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Search results 301 to 383 out of 383 for Rictor

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Type Details Score
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
22777355 | -
First Author: Agarwal NK
Year: 2013
Journal: Oncogene
Title: Rictor regulates cell migration by suppressing RhoGDI2.
Volume: 32
Issue: 20
Pages: 2521-6
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Publication
29955840 | J:266028
     
First Author: Gkountakos A
Year: 2018
Journal: Carcinogenesis
Title: Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex.
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HT Experiment
E-GEOD-67077 | Deletion of Rictor in brain and fat alters peripheral clock gene expression and increases blood pressure
Series Id: GSE67077
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
22285861 | J:181254
First Author: Guo Z
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells.
Volume: 418
Issue: 2
Pages: 426-32
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HT Experiment
E-GEOD-46515 | Expression data from mouse model using targeted deletion of hepatic RICTOR (Albumin-Cre Rictor LoxP/LoxP)
Series Id: GSE46515
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
31595162 | J:319589
First Author: Liu Z
Year: 2019
Journal: Int J Biol Sci
Title: Rictor ablation in BMSCs inhibits bone metastasis of TM40D cells by attenuating osteolytic destruction and CAF formation.
Volume: 15
Issue: 11
Pages: 2448-2460
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Allele
Rictor<em2Smoc> | MGI:7292055
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Rictor<em1Smoc> | MGI:7292054
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Rictor<Gt(RRR347)Byg> | MGI:3775093
Name: RPTOR independent companion of MTOR, complex 2; gene trap RRR347, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Protein Domain
IPR028267 | Pianissimo_N
Type: Domain
Description: The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].This domain is the N-terminal conserved section that may include several individual domains.
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Protein Domain
IPR029451 | RICTOR_M
Type: Domain
Description: This domain is found in the more conserved central section of Rictor (rapamycin-insensitive companion of mTOR) that may include several individual domains. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].
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Protein Domain
IPR029452 | RICTOR_V
Type: Domain
Description: This entry represent the conserved domain 5 of the Rictor (Rapamycin-insensitive companion of mTOR) protein. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].
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Protein Domain
IPR029453 | Rictor_IV
Type: Domain
Description: This entry represents the domain 4 of the Rictor (rapamycin-insensitive companion of mTOR) protein. It is found in the more conserved central section that may include several individual domainsThe mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].
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Publication
18089801 | -
First Author: Masri J
Year: 2007
Journal: Cancer Res
Title: mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor.
Volume: 67
Issue: 24
Pages: 11712-20
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GO Term
GO:0038203 | TORC2 signaling
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Strain
MGI:6476181 | C57BL/6J-Rictor<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Rictor/Rictor
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rictor/Rictor
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Publication
20418915 | -
First Author: Sparks CA
Year: 2010
Journal: Oncogene
Title: Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy.
Volume: 29
Issue: 26
Pages: 3733-44
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Protein Domain
IPR029259 | RICTOR_phospho
Type: PTM
Description: The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTORC1 and mTORC2, important for nutrient- and growth-factor signalling []. Rictor (rapamycin-insensitive companion of mTOR) is an essential component of the complex mTORC2 []. It appears to serve as a scaffolding protein important for maintaining mTORC2 integrity. Rictor interacts with 14-3-3 in a Thr1135-dependent manner []. Rictor can be inhibited by short-term rapamycin treatment, showing that Thr1135 is an mTORC1-regulated site [].This short region is the phoshorylation site of Rictor.
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Protein
Q8R5D5
Organism: Mus musculus/domesticus
Length: 796  
Fragment?: true
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Protein
Q6QI06
Organism: Mus musculus/domesticus
Length: 1708  
Fragment?: false
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Protein
Q0VAV3
Organism: Mus musculus/domesticus
Length: 1157  
Fragment?: false
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Publication
16079174 | -
First Author: Lee S
Year: 2005
Journal: Mol Biol Cell
Title: TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.
Volume: 16
Issue: 10
Pages: 4572-83
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Publication
15809876 | -
First Author: Ho HL
Year: 2005
Journal: Curr Genet
Title: Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex.
Volume: 47
Issue: 5
Pages: 273-88
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Publication
17261596 | -
First Author: Matsuo T
Year: 2007
Journal: Mol Cell Biol
Title: Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.
Volume: 27
Issue: 8
Pages: 3154-64
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Protein Domain
IPR028268 | Pianissimo_fam
Type: Family
Description: Protein pianissimo (PiaA) is a component of the target of rapamycin complex 2 (TORC2) in Dictyostelium []. This complex regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Homologues of PiaA are found in Saccharomyces cerevisiae (TSC11/AVO3) [], Schizosaccaromyces pombe (Ste20) [], and vertebrates, where it is also known as Rictor (rapamycin-insensitive companion of mTOR) [, ].Rictor, together with Sin1, is believed to function as an adaptor protein controlling the mTORC2 substrate binding and specificity. Rictor is known to have a role in cytoskeleton regulation and cell migration [, ]. It is likely that rictor regulates cell morphology and migration by playing a role as the indispensable component of mTORC2 and also by carrying mTORC2-independent functions.
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Protein
Q8CB99
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Protein
Q8C2V9
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: false
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Protein
Q9D2K3
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
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GO Term
GO:0031932 | TORC2 complex
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Genotype
Genotype
Symbol: Pten/Pten<+> Rictor/Rictor<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI:1924714 | Prr5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919696 | Prr5l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922675 | Tti1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2444554 | Mapkap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922997 | Sesn3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
33378666 | J:306498
First Author: Wrobel L
Year: 2020
Journal: Cell Rep
Title: mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR.
Volume: 33
Issue: 13
Pages: 108564
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Publication
24078700 | J:206233
First Author: Perkey E
Year: 2013
Journal: J Immunol
Title: Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function.
Volume: 191
Issue: 9
Pages: 4648-55
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Publication
33766857 | J:306989
 
