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Search results 301 to 400 out of 409 for Poli

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2.728s

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Type Details Score
Publication
29074498 | J:259065
First Author: Truman-Rosentsvit M
Year: 2018
Journal: Blood
Title: Ferritin is secreted via 2 distinct nonclassical vesicular pathways.
Volume: 131
Issue: 3
Pages: 342-352
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Publication
35838338 | J:333766
First Author: Pires-Afonso Y
Year: 2022
Journal: Mol Oncol
Title: Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency.
Volume: 16
Issue: 17
Pages: 3167-3191
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Publication
20201032 | J:267888
First Author: Hoelbl A
Year: 2010
Journal: EMBO Mol Med
Title: Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia.
Volume: 2
Issue: 3
Pages: 98-110
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Publication
27301576 | J:239890
 
First Author: Fagnocchi L
Year: 2016
Journal: Nat Commun
Title: A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity.
Volume: 7
Pages: 11903
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Publication
35181688 | J:343960
First Author: Tsoyi K
Year: 2022
Journal: Sci Rep
Title: Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts.
Volume: 12
Issue: 1
Pages: 2847
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Publication
31840053 | -
First Author: Raredon MSB
Year: 2019
Journal: Sci Adv
Title: Single-cell connectomic analysis of adult mammalian lungs.
Volume: 5
Issue: 12
Pages: eaaw3851
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Protein
A0A1Y7VK37
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: false
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Protein Domain
IPR021752 | TF_Rrn7_Zf
Type: Domain
Description: This entry represents the zinc-finger found in the N terminus of the Rrn7 protein. Rrn7 is a transcription binding factor that associates strongly with both Rrn6 and Rrn11 to form a complex which itself binds the TATA-binding protein and is required for transcription by the core domain of the RNA PolI promoter [, ].
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Allele
Polh<tm1.1Rak> | MGI:3614412
Name: polymerase (DNA directed), eta (RAD 30 related); targeted mutation 1.1, Raju Kucherlapati
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:6142888 | C57BL/6-Poli<tm1Pjg>/Mmucd
Attribute String: mutant strain, coisogenic, chemically induced mutation
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Publication
25974216 | J:223311
   
First Author: Yang R
Year: 2015
Journal: Elife
Title: Mitochondrial Ca²⁺ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function.
Volume: 4
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Publication
16751774 | J:112664
First Author: Hirai H
Year: 2006
Journal: Nat Immunol
Title: C/EBPbeta is required for 'emergency' granulopoiesis.
Volume: 7
Issue: 7
Pages: 732-9
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Publication
12456789 | J:125450
First Author: Grimm SL
Year: 2002
Journal: Mol Endocrinol
Title: Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development.
Volume: 16
Issue: 12
Pages: 2675-91
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Publication
32795415 | J:328941
First Author: Ndoja A
Year: 2020
Journal: Cell
Title: Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.
Volume: 182
Issue: 5
Pages: 1156-1169.e12
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Publication
32323921 | J:294705
First Author: Oberhuber M
Year: 2020
Journal: Mol Syst Biol
Title: STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer.
Volume: 16
Issue: 4
Pages: e9247
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Publication
27670591 | J:237259
First Author: Yang R
Year: 2016
Journal: J Exp Med
Title: IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells.
Volume: 213
Issue: 11
Pages: 2281-2291
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Publication
9688988 | J:48865
First Author: Leon LR
Year: 1998
Journal: Am J Physiol
Title: Role of IL-6 and TNF in thermoregulation and survival during sepsis in mice.
Volume: 275
Issue: 1 Pt 2
Pages: R269-77
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Publication
25283994 | J:217705
First Author: Sargeant TJ
Year: 2014
Journal: Nat Cell Biol
Title: Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization.
Volume: 16
Issue: 11
Pages: 1057-1068
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Publication
24398427 | J:320713
First Author: Stuart E
Year: 2014
Journal: Mol Cancer Ther
Title: Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice.
Volume: 13
Issue: 2
Pages: 468-74
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Publication
24983622 | J:218939
First Author: Robker RL
Year: 2014
Journal: PLoS One
Title: Identification of sites of STAT3 action in the female reproductive tract through conditional gene deletion.
Volume: 9
Issue: 7
Pages: e101182
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Publication
12509437 | J:91064
First Author: Wuestefeld T
Year: 2003
Journal: J Biol Chem
Title: Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration.
Volume: 278
Issue: 13
Pages: 11281-8
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Genotype
Genotype
Symbol: Stat3/Stat3 Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA * BALB/cAn
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Stat3/Stat3 Speer6-ps1/Speer6-ps1<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
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Publication
8057832 | J:20760
First Author: Reeder RH
Year: 1994
Journal: Mol Microbiol
Title: The mechanism of transcription termination by RNA polymerase I.
Volume: 12
Issue: 1
Pages: 11-5
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Strain
MGI:3717182 | B6;129-Polh<tm1.1Rak>/Nci
Attribute String: targeted mutation, mutant stock
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Publication
18381412 | J:133309
First Author: Busuttil RA
Year: 2008
Journal: Cancer Res
Title: Mutation frequencies and spectra in DNA polymerase eta-deficient mice.
Volume: 68
Issue: 7
Pages: 2081-4
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Publication
26240351 | J:226564
First Author: Chen YW
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities.
Volume: 112
Issue: 33
Pages: E4556-64
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Publication
16585153 | J:108222
First Author: Hagendoorn J
Year: 2006
Journal: Cancer Res
Title: Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Volume: 66
Issue: 7
Pages: 3360-4
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Genotype
Genotype
Symbol: Polh/Polh
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Polh/Polh<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Publication
35148201 | J:339093
First Author: Davidson S
Year: 2022
Journal: Sci Immunol
Title: Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24.
Volume: 7
Issue: 68
Pages: eabi6763
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Publication
36049541 | J:330382
     
