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Search results 401 to 462 out of 462 for Frk

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:1415774
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824922
Age: embryonic day 14.5
Image: euxassay_003660_13
Specimen Label: euxassay_003660_13
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:1415774
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824922
Age: embryonic day 14.5
Image: euxassay_003660_14
Specimen Label: euxassay_003660_14
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
 
Probe: MGI:1415774
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824922
Age: embryonic day 14.5
Image: euxassay_003660_15
Specimen Label: euxassay_003660_15
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:1415774
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824922
Age: embryonic day 14.5
Image: euxassay_003660_16
Specimen Label: euxassay_003660_16
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:1415774
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824922
Age: embryonic day 14.5
Image: euxassay_003660_17
Specimen Label: euxassay_003660_17
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
 
Probe: MGI:1415774
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824922
Age: embryonic day 14.5
Image: euxassay_003660_18
Specimen Label: euxassay_003660_18
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:1415774
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824922
Age: embryonic day 14.5
Image: euxassay_003660_19
Specimen Label: euxassay_003660_19
Detected: true
Specimen Num: 19
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GXD Expression
GXD Expression
 
Probe: MGI:1415774
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824922
Age: embryonic day 14.5
Image: euxassay_003660_20
Specimen Label: euxassay_003660_20
Detected: true
Specimen Num: 20
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GXD Expression
GXD Expression
 
Probe: MGI:1415774
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824922
Age: embryonic day 14.5
Image: euxassay_003660_21
Specimen Label: euxassay_003660_21
Detected: true
Specimen Num: 21
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GXD Expression
GXD Expression
 
Probe: MGI:1415774
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824922
Age: embryonic day 14.5
Image: euxassay_003660_22
Specimen Label: euxassay_003660_22
Detected: true
Specimen Num: 22
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Publication
11786382 | J:74310
First Author: Annerén C
Year: 2002
Journal: J Endocrinol
Title: Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin.
Volume: 172
Issue: 1
Pages: 145-53
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UniProt Feature
UniProt Feature
Begin: 1
Description: Tyrosine-protein kinase FRK
Type: chain
End: 512
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UniProt Feature
UniProt Feature
Begin: 336
Description: Phosphotyrosine; by FRK
Type: modified residue
End: 336
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Publication
24206222 | J:208452
First Author: Sasaki Y
Year: 2014
Journal: Congenit Anom (Kyoto)
Title: Molecular contribution to cleft palate production in cleft lip mice.
Volume: 54
Issue: 2
Pages: 94-9
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Publication
23974039 | J:201587
First Author: Wang D
Year: 2013
Journal: Nat Cell Biol
Title: MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway.
Volume: 15
Issue: 10
Pages: 1153-63
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Publication
7542761 | J:27414
First Author: Sommers CL
Year: 1995
Journal: Oncogene
Title: Murine txk: a protein tyrosine kinase gene regulated by T cell activation.
Volume: 11
Issue: 2
Pages: 245-51
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Publication
11114734 | J:66153
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:345476
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q922K9
Organism: Mus musculus/domesticus
Length: 512  
Fragment?: false
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Publication
17179392 | J:120366
First Author: Annerén C
Year: 2007
Journal: Am J Physiol Endocrinol Metab
Title: Glucose intolerance and reduced islet blood flow in transgenic mice expressing the FRK tyrosine kinase under the control of the rat insulin promoter.
Volume: 292
Issue: 4
Pages: E1183-90
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Publication
7664264 | -
First Author: Craven RJ
Year: 1995
Journal: Cancer Res
Title: The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.
Volume: 55
Issue: 18
Pages: 3969-72
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Publication
19652529 | -
First Author: Brauer PM
Year: 2009
Journal: Cell Cycle
Title: RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.
Volume: 8
Issue: 17
Pages: 2728-32
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Publication
7696183 | -
First Author: Cance WG
Year: 1994
Journal: Cell Growth Differ
Title: Rak, a novel nuclear tyrosine kinase expressed in epithelial cells.
Volume: 5
Issue: 12
Pages: 1347-55
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Publication
12776987 | -
First Author: Annerén C
Year: 2003
Journal: Curr Mol Med
Title: The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation.
Volume: 3
Issue: 4
Pages: 313-24
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Protein Domain
IPR035805 | SH2_Frk
Type: Domain
Description: Frk (RAK) is a member of the Src non-receptor type tyrosine kinase family of proteins. The Frk subfamily is composed of Frk/Rak and Iyk/Bsk/Gst. It is expressed primarily epithelial cells. Frk is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth []. Unlike the other Src members it lacks a glycine at position 2 of SH4 which is important for addition of a myristic acid moiety that is involved in targeting Src PTKs to cellular membranes []. FRK and SHB exert similar effects when overexpressed in rat phaeochromocytoma (PC12) and beta-cells, where both induce PC12 cell differentiation and beta-cell proliferation. Under conditions that cause beta-cell degeneration these proteins augment beta-cell apoptosis. The FRK-SHB responses involve FAK and insulin receptor substrates (IRS) -1 and -2 []. Frk has been demonstrated to interact with retinoblastoma protein []. Frk regulates PTEN protein stability by phosphorylating PTEN, which in turn prevents PTEN degradation []. Frk also plays a role in regulation of embryonal pancreatic beta cell formation [].The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs [].
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Publication
28347651 | -
First Author: Kükenshöner T
Year: 2017
Journal: J Mol Biol
Title: Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
Volume: 429
Issue: 9
Pages: 1364-1380
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Publication
37523817 | J:342814
 
First Author: Kikuchi I
Year: 2023
Journal: Biochem Biophys Res Commun
Title: Coevolution of the ileum with Brk/Ptk6 family kinases confers robustness to ileal homeostasis.
Volume: 676
Pages: 190-197
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Protein
Q8BPC1
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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