First Author: Liu M
Year: 2021
Journal: Science
Title: WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity.
Volume: 371
Issue: 6536
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Publication
20876733 | J:164880
First Author: Lee DY
Year: 2010
Journal: Genes Dev
Title: Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner.
Volume: 24
Issue: 20
Pages: 2317-29
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Publication
27758884 | J:238010
First Author: Driscoll DR
Year: 2016
Journal: Cancer Res
Title: mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer.
Volume: 76
Issue: 23
Pages: 6911-6923
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Publication
32707034 | J:305278
First Author: Kim D
Year: 2020
Journal: Immunity
Title: Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism.
Volume: 53
Issue: 3
Pages: 581-596.e5
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Publication
25388284 | J:218209
First Author: Phung TL
Year: 2015
Journal: Cancer Res
Title: Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth.
Volume: 75
Issue: 1
Pages: 40-50
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Publication
24036451 | J:201730
First Author: Kamano Y
Year: 2013
Journal: FEBS Lett
Title: PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription.
Volume: 587
Issue: 20
Pages: 3303-8
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Publication
23792225 | J:204216
First Author: Sun SY
Year: 2013
Journal: Cancer Lett
Title: mTOR kinase inhibitors as potential cancer therapeutic drugs.
Volume: 340
Issue: 1
Pages: 1-8
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Publication
30733433 | J:270456
First Author: Körner A
Year: 2019
Journal: Nat Commun
Title: Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A.
Volume: 10
Issue: 1
Pages: 633
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Publication
35601917 | J:325003
First Author: Serna R
Year: 2022
Journal: iScience
Title: c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity.
Volume: 25
Issue: 6
Pages: 104325
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Publication
35869262 | J:327347
First Author: Wang Y
Year: 2022
Journal: Commun Biol
Title: mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling.
Volume: 5
Issue: 1
Pages: 726
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Publication
36220823 | J:329956
First Author: Wan S
Year: 2022
Journal: Cell Death Dis
Title: mTORC1 signaling pathway integrates estrogen and growth factor to coordinate vaginal epithelial cells proliferation and differentiation.
Volume: 13
Issue: 10
Pages: 862
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Publication
30858178 | J:277892
First Author: Dhar SK
Year: 2019
Journal: J Biol Chem
Title: UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation.
Volume: 294
Issue: 17
Pages: 6831-6842
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Publication
24847003 | J:214310
First Author: Ravichandran K
Year: 2014
Journal: Hum Mol Genet
Title: An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2.
Volume: 23
Issue: 18
Pages: 4919-31
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Publication
21965330 | J:178460
First Author: Wang RH
Year: 2011
Journal: J Clin Invest
Title: Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
Volume: 121
Issue: 11
Pages: 4477-90
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Publication
24008870 | J:218727
First Author: Völkers M
Year: 2013
Journal: Circulation
Title: Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.
Volume: 128
Issue: 19
Pages: 2132-44
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Publication
22045807 | J:323794
First Author: Brown J
Year: 2011
Journal: J Biol Chem
Title: Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1.
Volume: 286
Issue: 52
Pages: 44295-305
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Publication
37037900 | J:337651
First Author: Sane S
Year: 2023
Journal: Oncogene
Title: UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer.
Volume: 42
Issue: 21
Pages: 1763-1776
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Publication
36220588 | J:330385
First Author: Han X
Year: 2022
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Aerobic exercise ameliorates insulin resistance in C57BL/6 J mice via activating Sestrin3.
Volume: 1869
Issue: 1
Pages: 166568
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Publication
21339740 | J:180540
First Author: Kim EK
Year: 2011
Journal: Oncogene
Title: Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.
Volume: 30
Issue: 26
Pages: 2954-63
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Publication