First Author: De Logu F
Year: 2022
Journal: J Invest Dermatol
Title: miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4.
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Publication
23291536 | J:214204
 
First Author: Parmentier-Batteur S
Year: 2014
Journal: Neuropharmacology
Title: Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.
Volume: 82
Pages: 161-73
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Publication
26837764 | J:231629
First Author: Thiem S
Year: 2016
Journal: Cancer Res
Title: Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model.
Volume: 76
Issue: 8
Pages: 2277-87
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Publication
26595889 | J:234689
First Author: Rankin LC
Year: 2016
Journal: Nat Immunol
Title: Complementarity and redundancy of IL-22-producing innate lymphoid cells.
Volume: 17
Issue: 2
Pages: 179-86
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Publication
20585009 | J:178593
First Author: Hilfiker-Kleiner D
Year: 2010
Journal: Circulation
Title: Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction.
Volume: 122
Issue: 2
Pages: 145-55
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Publication
21816364 | J:175859
First Author: Hoch M
Year: 2011
Journal: Cell Stem Cell
Title: Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies.
Volume: 9
Issue: 2
Pages: 131-43
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Publication
27524624 | J:236983
First Author: Aden K
Year: 2016
Journal: Cell Rep
Title: Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.
Volume: 16
Issue: 8
Pages: 2208-2218
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Publication
30585358 | J:272499
First Author: Rakers C
Year: 2019
Journal: Glia
Title: Stroke target identification guided by astrocyte transcriptome analysis.
Volume: 67
Issue: 4
Pages: 619-633
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Publication
25512545 | J:216928
First Author: Jiang K
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models.
Volume: 111
Issue: 52
Pages: E5716-23
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Publication
33637536 | J:335838
 
