This entry represents AF1q, encoded by the MLLT11 gene, which is a fusion partner of the MLL (mixed lineage leukemia) gene. The MLL-MLLT11 fusion is linked to the acute leukemias [].At the protein level, AF1q/MLLT11 is highly expressed in thymus and all leukemic cell lines, and is differentially expressed during neuronal differentiation [, ]. It interacts with the Notch signalling pathway to regulate the emergence of human prothymocytes []. It has also been shown that AF1q increases radiation-induced apoptosis through up-regulation of BAD (BCL-2 antagonist of cell death) in human squamous carcinoma via NF-kappaB [].
