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Search results 201 to 300 out of 6488 for App

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:6167596
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189798
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - App
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6167596
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189798
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - App
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6167596
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189798
Age: postnatal day 14
Specimen Label: Table S2 - P14 - App
Detected: true
Specimen Num: 6
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Publication
11959395 | J:102425
First Author: Flood DG
Year: 2002
Journal: Neurobiol Aging
Title: FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.
Volume: 23
Issue: 3
Pages: 335-48
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Publication
30902970 | J:276486
First Author: Dinamarca MC
Year: 2019
Journal: Nat Commun
Title: Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing.
Volume: 10
Issue: 1
Pages: 1331
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Publication
36635241 | J:332555
 
First Author: Huang M
Year: 2022
Journal: eNeuro
Title: Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with App (NL-G-F) Mice.
Volume: 9
Issue: 6
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Publication
26600047 | J:243866
First Author: Rabinovich-Toidman P
Year: 2015
Journal: PLoS One
Title: Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS.
Volume: 10
Issue: 11
Pages: e0143420
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Publication
10727079 | J:67623
First Author: Li L
Year: 1999
Journal: DNA Seq
Title: Analysis of mouse intron 7 DNA sequence of the APP gene: comparison with the human homologue.
Volume: 10
Issue: 4-5
Pages: 219-28
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Publication
33752701 | J:324399
First Author: Clayton K
Year: 2021
Journal: Mol Neurodegener
Title: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Volume: 16
Issue: 1
Pages: 18
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Publication
17470798 | J:121585
First Author: Ma H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.
Volume: 104
Issue: 19
Pages: 8167-72
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Publication
20637285 | J:171318
First Author: Alvira-Botero X
Year: 2010
Journal: Mol Cell Neurosci
Title: Megalin interacts with APP and the intracellular adapter protein FE65 in neurons.
Volume: 45
Issue: 3
Pages: 306-15
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Publication
22429478 | J:316812
 
First Author: Dumanis SB
Year: 2012
Journal: Mol Neurodegener
Title: FE65 as a link between VLDLR and APP to regulate their trafficking and processing.
Volume: 7
Pages: 9
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Publication
36781874 | J:341266
First Author: Park H
Year: 2023
Journal: Nat Commun
Title: Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice.
Volume: 14
Issue: 1
Pages: 802
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Publication
35544526 | J:325631
First Author: Cannavo C
Year: 2022
Journal: PLoS One
Title: Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome.
Volume: 17
Issue: 5
Pages: e0262558
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Publication
37536439 | J:339714
 
First Author: Hossain SR
Year: 2023
Journal: Exp Neurol
Title: Early tactile stimulation influences the development of Alzheimer's disease in gestationally stressed APP (NL-G-F) adult offspring (NL-G-F/NL-G-F) mice.
Volume: 368
Pages: 114498
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Publication
23133641 | J:195596
First Author: Yang SG
Year: 2012
Journal: PLoS One
Title: A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic mice.
Volume: 7
Issue: 11
Pages: e48540
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Publication
12927782 | J:85358
First Author: Rouvinski A
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes.
Volume: 308
Issue: 4
Pages: 750-8
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Publication
22057897 | J:301891
First Author: Stöhr O
Year: 2013
Journal: Age (Dordr)
Title: Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease.
Volume: 35
Issue: 1
Pages: 83-101
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Publication
24844149 | J:214313
 
First Author: Albers S
Year: 2014
Journal: Neurobiol Dis
Title: Nuclear 82-kDa choline acetyltransferase decreases amyloidogenic APP metabolism in neurons from APP/PS1 transgenic mice.
Volume: 69
Pages: 32-42
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Publication
28284905 | J:241006
First Author: Callahan DG
Year: 2017
Journal: Dev Biol
Title: Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex.
Volume: 424
Issue: 2
Pages: 138-146
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Publication
32610140 | J:301251
First Author: Park G
Year: 2020
Journal: Cell Rep
Title: Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease.
Volume: 31
Issue: 13
Pages: 107839
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Publication
32858147 | J:304392
 
First Author: Chiasseu M
Year: 2020
Journal: Neurobiol Dis
Title: Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in.
Volume: 145
Pages: 105059
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Publication
17112635 | J:130694
First Author: Van Broeck B
Year: 2008
Journal: Neurobiol Aging
Title: Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.
Volume: 29
Issue: 2
Pages: 241-52
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Publication
34187579 | J:311552
First Author: Emre C
Year: 2021
Journal: Acta Neuropathol Commun
Title: Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 116
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Publication
25481013 | J:217376
First Author: Wang Q
Year: 2014
Journal: Dis Model Mech
Title: Triptolide treatment reduces Alzheimer's disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD.
Volume: 7
Issue: 12
Pages: 1385-95
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Publication
26182420 | J:227681
First Author: Pasciuto E
Year: 2015
Journal: Neuron
Title: Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.
Volume: 87
Issue: 2
Pages: 382-98
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Publication
37364689 | J:338509
 
First Author: Mowry FE
Year: 2023
Journal: Neurobiol Dis
Title: Chronic nSMase inhibition suppresses neuronal exosome spreading and sex-specifically attenuates amyloid pathology in APP knock-in Alzheimer's disease mice.
Volume: 184
Pages: 106213
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Publication
28760161 | J:342281
First Author: Umeda T
Year: 2017
Journal: Acta Neuropathol Commun
Title: Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice.
Volume: 5
Issue: 1
Pages: 59
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Publication
19046405 | J:310291
First Author: Studzinski CM
Year: 2009
Journal: J Neurochem
Title: Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice.
Volume: 108
Issue: 4
Pages: 860-6
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Publication
23236292 | J:194853
First Author: Tu Z
Year: 2012
Journal: PLoS Genet
Title: Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets.
Volume: 8
Issue: 12
Pages: e1003107
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Publication
22829447 | J:208510
First Author: Son SM
Year: 2012
Journal: Diabetes
Title: Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathway.
Volume: 61
Issue: 12
Pages: 3126-38
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Publication
21305033 | J:169540
First Author: Yamada M
Year: 2011
Journal: PLoS One
Title: The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice.
Volume: 6
Issue: 1
Pages: e16567
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Publication
35054427 | J:334694
 
First Author: Minamisawa M
Year: 2021
Journal: Life (Basel)
Title: Amelioration of Alzheimer's Disease by Gut-Pancreas-Liver-Brain Interaction in an App Knock-In Mouse Model.
Volume: 12
Issue: 1
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Publication
36711209 | J:341265
 
First Author: Morrissey ZD
Year: 2022
Journal: Front Aging Neurosci
Title: Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer's disease.
Volume: 14
Pages: 1085989
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Publication
29348617 | J:257725
First Author: Miranda AM
Year: 2018
Journal: Nat Commun
Title: Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures.
Volume: 9
Issue: 1
Pages: 291
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Publication
38521860 | J:346304
     
First Author: Armstrong P
Year: 2024
Journal: Neuropsychopharmacology
Title: Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease.
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Publication
36362046 | J:334184
 
First Author: Maki T
Year: 2022
Journal: Int J Mol Sci
Title: APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer's Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression.
Volume: 23
Issue: 21
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Publication
31015456 | J:275576
First Author: Liu Y
Year: 2019
Journal: Nat Commun
Title: SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice.
Volume: 10
Issue: 1
Pages: 1886
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Publication
29661886 | J:265667
 
First Author: Richter MC
Year: 2018
Journal: EMBO J
Title: Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.
Volume: 37
Issue: 11
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Publication
28163681 | J:338180
 
First Author: Laßek M
Year: 2017
Journal: Front Synaptic Neurosci
Title: APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones.
Volume: 9
Pages: 1
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Publication
21088218 | J:167619
First Author: Ongali B
Year: 2010
Journal: Am J Pathol
Title: Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease.
Volume: 177
Issue: 6
Pages: 3071-80
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Publication
37819761 | J:348582
First Author: Wu Y
Year: 2023
Journal: Cell Rep
Title: Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis.
Volume: 42
Issue: 10
Pages: 113240
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Publication
26322584 | J:226790
First Author: Willem M
Year: 2015
Journal: Nature
Title: η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
Volume: 526
Issue: 7573
Pages: 443-7
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Publication
25098278 | J:315361
First Author: Ciccotosto GD
Year: 2014
Journal: Metallomics
Title: Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue.
Volume: 6
Issue: 10
Pages: 1894-904
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Publication
29510211 | J:262428
 
