NOBOX is an oocyte-specific transcription factor essential for folliculogenesis and expression of many germ cell-specific genes in mice []. It regulates the expression of Pad6, a peptidylarginine deiminase in the oocyte []. It has also been shown to function in regulation of embryonic genome activation, pluripotency gene expression, and blastocyst cell allocation in cattle []. Mutations of the NOBOX gene have been linked to primary ovarian insufficiency [, , ].