23099444 | J:191225
First Author: Tripathy S
Year: 2013
Journal: J Lipid Res
Title: Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice.
Volume: 54
Issue: 1
Pages: 71-84
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Publication
24043828 | J:201130
First Author: Khanna N
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: XPLN is an endogenous inhibitor of mTORC2.
Volume: 110
Issue: 40
Pages: 15979-84
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Publication
24801387 | J:215265
First Author: Martin TD
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.
Volume: 306
Issue: 12
Pages: E1397-405
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Publication
25265063 | J:219303
First Author: He J
Year: 2015
Journal: Exp Cell Res
Title: Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: role of mTORC2/SGK1 pathway.
Volume: 331
Issue: 1
Pages: 164-75
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Publication
25918246 | J:224100
First Author: Koo J
Year: 2015
Journal: Mol Cell Biol
Title: mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation.
Volume: 35
Issue: 13
Pages: 2344-55
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Publication
28287249 | J:240168
First Author: Zheng B
Year: 2017
Journal: Int J Dev Biol
Title: mTORC1 and mTORC2 play different roles in regulating cardiomyocyte differentiation from embryonic stem cells.
Volume: 61
Issue: 1-2
Pages: 65-72
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Publication
24557881 | J:246545
First Author: Yano T
Year: 2014
Journal: Circ Res
Title: Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling.
Volume: 114
Issue: 8
Pages: 1268-80
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Publication
31138772 | J:278441
First Author: Manning JR
Year: 2019
Journal: Biochem J
Title: Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling.
Volume: 476
Issue: 12
Pages: 1713-1724
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Publication
31024074 | J:304910
First Author: Gui Y
Year: 2019
Journal: Cell Death Differ
Title: Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell death and acute kidney injury.
Volume: 26
Issue: 12
Pages: 2774-2789
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Publication
32917361 | J:304752
First Author: Tokumura K
Year: 2020
Journal: Biochem Biophys Res Commun
Title: mTOR regulates skeletogenesis through canonical and noncanonical pathways.
Volume: 533
Issue: 1
Pages: 30-35
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Publication
34261666 | J:343919
First Author: Breda CNS
Year: 2021
Journal: J Immunol
Title: Loss of mTORC2 Activity in Neutrophils Impairs Fusion of Granules and Affects Cellular Metabolism Favoring Increased Bacterial Burden in Sepsis.
Volume: 207
Issue: 2
Pages: 626-639
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Protein Coding Gene
MGI:1929514 | Mlst8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2651874 | Sesn2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
27099352 | J:235680
First Author: Abeyrathna P
Year: 2016
Journal: Am J Physiol Cell Physiol
Title: Calpain-2 activates Akt via TGF-β1-mTORC2 pathway in pulmonary artery smooth muscle cells.
Volume: 311
Issue: 1
Pages: C24-34
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Publication
30333721 | J:288896
 
First Author: Cuvelier E
Year: 2018
Journal: Front Mol Neurosci
Title: Overexpression of Wild-Type Human Alpha-Synuclein Causes Metabolism Abnormalities in Thy1-aSYN Transgenic Mice.
Volume: 11
Pages: 321
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Publication
25887856 | J:301754
 
First Author: Tandelilin AA
Year: 2015
Journal: BMC Endocr Disord
Title: AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle.
Volume: 15
Pages: 11
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Publication
24882582 | J:221270
First Author: Zhao T
Year: 2015
Journal: Oncogene
Title: Activation of mTOR pathway in myeloid-derived suppressor cells stimulates cancer cell proliferation and metastasis in lal(-/-) mice.
Volume: 34
Issue: 15
Pages: 1938-48
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Publication
28467426 | J:245549
First Author: Howell KR
Year: 2017
Journal: PLoS One
Title: PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia.
Volume: 12
Issue: 5
Pages: e0175993
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Protein Coding Gene
MGI:1914293 | Syap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1206581 | Pik3ca
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1928394 | Mtor
Type: protein_coding_gene
Organism: mouse, laboratory
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