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Search results 1 to 2 out of 2 for Tacc2

Category restricted to ProteinDomain (x)

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Category: ProteinDomain
Type Details Score
Protein Domain
Type: Family
Description: The TACC protein family localises to the centrosome (the spindle pole body in fungi) and mitotic spindle, and plays a crucial role in bipolar spindle assembly [, ]. Furthermore, Alp7/TACC recruits kinesin-8-PP1 to the kinetochore to regulate timely mitotic progression and chromosome movement during anaphase A [].There is only one TACC protein in the nematode Caenorhabditis elegans (TAC-1), in Drosophila melanogaster (D-TACC), in Xenopus laevis (Maskin), and in fission yeast (Alp7 also known as Mia1p); by contrast, mammals have three TACC proteins (TACC1, TACC2 and TACC3) [].
Protein Domain
Type: Domain
Description: This entry represents a C-terminal domain found in the the proteins TACC 1, 2 and 3 (TACC1-3). TACC1 is found concentrated in the centrosomes of eukaryotes which may play a conserved role in organising centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1) []. TACC 3 from Xenopus laevis, also known as maskin, associates XMAP215 and promotes efficient microtubule elongation during mitosis []. Maskin is also found to bind CPEB and elF-4E []. Interestingly, the functional homologue (Alp7) in Schizosaccharomyces pombe (not included in this entry) has been shown to be required for organisation of bipolar spindles [].