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Search results 301 to 400 out of 425 for Trem2

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Type Details Score
Publication
33951432 | J:324649
First Author: Eyo UB
Year: 2021
Journal: Cell Rep
Title: Microglia provide structural resolution to injured dendrites after severe seizures.
Volume: 35
Issue: 5
Pages: 109080
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Publication
34262178 | J:335093
First Author: McAlpine CS
Year: 2021
Journal: Nature
Title: Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.
Volume: 595
Issue: 7869
Pages: 701-706
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Publication
29694903 | J:271131
First Author: Eyo UB
Year: 2018
Journal: Cell Rep
Title: P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape.
Volume: 23
Issue: 4
Pages: 959-966
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Publication
35813947 | J:341528
 
First Author: Oblak AL
Year: 2022
Journal: Front Aging Neurosci
Title: Plcg2(M28L) Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in Mice.
Volume: 14
Pages: 886575
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Publication
18685038 | J:140167
First Author: Wakselman S
Year: 2008
Journal: J Neurosci
Title: Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor.
Volume: 28
Issue: 32
Pages: 8138-43
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Publication
25897174 | J:222695
First Author: Wu K
Year: 2015
Journal: J Exp Med
Title: TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.
Volume: 212
Issue: 5
Pages: 681-97
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Publication
33606969 | J:306947
First Author: Safaiyan S
Year: 2021
Journal: Neuron
Title: White matter aging drives microglial diversity.
Volume: 109
Issue: 7
Pages: 1100-1117.e10
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Publication
32579115 | J:292138
   
First Author: Burns JC
Year: 2020
Journal: Elife
Title: Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain.
Volume: 9
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Publication
21841309 | J:178250
First Author: Barrow AD
Year: 2011
Journal: J Clin Invest
Title: OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.
Volume: 121
Issue: 9
Pages: 3505-16
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Publication
15128777 | J:89867
First Author: Terme M
Year: 2004
Journal: J Immunol
Title: IL-4 confers NK stimulatory capacity to murine dendritic cells: a signaling pathway involving KARAP/DAP12-triggering receptor expressed on myeloid cell 2 molecules.
Volume: 172
Issue: 10
Pages: 5957-66
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Publication
22522930 | J:183995
First Author: Hayashi M
Year: 2012
Journal: Nature
Title: Osteoprotection by semaphorin 3A.
Volume: 485
Issue: 7396
Pages: 69-74
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Publication
30930146 | J:284496
First Author: Wang ECE
Year: 2019
Journal: Cell Stem Cell
Title: A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth.
Volume: 24
Issue: 4
Pages: 654-669.e6
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Publication
30606613 | J:270443
First Author: Li Q
Year: 2019
Journal: Neuron
Title: Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing.
Volume: 101
Issue: 2
Pages: 207-223.e10
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Publication
29798841 | J:277787
First Author: Ikuta K
Year: 2019
Journal: Gut
Title: Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.
Volume: 68
Issue: 5
Pages: 882-892
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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21308776 | J:233118
First Author: Abdallah BM
Year: 2011
Journal: J Bone Miner Res
Title: DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.
Volume: 26
Issue: 7
Pages: 1457-71
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Publication
30635555 | J:270210
First Author: Loo L
Year: 2019
Journal: Nat Commun
Title: Single-cell transcriptomic analysis of mouse neocortical development.
Volume: 10
Issue: 1
Pages: 134
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Allele
Trem2<em3Bwef> | MGI:6295472
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 3, Benedikt Wefers
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Trem2<em1Gbu> | MGI:7539739
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Guojun Bu
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Trem2<em2Adiuj> | MGI:5695000
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 2, MODEL-AD Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Trem2<em1Tcp> | MGI:6739869
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, The Centre for Phenogenomics
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Trem2<tm1.1Cya> | MGI:7516532
Name: triggering receptor expressed on myeloid cells 2; targeted mutation 1.1, Cyagen Biosciences
Allele Type: Targeted
Attribute String: Humanized sequence
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HT Experiment
GSE200842 | Transcriptomic analysis of injured and uninjured knee joints from Trem2 KO mice [bulk RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
36107206 | J:341604
 