First Author: Dodd GT
Year: 2021
Journal: Sci Adv
Title: Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance.
Volume: 7
Issue: 9
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Publication
21960530 | J:177869
First Author: Harker JA
Year: 2011
Journal: Science
Title: Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection.
Volume: 334
Issue: 6057
Pages: 825-9
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Publication
18805458 | J:155075
First Author: Sims NA
Year: 2009
Journal: Mol Cell Endocrinol
Title: gp130 signaling in bone cell biology: multiple roles revealed by analysis of genetically altered mice.
Volume: 310
Issue: 1-2
Pages: 30-9
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Publication
32238474 | J:328906
First Author: Viau A
Year: 2020
Journal: J Am Soc Nephrol
Title: Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease.
Volume: 31
Issue: 5
Pages: 1035-1049
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Publication
30454647 | J:267427
First Author: Grohmann M
Year: 2018
Journal: Cell
Title: Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.
Volume: 175
Issue: 5
Pages: 1289-1306.e20
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Genotype
Genotype
Symbol: Ptpn11/Ptpn11 Stat3/Stat3 Speer6-ps1/Speer6-ps1<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
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Publication
35148840 | J:337169
First Author: Borriello F
Year: 2022
Journal: Cell
Title: An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.
Volume: 185
Issue: 4
Pages: 614-629.e21
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Publication
16397220 | J:105034
First Author: Lin Q
Year: 2006
Journal: Cancer Res
Title: Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice.
Volume: 66
Issue: 1
Pages: 87-94
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Publication
22733395 | J:193520
First Author: Brun J
Year: 2013
Journal: Int J Cancer
Title: Oncolytic Vaccinia virus safely and effectively treats skin tumors in mouse models of xeroderma pigmentosum.
Volume: 132
Issue: 3
Pages: 726-31
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Publication
35440634 | J:325750
First Author: Fleig S
Year: 2022
Journal: Nat Commun
Title: Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.
Volume: 13
Issue: 1
Pages: 2022
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Protein
P97358
Organism: Mus musculus/domesticus
Length: 586  
Fragment?: false
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Publication
8887672 | -
First Author: Lin CW
Year: 1996
Journal: Mol Cell Biol
Title: A novel 66-kilodalton protein complexes with Rrn6, Rrn7, and TATA-binding protein to promote polymerase I transcription initiation in Saccharomyces cerevisiae.
Volume: 16
Issue: 11
Pages: 6436-43
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Publication
30700914 | J:278479
First Author: Gronke K
Year: 2019
Journal: Nature
Title: Interleukin-22 protects intestinal stem cells against genotoxic stress.
Volume: 566
Issue: 7743
Pages: 249-253
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Publication
26006013 | J:260611
First Author: Hernández PP
Year: 2015
Journal: Nat Immunol
Title: Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.
Volume: 16
Issue: 7
Pages: 698-707
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Publication
27578791 | J:237343
First Author: Laresgoiti U
Year: 2016
Journal: Development
Title: Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate.
Volume: 143
Issue: 20
Pages: 3686-3699
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Publication
21204268 | J:232020
First Author: Ermakova O
Year: 2011
Journal: EMBO Mol Med
Title: Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.
Volume: 3
Issue: 1
Pages: 50-66
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Publication
9288107 | -
First Author: Gray MD
Year: 1997
Journal: Nat Genet
Title: The Werner syndrome protein is a DNA helicase.
Volume: 17
Issue: 1
Pages: 100-3
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Publication
9697700 | -
First Author: Yan H
Year: 1998
Journal: Nat Genet
Title: Replication focus-forming activity 1 and the Werner syndrome gene product.
Volume: 19
Issue: 4
Pages: 375-8
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Publication
9224595 | -
First Author: Suzuki N
Year: 1997
Journal: Nucleic Acids Res
Title: DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.
Volume: 25
Issue: 15
Pages: 2973-8
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Publication
33926956 | -
First Author: Pezo V
Year: 2021
Journal: Science
Title: Noncanonical DNA polymerization by aminoadenine-based siphoviruses.
Volume: 372
Issue: 6541
Pages: 520-524
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Publication
15377656 | -
First Author: Andraos N
Year: 2004
Journal: J Biol Chem
Title: The highly processive DNA polymerase of bacteriophage T5. Role of the unique N and C termini.
Volume: 279
Issue: 48
Pages: 50609-18
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Publication
7958901 | -
First Author: Keys DA
Year: 1994
Journal: Genes Dev
Title: RRN6 and RRN7 encode subunits of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae.
Volume: 8
Issue: 19
Pages: 2349-62
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Protein Domain
IPR002562 | 3'-5'_exonuclease_dom
Type: Domain
Description: This entry represents the domain that is responsible for the 3'-5' exonuclease proofreading activity of Escherichia coli DNA polymerase I (polI) and other enzymes which catalyse the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI and is also found in the Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (also known as Werner syndrome helicase), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D) [].Werner syndrome is a human genetic disorder causing premature ageing; the WRN protein has helicase activity in the 3'-5' direction [, ]. The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homologue of the WRN protein []. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.This domain is also found in some DNA polymerases from phages, including the DNA polymerase from Escherichia phage T5, exonucleolytic activity [], and the DNA polymerase DpoZ from Acinetobacter phage SH-Ab 15497, which preferentially incorporates the non-canonical base aminoadenine/dZTP instead of adenine into the synthesized DNA [].
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Protein Coding Gene
MGI:2146571 | Rfc4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97891 | Rfc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919401 | Rfc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1341868 | Rfc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916513 | Rfc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9D0F6
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: false
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Protein
Q9WUK4
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
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Protein
Q8R323
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
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Protein
P35601
Organism: Mus musculus/domesticus
Length: 1131  
Fragment?: false
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Protein
Q99J62
Organism: Mus musculus/domesticus
Length: 364  
Fragment?: false
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Protein Coding Gene
MGI:1915525 | Rpa1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97503 | Pcna
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1339939 | Rpa2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915490 | Rpa3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P17918
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q9CQ71
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
Q62193
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
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Protein
Q8VEE4
Organism: Mus musculus/domesticus
Length: 623  
Fragment?: false
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Publication
32428860 | J:336999
First Author: Riedelberger M
Year: 2020
Journal: iScience
Title: Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion.
Volume: 23
Issue: 5
Pages: 101121
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Protein
Q8CDF7
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
Q8VEG4
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
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Protein
Q3TZ13
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: true
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Protein
B2RWQ8
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
Q3UIJ1
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
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Protein
A0A1W2P7Q1
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
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Publication
29688375 | J:250512
   
First Author: Li J
Year: 2018
Journal: Database (Oxford)
Title: CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.
Volume: 2018
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Protein
Q3TRD0
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: true
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Protein
Q99KY7
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: true
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Protein
P56960
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Protein
Q9CYJ3
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: false
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Protein
O35948
Organism: Mus musculus/domesticus
Length: 643  
Fragment?: false
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Protein
Q8R2R0
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Protein
F6VYQ6
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
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Protein
Q3UNK6
Organism: Mus musculus/domesticus
Length: 887  
Fragment?: false
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Protein
Q8K366
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3TMV6
Organism: Mus musculus/domesticus
Length: 789  
Fragment?: false
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Protein
Q3TB25
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom