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Search results 1001 to 1092 out of 1092 for Tnnt2

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Type Details Score
Genotype
Genotype
Symbol: Tg(Myh6-Tnnt2*)1Feah/? Tnnt2/Tnnt2<+>
Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
28839205 | J:256565
First Author: Ishizu T
Year: 2017
Journal: Sci Rep
Title: Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes.
Volume: 7
Issue: 1
Pages: 9363
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Publication
36610028 | J:344822
First Author: Morita T
Year: 2023
Journal: FEBS Open Bio
Title: Actin-related protein 5 suppresses the cooperative activation of cardiac gene transcription by myocardin and MEF2.
Volume: 13
Issue: 2
Pages: 363-379
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Protein
A0A087WQP1
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Publication
9482583 | -
First Author: Gerull B
Year: 1998
Journal: Hum Mutat
Title: A rapid protocol for cardiac troponin T gene mutation detection in familial hypertrophic cardiomyopathy.
Volume: 11
Issue: 2
Pages: 179-82
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Publication
10952871 | -
First Author: Johnston JJ
Year: 2000
Journal: Am J Hum Genet
Title: A novel nemaline myopathy in the Amish caused by a mutation in troponin T1.
Volume: 67
Issue: 4
Pages: 814-21
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Publication
11034944 | -
First Author: Ho CY
Year: 2000
Journal: Circulation
Title: Homozygous mutation in cardiac troponin T: implications for hypertrophic cardiomyopathy.
Volume: 102
Issue: 16
Pages: 1950-5
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Protein Domain
IPR027707 | TNNT
Type: Family
Description: The troponin (Tn) complex regulates calcium-induced muscle contraction. Tn contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT), which is required for Ca(2+)-mediated activation of actomyosin ATPase activity [, ]. Three different troponin T genes that encode tissue-specific isoforms of subunit T have been found in mammals and birds, encoding cardiac (TNNT2), slow (TNNT1), and fast (TNNT3) skeletal muscle TnT isoforms [, , , ].Mutations of the TNNT1gene cause nemaline myopathy [], while mutations of the TNNT2 gene cause familial hypertrophic cardiomyopathy [, ], and mutations of the TNNT3 gene cause Arthrogryposis, distal, 2B2 (DA2B2) [].
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Publication
23921644 | J:213466
First Author: Lu D
Year: 2013
Journal: Transgenic Res
Title: WIF1 causes dysfunction of heart in transgenic mice.
Volume: 22
Issue: 6
Pages: 1179-89
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Publication
29155983 | J:284203
First Author: Lu D
Year: 2018
Journal: Cardiovasc Res
Title: Meox1 accelerates myocardial hypertrophic decompensation through Gata4.
Volume: 114
Issue: 2
Pages: 300-311
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Publication
14993121 | J:162684
First Author: Tsybouleva N
Year: 2004
Journal: Circulation
Title: Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy.
Volume: 109
Issue: 10
Pages: 1284-91
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Publication
32210830 | J:307837
 
First Author: Chowdhury SAK
Year: 2020
Journal: Front Physiol
Title: Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response.
Volume: 11
Pages: 107
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Publication
23532597 | J:213305
First Author: Huke S
Year: 2013
Journal: Circ Res
Title: Focal energy deprivation underlies arrhythmia susceptibility in mice with calcium-sensitized myofilaments.
Volume: 112
Issue: 10
Pages: 1334-44
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Publication
12600890 | J:135877
First Author: Knollmann BC
Year: 2003
Journal: Circ Res
Title: Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling.
Volume: 92
Issue: 4
Pages: 428-36
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Publication
22647877 | J:212654
First Author: Schober T
Year: 2012
Journal: Circ Res
Title: Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia.
Volume: 111
Issue: 2
Pages: 170-9
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Publication
16214409 | J:308074
First Author: Westermann D
Year: 2006
Journal: Eur J Heart Fail
Title: Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy.
Volume: 8
Issue: 2
Pages: 115-21
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Protein
Q3TQ90
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
E9PZB4
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
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Protein
A0A087WRX3
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
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Protein
E9PVN9
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Publication
26023924 | J:233556
First Author: Prendiville TW
Year: 2015
Journal: PLoS One
Title: Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase.
Volume: 10
Issue: 5
Pages: e0128105
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Publication
24584570 | J:210662
First Author: Beraldi R
Year: 2014
Journal: Hum Mol Genet
Title: Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy.
Volume: 23
Issue: 14
Pages: 3779-91
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Publication
11685458 | J:72436
First Author: Morroll S
Year: 2001
Journal: Immunogenetics
Title: The genes encoding E-selectin (SELE) and lymphotactin (SCYC1) lie on separate chicken chromosomes although they are closely linked in human and mouse.
Volume: 53
Issue: 6
Pages: 477-82
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Publication
20083571 | J:175886
First Author: Luedde M
Year: 2010
Journal: Cardiovasc Res
Title: Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation.
Volume: 86
Issue: 3
Pages: 452-60
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Publication
29903739 | J:292060
First Author: Boogerd CJ
Year: 2018
Journal: Circ Res
Title: Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development.
Volume: 123
Issue: 4
Pages: 428-442
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Publication
32112822 | J:292407
 