First Author: Zhao N
Year: 2022
Journal: J Exp Med
Title: Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia.
Volume: 219
Issue: 12
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HT Experiment
GSE181135 | Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE185510 | Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology [14 months]
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Allele
Trem2<em3Adiuj> | MGI:5816607
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 3, MODEL-AD Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Publication
37035000 | J:339336
First Author: Iguchi A
Year: 2023
Journal: iScience
Title: INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model.
Volume: 26
Issue: 4
Pages: 106375
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HT Experiment
GSE123022 | Deep single-cell RNAseq of postnatal day 7 microglia from wild type and Trem2 knockout brains
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
18551625 | J:156263
First Author: Frank S
Year: 2008
Journal: Glia
Title: TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice.
Volume: 56
Issue: 13
Pages: 1438-47
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Publication
37865646 | J:342080
First Author: Zhang X
Year: 2023
Journal: Nat Commun
Title: Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease.
Volume: 14
Issue: 1
Pages: 6670
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Publication
33065553 | J:311239
First Author: Wang Y
Year: 2020
Journal: Aging (Albany NY)
Title: TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice.
Volume: 12
Issue: 20
Pages: 20862-20879
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Publication
31006066 | J:295793
First Author: Boza-Serrano A
Year: 2019
Journal: Acta Neuropathol
Title: Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.
Volume: 138
Issue: 2
Pages: 251-273
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Publication
32514138 | J:298292
First Author: Andreone BJ
Year: 2020
Journal: Nat Neurosci
Title: Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia.
Volume: 23
Issue: 8
Pages: 927-938
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Publication
26021803 | J:232902
First Author: Phongsisay V
Year: 2015
Journal: Mol Immunol
Title: Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors.
Volume: 66
Issue: 2
Pages: 463-71
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Publication
28197095 | J:276720
 
First Author: Brendel M
Year: 2017
Journal: Front Aging Neurosci
Title: Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis.
Volume: 9
Pages: 8
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Allele
Trem2<em3Smoc> | MGI:7292958
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Trem2<em5Smoc> | MGI:7292960
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 5, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Allele
Trem2<em1Adiuj> | MGI:5770794
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, MODEL-AD Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Publication
28612290 | J:311298
First Author: Haure-Mirande JV
Year: 2017
Journal: Acta Neuropathol
Title: Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
Volume: 134
Issue: 5
Pages: 769-788
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Allele
Trem2<em4(TREM2)Smoc> | MGI:7292959
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 4, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:6355304 | C57BL/6J-Trem2<em3Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6771235 | C57BL/6-Trem2<em5Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
29611543 | -
First Author: Zhao Y
Year: 2017
Journal: Exp Mol Med
Title: Intracellular trafficking of TREM2 is regulated by presenilin 1.
Volume: 49
Issue: 12
Pages: e405
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Strain
MGI:6429726 | C57BL/6J-Trem2<em4(TREM2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Allele
Trem2<em1(cre)Jddl> | MGI:7490214
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Jiandie D Lin
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
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Allele
Trem2<em1Smoc> | MGI:7292956
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6355300 | C57BL/6J-Trem2<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Trem2<em2Smoc> | MGI:7292957
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
27477018 | -
First Author: Yeh FL
Year: 2016
Journal: Neuron
Title: TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.
Volume: 91
Issue: 2
Pages: 328-40
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Allele
Gt(ROSA)26Sor<tm3(tTA,tetO-TREM2,-EGFP)Gbu> | MGI:7541478
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Guojun Bu
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Inserted expressed sequence, No functional change
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HT Experiment
GSE140399 | Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and -independent cellular responses in Alzheimer's disease [15 months]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE140510 | Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and -independent cellular responses in Alzheimer's disease [7 months]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Gt(ROSA)26Sor<tm4(tTA,tetO-TREM2*R47H,-EGFP)Gbu> | MGI:7541481
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Guojun Bu
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Inserted expressed sequence, Reporter
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Strain
MGI:6355303 | C57BL/6J-Trem2<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Trem2<em1Npa> | MGI:7507636
 
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Novartis Pharma AG
Allele Type: Endonuclease-mediated
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Strain
MGI:6491423 | C57BL/6J-Trem2<em3Bwef>/J
Attribute String: endonuclease-mediated mutation, mutant strain, coisogenic
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Allele
Trem2<em3Npa> | MGI:7509136
 
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 3, Novartis Pharma AG
Allele Type: Endonuclease-mediated
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Allele
Trem2<tm1(TREM2*R47H)Aduci> | MGI:7327131
Name: triggering receptor expressed on myeloid cells 2; targeted mutation 1, Frank LaFerla
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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HT Experiment
GSE204769 | Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination [Trem2KO]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:7327132 | C57BL/6J-Trem2<tm2(TREM2*R47H)Aduci>
Attribute String: coisogenic, mutant strain, targeted mutation
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Allele
Trem2<em2(TREM2*R47H)Aduci> | MGI:7327122
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 2, Frank LaFerla
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(TREM2)1Xwy | MGI:6194033
Name: transgene insertion 1, X William Yang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:7485950 | C57BL/6J-Trem2<em2(TREM2*R47H)Aduci>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7327123 | C57BL/6-Trem2<em2(TREM2*R47H)Aduci>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6194058 | FVB/NJ-Tg(TREM2)1Xwy/J
Attribute String: transgenic, mutant strain, coisogenic
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Trem2/Trem2<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
25620700 | J:222897
First Author: Matarin M
Year: 2015
Journal: Cell Rep
Title: A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology.
Volume: 10
Issue: 4
Pages: 633-44
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Publication
33314529 | J:331908
First Author: Audrain M
Year: 2021
Journal: Alzheimers Dement
Title: Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.
Volume: 17
Issue: 2
Pages: 149-163
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