First Author: Nie X
Year: 2018
Journal: PLoS Genet
Title: mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development.
Volume: 14
Issue: 7
Pages: e1007491
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Van de Velde LA
Year: 2016
Journal: J Biol Chem
Title: Proliferating Helper T Cells Require Rictor/mTORC2 Complex to Integrate Signals from Limiting Environmental Amino Acids.
Volume: 291
Issue: 50
Pages: 25815-25822
Publication
First Author: Dadalko OI
Year: 2015
Journal: J Neurosci
Title: mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neurotransmission.
Volume: 35
Issue: 23
Pages: 8843-54
Publication  
First Author: Martinez N
Year: 2019
Journal: EBioMedicine
Title: mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis.
Volume: 45
Pages: 314-327
Publication
First Author: Grahammer F
Year: 2016
Journal: J Clin Invest
Title: mTORC2 critically regulates renal potassium handling.
Volume: 126
Issue: 5
Pages: 1773-82
Publication
First Author: Wang Y
Year: 2022
Journal: Clin Cancer Res
Title: Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity.
Volume: 28
Issue: 2
Pages: 414-424
Publication
First Author: Suryawanshi RK
Year: 2021
Journal: Nat Commun
Title: mTORC2 confers neuroprotection and potentiates immunity during virus infection.
Volume: 12
Issue: 1
Pages: 6020
Publication
First Author: Shimobayashi M
Year: 2018
Journal: J Clin Invest
Title: Insulin resistance causes inflammation in adipose tissue.
Volume: 128
Issue: 4
Pages: 1538-1550
GXD Expression    
Probe: MGI:5304388
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304574
Age: postnatal
Image: 5
Specimen Label: Normal1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5304388
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304574
Age: postnatal
Image: 5
Specimen Label: Normal2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5304388
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304574
Age: postnatal
Image: 5
Specimen Label: Normal3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5304388
Assay Type: Western blot
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5304574
Age: postnatal
Image: 5
Specimen Label: Normal4
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6754092
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:6754099
Age: postnatal adult
Specimen Label: O
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6754092
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:6754099
Age: embryonic day 0.5
Specimen Label: 1C
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6754092
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:6754099
Age: embryonic day 1.0
Specimen Label: 2C
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6754092
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:6754099
Age: embryonic day 2.0
Specimen Label: 4C
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6754092
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:6754099
Age: embryonic day 2.5
Specimen Label: 8C
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6754092
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:6754099
Age: embryonic day 3.0
Specimen Label: MO
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6754092
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6754099
Age: embryonic day 3.5
Specimen Label: BL
Detected: true
Specimen Num: 7
Publication
First Author: Ruiz A
Year: 2018
Journal: Sci Rep
Title: Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance.
Volume: 8
Issue: 1
Pages: 636
Publication
First Author: Jacinto E
Year: 2006
Journal: Cell
Title: SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Volume: 127
Issue: 1
Pages: 125-37
Publication
First Author: Heikamp EB
Year: 2014
Journal: Nat Immunol
Title: The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
Volume: 15
Issue: 5
Pages: 457-64
Publication
First Author: Wang Y
Year: 2022
Journal: Nat Immunol
Title: The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis.
Volume: 23
Issue: 2
Pages: 303-317
Publication
First Author: Oh MH
Year: 2017
Journal: Cell Rep
Title: mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages.
Volume: 20
Issue: 10
Pages: 2439-2454
Publication
First Author: Kim CS
Year: 2020
Journal: Cell Metab
Title: Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle.
Volume: 32
Issue: 4
Pages: 629-642.e8
Publication
First Author: Hu T
Year: 2017
Journal: Sci Rep
Title: PDK1 plays a vital role on hematopoietic stem cell function.
Volume: 7
Issue: 1
Pages: 4943
Publication  
First Author: Bhat N
Year: 2022
Journal: J Clin Invest
Title: Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.
Volume: 132
Issue: 3
Publication
First Author: Zou Z
Year: 2015
Journal: J Cell Biol
Title: mTORC2 promotes cell survival through c-Myc-dependent up-regulation of E2F1.
Volume: 211
Issue: 1
Pages: 105-22
Publication
First Author: Zhou F
Year: 2016
Journal: Nature
Title: Tracing haematopoietic stem cell formation at single-cell resolution.
Volume: 533
Issue: 7604
Pages: 487-92
Publication
First Author: Najafov A
Year: 2012
Journal: Biochem J
Title: Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.
Volume: 448
Issue: 2
Pages: 285-95
Publication
First Author: Inomata M
Year: 2021
Journal: Exp Cell Res
Title: Rictor-targeting exosomal microRNA-16 ameliorates lung fibrosis by inhibiting the mTORC2-SPARC axis.