First Author: Izumi H
Year: 2018
Journal: Neuroscience
Title: The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.
Volume: 377
Pages: 87-97
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Publication
31407772 | J:287613
First Author: Shi A
Year: 2020
Journal: Cereb Cortex
Title: Preserved Calretinin Interneurons in an App Model of Alzheimer's Disease Disrupt Hippocampal Inhibition via Upregulated P2Y1 Purinoreceptors.
Volume: 30
Issue: 3
Pages: 1272-1290
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Publication
34008862 | J:325752
First Author: Steubler V
Year: 2021
Journal: EMBO J
Title: Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
Volume: 40
Issue: 12
Pages: e107471
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Publication
31235642 | J:278868
First Author: Yao W
Year: 2019
Journal: J Neurosci
Title: Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage.
Volume: 39
Issue: 35
Pages: 6992-7005
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Publication
26139848 | J:325924
First Author: Dislich B
Year: 2015
Journal: Mol Cell Proteomics
Title: Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.
Volume: 14
Issue: 10
Pages: 2550-63
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Publication
15583033 | J:94845
First Author: Abad-Rodriguez J
Year: 2004
Journal: J Cell Biol
Title: Neuronal membrane cholesterol loss enhances amyloid peptide generation.
Volume: 167
Issue: 5
Pages: 953-60
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Publication
32444385 | J:297385
First Author: Rolland M
Year: 2020
Journal: J Neurosci
Title: Effect of Aβ Oligomers on Neuronal APP Triggers a Vicious Cycle Leading to the Propagation of Synaptic Plasticity Alterations to Healthy Neurons.
Volume: 40
Issue: 27
Pages: 5161-5176
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Publication
17920016 | J:126954
First Author: Liu Q
Year: 2007
Journal: Neuron
Title: Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.
Volume: 56
Issue: 1
Pages: 66-78
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Publication
22223639 | J:182773
First Author: Sadleir KR
Year: 2012
Journal: J Biol Chem
Title: Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease.
Volume: 287
Issue: 10
Pages: 7224-35
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Publication
34958017 | J:334681
First Author: Abdelhamid M
Year: 2022
Journal: J Alzheimers Dis
Title: Probiotic Bifidobacterium breve Prevents Memory Impairment Through the Reduction of Both Amyloid-β Production and Microglia Activation in APP Knock-In Mouse.
Volume: 85
Issue: 4
Pages: 1555-1571
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Publication
19074428 | J:232987
First Author: Vetrivel KS
Year: 2009
Journal: J Biol Chem
Title: Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.
Volume: 284
Issue: 6
Pages: 3793-803
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Publication
20833873 | J:167784
First Author: Pavlov PF
Year: 2011
Journal: FASEB J
Title: Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein.
Volume: 25
Issue: 1
Pages: 78-88
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Publication
20704561 | J:277904
First Author: Davis W Jr
Year: 2010
Journal: Curr Alzheimer Res
Title: The ATP-binding cassette transporter-2 (ABCA2) increases endogenous amyloid precursor protein expression and Aβ fragment generation.
Volume: 7
Issue: 7
Pages: 566-77
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Publication
21248127 | J:168561
First Author: Beckmann N
Year: 2011
Journal: J Neurosci
Title: Noninvasive magnetic resonance imaging detection of cerebral amyloid angiopathy-related microvascular alterations using superparamagnetic iron oxide particles in APP transgenic mouse models of Alzheimer's disease: application to passive Abeta immunotherapy.
Volume: 31
Issue: 3
Pages: 1023-31
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Publication
27517085 | J:237784
 
First Author: Cheng N
Year: 2016
Journal: eNeuro
Title: APP Overexpression Causes Aβ-Independent Neuronal Death through Intrinsic Apoptosis Pathway.
Volume: 3
Issue: 4
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Publication
29632166 | J:261965
First Author: Stern AL
Year: 2018
Journal: J Neurosci
Title: BACE1 Mediates HIV-Associated and Excitotoxic Neuronal Damage Through an APP-Dependent Mechanism.
Volume: 38
Issue: 18
Pages: 4288-4300
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Publication
25592972 | J:229208
First Author: Kizuka Y
Year: 2015
Journal: EMBO Mol Med
Title: An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
Volume: 7
Issue: 2
Pages: 175-89
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Author
Velosa APP
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App H
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Publication
33183323 | J:324394
First Author: Saifullah MAB
Year: 2020
Journal: Mol Brain
Title: Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease.
Volume: 13
Issue: 1
Pages: 147
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Publication
31164199 | J:291162
First Author: Izuo N
Year: 2019
Journal: Biochem Biophys Res Commun
Title: An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease.
Volume: 515
Issue: 3
Pages: 462-467
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Publication
16325786 | J:103913
First Author: Mahadomrongkul V
Year: 2005
Journal: Brain Res
Title: Stability of the distribution of spines containing drebrin A in the sensory cortex layer I of mice expressing mutated APP and PS1 genes.
Volume: 1064
Issue: 1-2
Pages: 66-74
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Publication
8510506 | J:4115
First Author: Solà C
Year: 1993
Journal: Brain Res Mol Brain Res
Title: Regional distribution of the alternatively spliced isoforms of beta APP RNA transcript in the brain of normal, heterozygous and homozygous weaver mutant mice as revealed by in situ hybridization histochemistry.
Volume: 17
Issue: 3-4
Pages: 340-6
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Publication
15123597 | J:91545
First Author: Rossner S
Year: 2004
Journal: J Biol Chem
Title: Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.
Volume: 279
Issue: 27
Pages: 27841-4
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Publication
16407538 | J:104263
First Author: Spoelgen R
Year: 2006
Journal: J Neurosci
Title: Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
Volume: 26
Issue: 2
Pages: 418-28
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Publication
28502705 | J:251833
First Author: Shi Z
Year: 2017
Journal: Biochim Biophys Acta
Title: BAG-1M co-activates BACE1 transcription through NF-κB and accelerates Aβ production and memory deficit in Alzheimer's disease mouse model.
Volume: 1863
Issue: 9
Pages: 2398-2407
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Publication
17573534 | J:122497
First Author: Parkin ET
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.
Volume: 104
Issue: 26
Pages: 11062-7
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Publication
11740561 | J:73257
First Author: Kamal A
Year: 2001
Journal: Nature
Title: Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP.
Volume: 414
Issue: 6864
Pages: 643-8
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Publication
35210996 | J:324409
 
First Author: Kundu P
Year: 2022
Journal: Front Behav Neurosci
Title: Fecal Implants From App NL-G-F and App NL-G-F/E4 Donor Mice Sufficient to Induce Behavioral Phenotypes in Germ-Free Mice.
Volume: 16
Pages: 791128
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Publication
11741394 | J:73622
First Author: Kulnane LS
Year: 2001
Journal: Neurobiol Dis
Title: Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice.
Volume: 8
Issue: 6
Pages: 982-92
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Publication
9285791 | J:42613
First Author: Lamb BT
Year: 1997
Journal: Hum Mol Genet
Title: Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.
Volume: 6
Issue: 9
Pages: 1535-41
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Publication
14506131 | J:86629
First Author: Lehman EJ
Year: 2003
Journal: Hum Mol Genet
Title: Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse.
Volume: 12
Issue: 22
Pages: 2949-56
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Publication
35663567 | J:328522
 
First Author: Jiang R
Year: 2022
Journal: Front Aging Neurosci
Title: Autophagy Impairment in App Knock-in Alzheimer's Model Mice.
Volume: 14
Pages: 878303
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Publication
21795680 | J:176738
First Author: Griffiths HH
Year: 2011
Journal: J Biol Chem
Title: Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.
Volume: 286
Issue: 38
Pages: 33489-500
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Publication
31442405 | J:290398
First Author: Suh J
Year: 2019
Journal: Cell
Title: Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.
Volume: 178
Issue: 5
Pages: 1159-1175.e17
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Publication
19357271 | J:147429
First Author: Hoey SE
Year: 2009
Journal: J Neurosci
Title: Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.
Volume: 29
Issue: 14
Pages: 4442-60
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Publication
25957769 | J:221641
First Author: Kizuka Y
Year: 2015
Journal: FEBS Lett
Title: Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation.
Volume: 589
Issue: 13
Pages: 1418-22
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Publication
24005676 | J:207246
First Author: Deng M
Year: 2013
Journal: J Biol Chem
Title: Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.
Volume: 288
Issue: 42
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Allele
Tg(THY1-APP)2Somm | MGI:2447145
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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