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Search results 2201 to 2260 out of 2260 for Fn1

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Type Details Score
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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GXD Expression
GXD Expression
 
Probe: MGI:6304342
Assay Type: Immunohistochemistry
Annotation Date: 2019-05-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3549820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6304429
Age: embryonic day 12.5
Note: Coexpressed with Fn1 in endothelial cells.
Specimen Label: 2a
Detected: true
Specimen Num: 1
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Allele
Notch1<tm2Rko> | MGI:3044585
Name: notch 1; targeted mutation 2, Raphael Kopan
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Fn1<em2Smoc> | MGI:7289719
Name: fibronectin 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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GXD Expression
GXD Expression
 
Probe: MGI:6304342
Assay Type: Immunohistochemistry
Annotation Date: 2019-05-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914327
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6304429
Age: postnatal day 2
Note: Expression spred to the haematopoietic compartments. Co-expressed with Fn1 in sinus endothelial cells.
Specimen Label: 6b
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:6304342
Assay Type: Immunohistochemistry
Annotation Date: 2019-05-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1720326
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6304429
Age: embryonic day 18.5
Note: Decreased expression. Few areas of Vcam1 and Fn1 co-expressed were seen.
Specimen Label: 2b
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6304342
Assay Type: Immunohistochemistry
Annotation Date: 2019-05-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3549826
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6304429
Age: embryonic day 18.5
Note: Decreased expression. Few areas of Vcam1 and Fn1 co-expressed were seen. Expressed in endothelial cells.
Specimen Label: 2b
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6304342
Assay Type: Immunohistochemistry
Annotation Date: 2019-05-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3753928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6304429
Age: postnatal day 4
Note: Coexpression with Fn1 increased markedly on the surface layers of trabecular bone.
Specimen Label: 6c
Detected: true
Specimen Num: 7
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Strain
MGI:6475294 | C57BL/6-Fn1<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Fn1<em1Smoc> | MGI:7289718
Name: fibronectin 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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DO Term
DOID:0112297 | spondylometaphyseal dysplasia corner fracture type
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Strain
MGI:6770762 | C57BL/6J-Fn1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Tg(Fn1-cre)41Stl | MGI:6113839
Name: transgene insertion 41, Susumu Tonegawa
Allele Type: Transgenic
Attribute String: Recombinase
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Protein
A0A087WQW8
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: true
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Publication
1900516 | -
First Author: Bennett WF
Year: 1991
Journal: J Biol Chem
Title: High resolution analysis of functional determinants on human tissue-type plasminogen activator.
Volume: 266
Issue: 8
Pages: 5191-201
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Publication
1602484 | -
First Author: Downing AK
Year: 1992
Journal: J Mol Biol
Title: Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance.
Volume: 225
Issue: 3
Pages: 821-33
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Publication
2112232 | -
First Author: Baron M
Year: 1990
Journal: Nature
Title: Structure of the fibronectin type 1 module.
Volume: 345
Issue: 6276
Pages: 642-6
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Publication
7582899 | -
First Author: Smith BO
Year: 1995
Journal: Structure
Title: The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator.
Volume: 3
Issue: 8
Pages: 823-33
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Protein Domain
IPR000083 | Fibronectin_type1
Type: Domain
Description: Fibronectin type I repeats are one of the three repeats found in the fibronectin protein.Fibronectin is a plasma protein that binds cell surfaces and various compoundsincluding collagen, fibrin, heparin, DNA, and actin. Type I domain (FN1) is approximately40 residues in length. Four conserved cysteines are involved in disulphide bonds. The 3Dstructure of the FN1 domain has been determined [, , ]. It consists of two antiparallelβ-sheets, first a double-stranded one, that is linked by a disulphide bond to atriple-stranded β-sheet. The second conserved disulphide bridge links the C-terminaladjacent strands of the domain.In human tissue plasminogen activator chain A the FN1 domain together with thefollowing epidermal growth factor (EGF)-like domain are involved infibrin-binding []. It has been suggested that these two modules form a single structuraland functional unit []. The two domains keep their specific tertiary structure, but interactintimately to bury a hydrophobic core; the inter-module linker makes up the third strand ofthe EGF-module's major β-sheet.
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Publication
17982023 | J:153875
First Author: Kramer JM
Year: 2007
Journal: J Immunol
Title: Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor.
Volume: 179
Issue: 10
Pages: 6379-83
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Publication
34516771 | J:314197
First Author: Monteith AJ
Year: 2021
Journal: Sci Adv
Title: Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens.
Volume: 7
Issue: 37
Pages: eabj2101
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Publication
34516901 | J:314198
First Author: Pace JA
Year: 2021
Journal: Sci Adv
Title: Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney.
Volume: 7
Issue: 36
Pages: eabg6600
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Publication
7661397 | J:28624
First Author: Montgomery GW
Year: 1995
Journal: Anim Genet
Title: Sheep linkage mapping: RFLP markers for comparative mapping studies.
Volume: 26
Issue: 4
Pages: 249-59
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Protein Domain
IPR026280 | Tissue_plasm_act
Type: Family
Description: Tissue-type plasminogen activator is a serine peptidase belonging to MEROPS peptidase family S1 (chymotrypsin family, clan PA(S)), subfamily S1A.The fibrinolytic system is the mechanism by which blood clots are dissolved via the plasmin-mediated degradation of fibrin into soluble end products. The system is activated by urokinase-type plasminogen activator (uPA; ) or by tissue-type plasminogen activator (tPA; ; this family), which are enzymes that convert the inactive proenzyme plasminogen to the active protease plasmin [].tPA is mainly involved in the activation of circulating plasminogen, while uPA activates cell-bound plasminogen after binding to a specific uPA receptor (uPAR).Following the signal sequence and propeptide regions, tPA typically contains a fibronectin type I (FN1) domain, an EGF-type domain, two kringle domains and a trypsin domain. However, there are members missing FN1 or EGF or one of the kringles.This entry also includes salivary plaminogen activators from the vampire bat (Desmodus rotundus).
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Publication
28823555 | J:252495
First Author: Roy DS
Year: 2017
Journal: Cell
Title: Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories.
Volume: 170
Issue: 5
Pages: 1000-1012.e19
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Publication
37751458 | J:341194
First Author: Möckel T
Year: 2023
Journal: PLoS One
Title: Transcriptome analysis of renal ischemia/reperfusion (I/R) injury in BAFF and BAFF-R deficient mice.
Volume: 18
Issue: 9
Pages: e0291619
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Publication
2246770 | J:200892
First Author: Asher JH Jr
Year: 1990
Journal: J Med Genet
Title: Mouse and hamster mutants as models for Waardenburg syndromes in humans.
Volume: 27
Issue: 10
Pages: 618-26
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Publication
22956607 | J:214056
First Author: Matthaei M
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy.
Volume: 53
Issue: 10
Pages: 6718-27
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Publication
28011198 | J:250128
 
First Author: Hu K
Year: 2017
Journal: Matrix Biol
Title: Cell autonomous ANTXR1-mediated regulation of extracellular matrix components in primary fibroblasts.
Volume: 62
Pages: 105-114
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Publication
28679671 | J:312314
First Author: Montgomery TA
Year: 2017
Journal: J Am Soc Nephrol
Title: Breast Regression Protein-39/Chitinase 3-Like 1 Promotes Renal Fibrosis after Kidney Injury via Activation of Myofibroblasts.
Volume: 28
Issue: 11
Pages: 3218-3226
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Publication
8000137 | J:20128
First Author: Beever JE
Year: 1994
Journal: Mamm Genome
Title: A genetic map of nine loci on bovine chromosome 2.
Volume: 5
Issue: 9
Pages: 542-5
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Publication
38602508 | J:347134
 
First Author: Feng X
Year: 2024
Journal: Development
Title: Apical expansion of calvarial osteoblasts and suture patency is dependent on fibronectin cues.
Volume: 151
Issue: 7
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Publication
11460480 | -
 
First Author: Lijnen HR
Year: 2001
Journal: Ann N Y Acad Sci
Title: Elements of the fibrinolytic system.
Volume: 936
Pages: 226-36
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Publication
28536261 | J:246047
First Author: McDaniel K
Year: 2017
Journal: J Biol Chem
Title: The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury.
Volume: 292
Issue: 27
Pages: 11336-11347
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Publication
33692098 | J:306618
 
First Author: Mao M
Year: 2021
Journal: Dis Model Mech
Title: Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome.
Volume: 14
Issue: 4
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Publication
37075968 | J:336756
 
First Author: Yang D
Year: 2023
Journal: Exp Neurol
Title: Evidence that enolase-phosphatase 1 exacerbates early cerebral ischemia injury and blood-brain barrier breakdown by enhancing extracellular matrix destruction and inhibiting the interaction between ADI1 and MT1-MMP.
Volume: 365
Pages: 114410
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Protein
Q3UZF9
Organism: Mus musculus/domesticus
Length: 1055  
Fragment?: true
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Protein
Q3UHR1
Organism: Mus musculus/domesticus
Length: 1920  
Fragment?: true
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Protein
Q8R3F3
Organism: Mus musculus/domesticus
Length: 810  
Fragment?: true
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Protein
P11276
Organism: Mus musculus/domesticus
Length: 2477  
Fragment?: false
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Protein
Q3UH17
Organism: Mus musculus/domesticus
Length: 2266  
Fragment?: false
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Protein
B7ZNJ1
Organism: Mus musculus/domesticus
Length: 2176  
Fragment?: false
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Protein
B9EHT6
Organism: Mus musculus/domesticus
Length: 2271  
Fragment?: false
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Protein
Q3TCL7
Organism: Mus musculus/domesticus
Length: 1331  
Fragment?: true
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Protein
Q3UGY5
Organism: Mus musculus/domesticus
Length: 2386  
Fragment?: false
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Protein
A0A087WR50
Organism: Mus musculus/domesticus
Length: 2386  
Fragment?: false
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Protein
A0A087WS56
Organism: Mus musculus/domesticus
Length: 2266  
Fragment?: false
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Protein
Q3TCF1
Organism: Mus musculus/domesticus
Length: 2296  
Fragment?: false
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Protein
A0A087WSN6
Organism: Mus musculus/domesticus
Length: 2296  
Fragment?: false
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Protein
Q3TBB4
Organism: Mus musculus/domesticus
Length: 1832  
Fragment?: true
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Protein
Q3UHL6
Organism: Mus musculus/domesticus
Length: 2361  
Fragment?: false
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Protein
P11214
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
Q9R098
Organism: Mus musculus/domesticus
Length: 653  
Fragment?: false
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Protein
Q80YC5
Organism: Mus musculus/domesticus
Length: 597  
Fragment?: false
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Protein
Q3TDU8
Organism: Mus musculus/domesticus
Length: 653  
Fragment?: false
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Protein
Q8VCS4
Organism: Mus musculus/domesticus
Length: 653  
Fragment?: false
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Protein
Q545J3
Organism: Mus musculus/domesticus
Length: 653  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom