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Search results 101 to 200 out of 201 for Blk

0.034s
Type Details Score
GXD Expression  
Probe: MGI:4882190
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945799
Age: postnatal day 7
Image: g01583 P7
Specimen Label: g01583 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4882190
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945799
Age: postnatal day 42
Image: g01583 Adult
Specimen Label: g01583 Adult
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5617773
Assay Type: Immunohistochemistry
Annotation Date: 2015-03-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5618168
Age: embryonic day 8.5
Specimen Label: not shown E8
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4882190
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945799
Age: postnatal day 7
Image: g01583 P7
Specimen Label: g01583 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4882190
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945799
Age: postnatal day 42
Image: g01583 Adult
Specimen Label: g01583 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4882190
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945799
Age: embryonic day 15.5
Image: g01583 E15.5
Specimen Label: g01583 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4882190
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945799
Age: postnatal day 7
Image: g01583 P7
Specimen Label: g01583 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4882190
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945799
Age: postnatal day 42
Image: g01583 Adult
Specimen Label: g01583 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4882190
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945799
Age: embryonic day 15.5
Image: g01583 E15.5
Specimen Label: g01583 E15.5
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692982
Age: postnatal adult
Image: UC Davis_1870816
Specimen Label: UC Davis_1870816
Detected: true
Specimen Num: 10
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692982
Age: postnatal adult
Image: UC Davis_1870819
Specimen Label: UC Davis_1870819
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692982
Age: postnatal adult
Image: UC Davis_1870812
Specimen Label: UC Davis_1870812
Detected: true
Specimen Num: 6
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692982
Age: postnatal adult
Image: UC Davis_1870813
Specimen Label: UC Davis_1870813
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4882190
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945799
Age: embryonic day 15.5
Image: g01583 E15.5
Specimen Label: g01583 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4882190
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945799
Age: postnatal day 7
Image: g01583 P7
Specimen Label: g01583 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4882190
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945799
Age: postnatal day 42
Image: g01583 Adult
Specimen Label: g01583 Adult
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5617773
Assay Type: Immunohistochemistry
Annotation Date: 2015-03-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Not Specified
Stage: TS02
Assay Id: MGI:5618168
Age: embryonic day 1.0
Specimen Label: not shown 2-cell
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5617773
Assay Type: Immunohistochemistry
Annotation Date: 2015-03-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5618168
Age: embryonic day 12.5
Specimen Label: not shown E12
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:5617773
Assay Type: Immunohistochemistry
Annotation Date: 2015-03-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5618168
Age: embryonic day 10.5
Specimen Label: not shown E10
Detected: true
Specimen Num: 4
Publication
First Author: Clise-Dwyer K
Year: 2001
Journal: Immunogenetics
Title: Genetic studies of B-lymphocyte deficiency and mastocytosis in strain A/WySnJ mice.
Volume: 53
Issue: 9
Pages: 729-35
Publication
First Author: Bao Y
Year: 2012
Journal: J Biol Chem
Title: Tyrosine kinase Btk is required for NK cell activation.
Volume: 287
Issue: 28
Pages: 23769-78
Publication
First Author: Rovedo M
Year: 2008
Journal: J Virol
Title: Epstein-Barr virus latent membrane protein 2A preferentially signals through the Src family kinase Lyn.
Volume: 82
Issue: 17
Pages: 8520-8
Publication
First Author: Malek SN
Year: 1996
Journal: J Biol Chem
Title: p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains.
Volume: 271
Issue: 12
Pages: 6952-62
Publication
First Author: Chan VW
Year: 1998
Journal: J Exp Med
Title: The molecular mechanism of B cell activation by toll-like receptor protein RP-105.
Volume: 188
Issue: 1
Pages: 93-101
Publication
First Author: Kojima T
Year: 2000
Journal: J Biol Chem
Title: TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles.
Volume: 275
Issue: 27
Pages: 20742-7
Publication
First Author: Alexandropoulos K
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Proline-rich sequences that bind to Src homology 3 domains with individual specificities.
Volume: 92
Issue: 8
Pages: 3110-4
Publication
First Author: Zwollo P
Year: 1994
Journal: J Biol Chem
Title: Specific recognition of the blk promoter by the B-lymphoid transcription factor B-cell-specific activator protein.
Volume: 269
Issue: 21
Pages: 15310-7
Publication
First Author: Zwollo P
Year: 1998
Journal: J Biol Chem
Title: The transcription factor NF-kappaB/p50 interacts with the blk gene during B cell activation.
Volume: 273
Issue: 29
Pages: 18647-55
Publication
First Author: Oda H
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination.
Volume: 96
Issue: 17
Pages: 9557-62
Publication
First Author: Wang JP
Year: 1998
Journal: Biomed Res
Title: Expression of Src family during development of the mouse nervous system.
Volume: 19
Issue: 5
Pages: 315-325
Publication
First Author: Rinke de Wit TF
Year: 1996
Journal: Int Immunol
Title: Expression of tyrosine kinase gene in mouse thymic stromal cells.
Volume: 8
Issue: 11
Pages: 1787-95
Publication
First Author: O'Brien EP
Year: 1996
Journal: Mamm Genome
Title: High-resolution genetic mapping of the gunmetal gene which regulates platelet production.
Volume: 7
Issue: 3
Pages: 206-8
Publication
First Author: Lee CG
Year: 1999
Journal: Mamm Genome
Title: Genetic mapping of eight SH3 domain genes on seven mouse chromosomes.
Volume: 10
Issue: 4
Pages: 402-4
Publication
First Author: Tai G
Year: 2013
Journal: Biol Open
Title: FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique.
Volume: 2
Issue: 4
Pages: 416-23
Publication
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
Publication        
First Author: Haiming Tang, Dustin Ebert, Matthias Blum, Robert Finn, Paul Thomas
Year: 2023
Title: TreeGrafter-generated GO annotations
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication
First Author: Yao XR
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Antisense oligodeoxynucleotides to the blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell lymphoma.
Volume: 90
Issue: 17
Pages: 7946-50
Publication
First Author: Wasserman R
Year: 1995
Journal: J Immunol
Title: Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement.
Volume: 155
Issue: 2
Pages: 644-51
UniProt Feature
Begin: 2
Description: Tyrosine-protein kinase Blk
Type: chain
End: 499
Publication
First Author: Mahajan S
Year: 1995
Journal: Mol Cell Biol
Title: Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase.
Volume: 15
Issue: 10
Pages: 5304-11
Gene
Type: gene
Organism: frog, African clawed
Publication
First Author: Amanna IJ
Year: 2001
Journal: J Immunol
Title: Cutting edge: A/WySnJ transitional B cells overexpress the chromosome 15 proapoptotic Blk gene and succumb to premature apoptosis.
Volume: 167
Issue: 11
Pages: 6069-72
Protein
Organism: Mus musculus/domesticus
Length: 499  
Fragment?: false
Publication
First Author: Burkhardt AL
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.
Volume: 88
Issue: 16
Pages: 7410-4
Publication
First Author: Saouaf SJ
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.
Volume: 91
Issue: 20
Pages: 9524-8
Publication
First Author: Saouaf SJ
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate.
Volume: 234
Issue: 2
Pages: 325-9
Publication
First Author: Metzler WJ
Year: 1996
Journal: Biochemistry
Title: The three-dimensional solution structure of the SH2 domain from p55blk kinase.
Volume: 35
Issue: 20
Pages: 6201-11
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
Interaction Experiment
Description: Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells.
DO Term
Publication
First Author: Lee S
Year: 2002
Journal: Cancer Lett
Title: Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells.
Volume: 188
Issue: 1-2
Pages: 121-6
Publication
First Author: Brokhman I
Year: 2019
Journal: Dev Biol
Title: Dual embryonic origin of the mammalian enteric nervous system.
Volume: 445
Issue: 2
Pages: 256-270
Publication
First Author: Lin J
Year: 1992
Journal: J Immunol
Title: The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases.
Volume: 149
Issue: 5
Pages: 1548-55
Publication
First Author: Saouaf SJ
Year: 1995
Journal: J Biol Chem
Title: Reconstitution of the B cell antigen receptor signaling components in COS cells.
Volume: 270
Issue: 45
Pages: 27072-8
Protein Domain
Type: Domain
Description: Blk is a member of the Src non-receptor type tyrosine kinase family of proteins. Blk is involved in B-cell receptor signaling and B-cell development []. Unlike most other Src members Blk lacks cysteine residues in the SH4 domain that undergo palmitylation. Blk is required for the development of IL-17-producing gamma-delta T cells []. This entry represents the SH2 domain of Blk.The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs [].
Publication
First Author: Malhotra N
Year: 2013
Journal: Immunity
Title: A network of high-mobility group box transcription factors programs innate interleukin-17 production.
Volume: 38
Issue: 4
Pages: 681-93
Publication
First Author: Hegde R
Year: 1998
Journal: J Biol Chem
Title: Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.
Volume: 273
Issue: 14
Pages: 7783-6
Publication
First Author: Coultas L
Year: 2004
Journal: Mol Cell Biol
Title: Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death.
Volume: 24
Issue: 4
Pages: 1570-81
Publication
First Author: Kükenshöner T
Year: 2017
Journal: J Mol Biol
Title: Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
Volume: 429
Issue: 9
Pages: 1364-1380
Publication    
First Author: Matsubara T
Year: 2021
Journal: J Biol Chem
Title: Characterization of unique functionalities in c-Src domains required for osteoclast podosome belt formation.
Pages: 100790
Publication
First Author: Merluzzi S
Year: 2004
Journal: J Biol Chem
Title: CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism.
Volume: 279
Issue: 3
Pages: 1777-86
Publication
First Author: Zwollo P
Year: 1997
Journal: J Biol Chem
Title: The Pax-5 gene is alternatively spliced during B-cell development.
Volume: 272
Issue: 15
Pages: 10160-8
Publication
First Author: Masuki S
Year: 2013
Journal: J Physiol
Title: Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice.
Volume: 591
Issue: 14
Pages: 3651-65
Publication
First Author: Hatakeyama S
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: The murine c-fgr gene product associated with Ly6C and p70 integral membrane protein is expressed in cells of a monocyte/macrophage lineage.
Volume: 91
Issue: 8
Pages: 3458-62
Protein
Organism: Mus musculus/domesticus
Length: 499  
Fragment?: false
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89