Volume: 398
Issue: 2
Pages: 112416
Publication
First Author: Yang K
Year: 2011
Journal: Nat Immunol
Title: The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function.
Volume: 12
Issue: 9
Pages: 888-97
Publication    
First Author: Yang J
Year: 2016
Journal: Elife
Title: Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses.
Volume: 5
Publication
First Author: Chimin P
Year: 2017
Journal: J Lipid Res
Title: Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.
Volume: 58
Issue: 9
Pages: 1797-1807
Publication
First Author: Cho SH
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity.
Volume: 116
Issue: 18
Pages: 8975-8984
Publication
First Author: Alejandro EU
Year: 2017
Journal: Diabetes
Title: Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass.
Volume: 66
Issue: 8
Pages: 2150-2162
Publication
First Author: Liang Z
Year: 2018
Journal: Autophagy
Title: MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.
Volume: 14
Issue: 3
Pages: 505-517
Publication
First Author: Lee K
Year: 2012
Journal: J Exp Med
Title: Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.
Volume: 209
Issue: 4
Pages: 713-28
Publication
First Author: Lee K
Year: 2010
Journal: Immunity
Title: Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways.
Volume: 32
Issue: 6
Pages: 743-53
Publication
First Author: Albert V
Year: 2016
Journal: EMBO Mol Med
Title: mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.
Volume: 8
Issue: 3
Pages: 232-46
Publication  
First Author: Wu T
Year: 2016
Journal: Sci Rep
Title: mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors.
Volume: 6
Pages: 20250
Publication
First Author: Guo R
Year: 2023
Journal: Int Immunopharmacol
Title: Depletion of mTOR ameliorates CD(4)(+) T cell pyroptosis by promoting autophagy activity in septic mice.
Volume: 124
Issue: Pt B
Pages: 110964
Publication
First Author: Betz C
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology.
Volume: 110
Issue: 31
Pages: 12526-34
Publication
First Author: Tao R
Year: 2015
Journal: Diabetes
Title: Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.
Volume: 64
Issue: 4
Pages: 1211-23
Publication
First Author: Pollizzi KN
Year: 2015
Journal: J Clin Invest
Title: mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.
Volume: 125
Issue: 5
Pages: 2090-108
Publication
First Author: Newton RH
Year: 2018
Journal: Nat Immunol
Title: Maintenance of CD4 T cell fitness through regulation of Foxo1.
Volume: 19
Issue: 8
Pages: 838-848
Publication
First Author: Menk AV
Year: 2018
Journal: Cell Rep
Title: Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.
Volume: 22
Issue: 6
Pages: 1509-1521
Publication
First Author: Yang K
Year: 2013
Journal: Immunity
Title: T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming.
Volume: 39
Issue: 6
Pages: 1043-56
Publication
First Author: Delgoffe GM
Year: 2011
Journal: Nat Immunol
Title: The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.
Volume: 12
Issue: 4
Pages: 295-303
Publication
First Author: Monteiro LB
Year: 2022
Journal: Diabetes
Title: Leptin Signaling Suppression in Macrophages Improves Immunometabolic Outcomes in Obesity.
Volume: 71
Issue: 7
Pages: 1546-1561
Publication    
First Author: Kosillo P
Year: 2022
Journal: Elife
Title: Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2.
Volume: 11
Publication
First Author: Limon JJ
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.
Volume: 111
Issue: 47
Pages: E5076-85
Publication
First Author: Grahammer F
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.
Volume: 111
Issue: 27
Pages: E2817-26
Publication
First Author: Gödel M
Year: 2011
Journal: J Clin Invest
Title: Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.
Volume: 121
Issue: 6
Pages: 2197-209
Publication
First Author: Romanino K
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.
Volume: 108
Issue: 51
Pages: 20808-13
Publication
First Author: Werlen G
Year: 2022
Journal: Nat Commun
Title: Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis.
Volume: 13
Issue: 1
Pages: 7404
Publication
First Author: Wang H
Year: 2019
Journal: Virulence
Title: T-cell-specific mTOR deletion in mice ameliorated CD4+ T-cell survival in lethal sepsis induced by severe invasive candidiasis.
Volume: 10
Issue: 1
Pages: 892-901
Publication
First Author: Ou YH
Year: 2011
Journal: Mol Cell
Title: TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.
Volume: 41
Issue: 4
Pages: 458-70
Publication
First Author: Lamouille S
Year: 2012
Journal: J Cell Sci
Title: TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.
Volume: 125
Issue: Pt 5
Pages: 1259-73