This entry represents a group of PITH domain-containing proteins, including PITHD1 from animals. PITHD1 acts as an activator of an internal ribosome entry site (IRES) element in the RUNX1 gene and enhances RUNX1 expression that subsequently promoted megakaryocyte differentiation [].
This group represents runt-related transcription factors RUNX. The RUNX family of transcription factors plays important roles in hematopoiesis, neurogenesis, bone development, and segmentation in vertebrate embryos. RUNX1 and its Xenopus and Drosophila homologues appear to determine hematopoietic cell fate during development [].
MEF-2 (also known as MyEF-2) is a sequence-specific single-stranded DNA (ssDNA) binding protein that binds specifically to ssDNA derived from the proximal (MB1) element of the myelin basic protein (MBP) promoter and represses transcription of the MBP gene [, ]. MEF-2 contains two RNA recognition motifs (RRMs). MEF-2 is also a binding partner of RUNX1 during erythropoiesis, which is bound in undifferentiated cells and lost upon differentiation [].
