ARHGEF2, also called GEF-H1, acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases []. It is thought to play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibres. ARHGEF2 contains a C1 domain followed by Dbl-homology (DH) and pleckstrin-homology (PH) domains which bind and catalyze the exchange of GDP for GTP on RhoA []. This entry represents the PH domain of ARHGEF2.