First Author: Benitez-Amaro A
Year: 2020
Journal: Metabolism
Title: Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity.
Volume: 106
Pages: 154191
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Publication
9788962 | J:117554
First Author: Oberst L
Year: 1998
Journal: J Clin Invest
Title: Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice.
Volume: 102
Issue: 8
Pages: 1498-505
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Publication
30586744 | J:289047
First Author: Lehman SJ
Year: 2019
Journal: Circulation
Title: Chronic Calmodulin-Kinase II Activation Drives Disease Progression in Mutation-Specific Hypertrophic Cardiomyopathy.
Volume: 139
Issue: 12
Pages: 1517-1529
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Publication
11600691 | J:133824
First Author: Montgomery DE
Year: 2001
Journal: J Physiol
Title: Cardiac troponin T mutations: correlation between the type of mutation and the nature of myofilament dysfunction in transgenic mice.
Volume: 536
Issue: Pt 2
Pages: 583-92
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Publication
12414446 | J:82055
First Author: Lucas DT
Year: 2003
Journal: Am J Physiol Heart Circ Physiol
Title: Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy.
Volume: 284
Issue: 2
Pages: H575-83
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Publication
29563334 | J:307897
 
First Author: Vakrou S
Year: 2018
Journal: JCI Insight
Title: Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models.
Volume: 3
Issue: 6
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Publication
34162896 | J:323703
First Author: Vakrou S
Year: 2021
Journal: Sci Rep
Title: Differences in molecular phenotype in mouse and human hypertrophic cardiomyopathy.
Volume: 11
Issue: 1
Pages: 13163
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Publication
31921893 | J:307875
 
