Tenascin-R (TNR) is an extracellular matrix glycoprotein that is expressed primarily in the central nervous system. It regulates neurogenesis and affects cell migration, adhesion and differentiation [, ].Tenascins are extracellular matrix glycoproteins that act both as integrin ligands and as modifiers of fibronectin-integrin interactions toregulate cell adhesion, migration, proliferation and differentiation. Tenascins are usually composed of repeated epidermal growth factor (EGF)-like domains, fibronectin-type III (FNIII) domains and a C-terminal fibrinogen related domain (FReD) [].