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Search results 201 to 229 out of 229 for Shb

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0.017s

Type

Details

Score

Publication

- | J:91388

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations

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Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

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Publication

- | J:155721

First Author:	Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year:	2010
Journal:	Database Download
Title:	Consensus CDS project

•

Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

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Publication

- | J:63103

First Author:	Mouse Genome Database and National Center for Biotechnology Information
Year:	2000
Journal:	Database Release
Title:	Entrez Gene Load

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Publication

- | J:262123

First Author:	Allen Institute for Brain Science
Year:	2004
Journal:	Allen Institute
Title:	Allen Brain Atlas: mouse riboprobes

•

Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

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Publication

- | J:85324

First Author:	Mouse Genome Informatics Group
Year:	2003
Journal:	Database Procedure
Title:	Automatic Encodes (AutoE) Reference

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Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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UniProt Feature

Begin:	1173
Description:	Interaction with SHB
Type:	site
End:	1173

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UniProt Feature

Begin:	766
Description:	Mediates interaction with PLCG1 and SHB
Type:	site
End:	766

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Publication

10404514 | J:75844

First Author:	Welsh M
Year:	1999
Journal:	Mol Med
Title:	Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells.
Volume:	5
Issue:	3
Pages:	169-80

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Publication

8777141 | -

First Author:	Lavergne C
Year:	1996
Journal:	Cell Signal
Title:	Control of SHB gene expression by protein phosphorylation.
Volume:	8
Issue:	1
Pages:	55-8

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Publication

10837138 | -

First Author:	Hooshmand-Rad R
Year:	2000
Journal:	Exp Cell Res
Title:	Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization.
Volume:	257
Issue:	2
Pages:	245-54

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Publication

15026417 | -

First Author:	Holmqvist K
Year:	2004
Journal:	J Biol Chem
Title:	The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.
Volume:	279
Issue:	21
Pages:	22267-75

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Publication

12181353 | -

First Author:	Cross MJ
Year:	2002
Journal:	Mol Biol Cell
Title:	The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.
Volume:	13
Issue:	8
Pages:	2881-93

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Publication

7537362 | -

First Author:	Karlsson T
Year:	1995
Journal:	Oncogene
Title:	Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.
Volume:	10
Issue:	8
Pages:	1475-83

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Publication

17416457 | J:122342

First Author:	Akerblom B
Year:	2007
Journal:	Mol Cell Endocrinol
Title:	A role of FRK in regulation of embryonal pancreatic beta cell formation.
Volume:	270
Issue:	1-2
Pages:	73-8

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Publication

7664264 | -

First Author:	Craven RJ
Year:	1995
Journal:	Cancer Res
Title:	The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.
Volume:	55
Issue:	18
Pages:	3969-72

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Publication

19652529 | -

First Author:	Brauer PM
Year:	2009
Journal:	Cell Cycle
Title:	RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.
Volume:	8
Issue:	17
Pages:	2728-32

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Publication

7696183 | -

First Author:	Cance WG
Year:	1994
Journal:	Cell Growth Differ
Title:	Rak, a novel nuclear tyrosine kinase expressed in epithelial cells.
Volume:	5
Issue:	12
Pages:	1347-55

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Publication

12776987 | -

First Author:	Annerén C
Year:	2003
Journal:	Curr Mol Med
Title:	The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation.
Volume:	3
Issue:	4
Pages:	313-24

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Protein Domain

IPR035805 | SH2_Frk

Type:

Domain

Description:

Frk (RAK) is a member of the Src non-receptor type tyrosine kinase family of proteins. The Frk subfamily is composed of Frk/Rak and Iyk/Bsk/Gst. It is expressed primarily epithelial cells. Frk is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth []. Unlike the other Src members it lacks a glycine at position 2 of SH4 which is important for addition of a myristic acid moiety that is involved in targeting Src PTKs to cellular membranes []. FRK and SHB exert similar effects when overexpressed in rat phaeochromocytoma (PC12) and beta-cells, where both induce PC12 cell differentiation and beta-cell proliferation. Under conditions that cause beta-cell degeneration these proteins augment beta-cell apoptosis. The FRK-SHB responses involve FAK and insulin receptor substrates (IRS) -1 and -2 []. Frk has been demonstrated to interact with retinoblastoma protein []. Frk regulates PTEN protein stability by phosphorylating PTEN, which in turn prevents PTEN degradation []. Frk also plays a role in regulation of embryonal pancreatic beta cell formation [].The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs [].

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Publication

31847469 | J:295882

First Author:	Pietilä I
Year:	2019
Journal:	Cells
Title:	Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB.
Volume:	8
Issue:	12

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Publication

12520087 | J:93554

First Author:	Annerén C
Year:	2002
Journal:	Mol Med
Title:	GTK tyrosine kinase-induced alteration of IRS-protein signalling in insulin producing cells.
Volume:	8
Issue:	11
Pages:	705-13

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Publication

36394315 | J:332912

First Author:	Chen Y
Year:	2022
Journal:	J Virol
Title:	Small Hepatitis B Virus Surface Antigen Promotes Hepatic Gluconeogenesis via Enhancing Glucagon/cAMP/Protein Kinase A/CREB Signaling.
Volume:	96
Issue:	23
Pages:	e0102022

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Publication

28347651 | -

First Author:	Kükenshöner T
Year:	2017
Journal:	J Mol Biol
Title:	Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
Volume:	429
Issue:	9
Pages:	1364-1380

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Protein

Q922K9

Organism:	Mus musculus/domesticus
Length:	512
Fragment?:	false

•

Protein

Q8BPC1

Organism:	Mus musculus/domesticus
Length:	393
Fragment?:	false

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