First Author: Liu Y
Year: 2019
Journal: Front Cardiovasc Med
Title: Differences in microRNA-29 and Pro-fibrotic Gene Expression in Mouse and Human Hypertrophic Cardiomyopathy.
Volume: 6
Pages: 170
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Genotype
Genotype
Symbol: Znhit1/Znhit1 Tg(Tnnt2-rtTA,tetO-cre)1Wtp/?
Background: involves: C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tnnt2/Tnnt2<+>
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Protein
P50752
Organism: Mus musculus/domesticus
Length: 301  
Fragment?: false
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Publication
10095098 | J:53882
First Author: Huang QQ
Year: 1999
Journal: Gene
Title: Genomic sequence and structural organization of mouse slow skeletal muscle troponin T gene.
Volume: 229
Issue: 1-2
Pages: 1-10
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Protein
O88346
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
Q3TH80
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
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Protein
J3QQ13
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Protein
B7ZNV4
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Protein
Q9CTJ8
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
J3QPC8
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
E9Q688
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
K3W4R7
Organism: Mus musculus/domesticus
Length: 301  
Fragment?: false
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Protein
E9QA86
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
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Protein
A2A6J2
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
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Protein
E9Q0G9
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
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Protein
K3W4R6
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
Q6P3Z7
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Protein
Q3TVB8
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Publication
20965144 | -
First Author: Wei B
Year: 2011
Journal: Arch Biochem Biophys
Title: Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function.
Volume: 505
Issue: 2
Pages: 144-54
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Publication
16839517 | -
First Author: Gallon CE
Year: 2006
Journal: Arch Biochem Biophys
Title: Differences in myofilament calcium sensitivity in rat psoas fibers reconstituted with troponin T isoforms containing the alpha- and beta-exons.
Volume: 456
Issue: 2
Pages: 127-34
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Publication
2993302 | -
First Author: Cooper TA
Year: 1985
Journal: J Biol Chem
Title: A single cardiac troponin T gene generates embryonic and adult isoforms via developmentally regulated alternate splicing.
Volume: 260
Issue: 20
Pages: 11140-8
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Publication
1433301 | -
First Author: Jin JP
Year: 1992
Journal: J Mol Biol
Title: Complete nucleotide sequence and structural organization of rat cardiac troponin T gene. A single gene generates embryonic and adult isoforms via developmentally regulated alternative splicing.
Volume: 227
Issue: 4
Pages: 1269-76
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Publication
9689598 | -
First Author: Farza H
Year: 1998
Journal: J Mol Cell Cardiol
Title: Genomic organisation, alternative splicing and polymorphisms of the human cardiac troponin T gene.
Volume: 30
Issue: 6
Pages: 1247-53
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Publication
12865991 | -
First Author: Sung SS
Year: 2003
Journal: Am J Hum Genet
Title: Mutations in TNNT3 cause multiple congenital contractures: a second locus for distal arthrogryposis type 2B.
Volume: 73
Issue: 1
Pages: 212-4
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Protein
Q9QZ47
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: false
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Protein
Z4YKF8
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Protein
A2A6I0
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Protein
A0A0R4J1A8
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: false
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Protein
A2A6H6
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
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Protein
Z4YJU0
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: false
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Protein
F6RL36
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: true
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Protein
A2A6I3
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Protein
Z4YKG8
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
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Protein
A0A0R4J1B0
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: false
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Protein
Z4YKE7
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
Q8R563
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: true
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Protein
Z4YKH8
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Protein
Z4YKD9
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Protein
A2A6I8
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
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Protein
A2A6I5
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
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Protein
Z4YKG3
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
Z4YNB2
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: false
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Protein
A2A6J0
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: false
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Protein
J3QP61
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: false
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Protein
A2A6J1
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Protein
A0A0R4J1B1
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Publication
26628621 | J:239436
First Author: Zhang W
Year: 2016
Journal: Circulation
Title: Critical Roles of STAT3 in β-Adrenergic Functions in the Heart.
Volume: 133
Issue: 1
Pages: 48-61
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Publication
26952936 | J:251477
First Author: Han P
Year: 2016
Journal: Biochim Biophys Acta
Title: Epigenetic response to environmental stress: Assembly of BRG1-G9a/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts.
Volume: 1863
Issue: 7 Pt B
Pages: 1772-81
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Publication
25119045 | J:213053
First Author: Han P
Year: 2014
Journal: Nature
Title: A long noncoding RNA protects the heart from pathological hypertrophy.
Volume: 514
Issue: 7520
Pages: 102-106
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Publication
29215012 | J:255076
First Author: Zhang D
Year: 2017
Journal: Nat Commun
Title: REST regulates the cell cycle for cardiac development and regeneration.
Volume: 8
Issue: 1
Pages: 1979
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Publication
26893347 | J:240161
First Author: Yu W
Year: 2016
Journal: Development
Title: GATA4 regulates Fgf16 to promote heart repair after injury.
Volume: 143
Issue: 6
Pages: 936-49
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Publication
25071185 | J:213701
First Author: Hubbi ME
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression.
Volume: 111
Issue: 32
Pages: E3325-34
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Publication
19233194 | J:149164
First Author: Luckey SW
Year: 2009
Journal: J Mol Cell Cardiol
Title: The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy.
Volume: 46
Issue: 5
Pages: 739-47
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Genotype
Genotype
Symbol: Zfpm2/Zfpm2 Tg(Tnnt2-rtTA,tetO-cre)1Wtp/?
Background: involves: 129S1/Sv * 129S7/SvEvBrd
Zygosity: cn
Has Mutant Allele: true
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Publication
25848038 | J:220962
First Author: Hathaway CK
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade.
Volume: 112
Issue: 16
Pages: 5141-6
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Publication
21505261 | J:253158
First Author: Zhou B
Year: 2011
Journal: J Clin Invest
Title: Adult mouse epicardium modulates myocardial injury by secreting paracrine factors.
Volume: 121
Issue: 5
Pages: 1894-904
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Publication
20596014 | J:162637
First Author: Hang CT
Year: 2010
Journal: Nature
Title: Chromatin regulation by Brg1 underlies heart muscle development and disease.
Volume: 466
Issue: 7302
Pages: 62-7
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Publication
34323119 | J:313822
First Author: Pal S
Year: 2021
Journal: J Am Heart Assoc
Title: Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling.
Volume: 10
Issue: 15
Pages: e021768
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Publication
19411759 | J:150452
First Author: Zhou B
Year: 2009
Journal: J Clin Invest
Title: Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.
Volume: 119
Issue: 6
Pages: 1462-76
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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