Type |
Details |
Score |
Publication |
First Author: |
Geiszt M |
Year: |
2003 |
Journal: |
FASEB J |
Title: |
Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. |
Volume: |
17 |
Issue: |
11 |
Pages: |
1502-4 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents dual oxidase 2 (DUOX2). DUOX1 and DUOX2 are isoenzymes that belong to the family of NADPH oxidases (Nox) []. They function as calcium-dependent NADPH oxidases producing hydrogen peroxide (H2O2) which is required for thyroid hormone biosynthesis []and the activity of lactoperoxidase (LPO) []. Duox2 is activated by activation of protein kinase C (PKC) and can be suppressed by thyroglobulin (Tg) [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Ha EM |
Year: |
2005 |
Journal: |
Science |
Title: |
A direct role for dual oxidase in Drosophila gut immunity. |
Volume: |
310 |
Issue: |
5749 |
Pages: |
847-50 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
232
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng G |
Year: |
2008 |
Journal: |
Free Radic Biol Med |
Title: |
Identification and characterization of VPO1, a new animal heme-containing peroxidase. |
Volume: |
45 |
Issue: |
12 |
Pages: |
1682-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Donkó Á |
Year: |
2014 |
Journal: |
Free Radic Biol Med |
Title: |
Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2. |
Volume: |
73 |
|
Pages: |
190-200 |
|
•
•
•
•
•
|
Publication |
First Author: |
Du H |
Year: |
2021 |
Journal: |
Int Immunopharmacol |
Title: |
Deficiency of voltage-gated proton channel Hv1 aggravates ovalbumin-induced allergic lung asthma in mice. |
Volume: |
96 |
|
Pages: |
107640 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng YY |
Year: |
2019 |
Journal: |
J Immunol |
Title: |
Essential Role of NADPH Oxidase-Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation. |
Volume: |
202 |
Issue: |
9 |
Pages: |
2546-2557 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cagle L |
Year: |
2021 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Role of Dual Oxidases in Ventilator-induced Lung Injury. |
Volume: |
64 |
Issue: |
2 |
Pages: |
208-215 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cha JJ |
Year: |
2017 |
Journal: |
Lab Invest |
Title: |
APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. |
Volume: |
97 |
Issue: |
4 |
Pages: |
419-431 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cagle LA |
Year: |
2022 |
Journal: |
Front Physiol |
Title: |
Early mechanisms of neutrophil activation and transmigration in acute lung injury. |
Volume: |
13 |
|
Pages: |
1059686 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1545
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1058
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1551
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1545
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1517
|
Fragment?: |
false |
|
•
•
•
•
•
|