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Search results 1 to 100 out of 1078 for Htt

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
3064 | HTT
Type: gene
Organism: human
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Gene
615059 | HTT
Type: gene
Organism: cattle
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Gene
422878 | HTT
Type: gene
Organism: chicken
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Gene
30214 | htt
Type: gene
Organism: zebrafish
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Gene
700306 | HTT
Type: gene
Organism: macaque, rhesus
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Gene
493287 | htt
Type: gene
Organism: frog, western clawed
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Gene
29424 | Htt
Type: gene
Organism: rat
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Gene
479074 | HTT
Type: gene
Organism: dog, domestic
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Gene
461084 | HTT
Type: gene
Organism: chimpanzee
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Strain
MGI:2162435 | HTT
Attribute String: strain family
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Protein Coding Gene
MGI:96067 | Htt
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
100750326 | HTT-AS
Type: gene
Organism: human
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GXD Expression
GXD Expression
   
Probe: MGI:7507085
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-14
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1909528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7507112
Age: postnatal week 9
Note: Expression in wildtype not described.
Specimen Label: 3a HTT
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7507085
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-14
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1909524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:7507112
Age: embryonic day 16.5
Note: Expression in wildtype not described.
Specimen Label: S2 E16.5 WT HTT
Specimen Num: 2
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Publication
31666698 | J:287495
First Author: Li Z
Year: 2019
Journal: Nature
Title: Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds.
Volume: 575
Issue: 7781
Pages: 203-209
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Publication
31263285 | J:340189
First Author: Zeitler B
Year: 2019
Journal: Nat Med
Title: Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease.
Volume: 25
Issue: 7
Pages: 1131-1142
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Publication
25574027 | J:220877
First Author: Biagioli M
Year: 2015
Journal: Hum Mol Genet
Title: Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation.
Volume: 24
Issue: 9
Pages: 2442-57
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Publication
23341618 | J:193824
First Author: Sathasivam K
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.
Volume: 110
Issue: 6
Pages: 2366-70
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Publication
38040383 | J:343745
 
First Author: Kuijper EC
Year: 2024
Journal: Neurobiol Dis
Title: Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice.
Volume: 190
Pages: 106368
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Publication
21636527 | J:174622
First Author: Huang K
Year: 2011
Journal: Hum Mol Genet
Title: Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
Volume: 20
Issue: 17
Pages: 3356-65
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Publication
38267530 | J:344956
First Author: Driscoll R
Year: 2024
Journal: Sci Rep
Title: Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice.
Volume: 14
Issue: 1
Pages: 2061
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Publication
25859666 | J:233517
First Author: Carty N
Year: 2015
Journal: PLoS One
Title: Characterization of HTT inclusion size, location, and timing in the zQ175 mouse model of Huntington's disease: an in vivo high-content imaging study.
Volume: 10
Issue: 4
Pages: e0123527
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Publication
37478856 | J:339121
First Author: Gander-Bui HTT
Year: 2023
Journal: Immunity
Title: Targeted removal of macrophage-secreted interleukin-1 receptor antagonist protects against lethal Candida albicans sepsis.
Volume: 56
Issue: 8
Pages: 1743-1760.e9
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Publication
29200404 | J:257519
First Author: Pham HTT
Year: 2018
Journal: J Clin Invest
Title: STAT5BN642H is a driver mutation for T cell neoplasia.
Volume: 128
Issue: 1
Pages: 387-401
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Publication
28211815 | J:325879
First Author: André EA
Year: 2017
Journal: J Huntingtons Dis
Title: Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.
Volume: 6
Issue: 1
Pages: 47-62
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Publication
34011527 | J:337398
First Author: Malaiya S
Year: 2021
Journal: J Neurosci
Title: Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations.
Volume: 41
Issue: 25
Pages: 5534-5552
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Publication
17147801 | J:117699
 
First Author: Van Raamsdonk JM
Year: 2006
Journal: BMC Neurosci
Title: Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.
Volume: 7
Pages: 80
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Publication
27623015 | J:260244
 
First Author: Arteaga-Bracho EE
Year: 2016
Journal: Neurobiol Dis
Title: Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease.
Volume: 96
Pages: 144-155
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Publication
10402204 | J:55405
First Author: Hodgson JG
Year: 1999
Journal: Neuron
Title: A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.
Volume: 23
Issue: 1
Pages: 181-92
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Publication
38374466 | J:346608
First Author: Bahat A
Year: 2024
Journal: EMBO Mol Med
Title: Lowering mutant huntingtin by small molecules relieves Huntington's disease symptoms and progression.
Volume: 16
Issue: 3
Pages: 523-546
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Publication
30282695 | J:266645
 
First Author: Southwell AL
Year: 2018
Journal: Sci Transl Med
Title: Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease.
Volume: 10
Issue: 461
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Publication
37894844 | J:342237
 
First Author: Merino M
Year: 2023
Journal: Int J Mol Sci
Title: Small Molecule Pytren-4QMn Metal Complex Slows down Huntington's Disease Progression in Male zQ175 Transgenic Mice.
Volume: 24
Issue: 20
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Publication
32581130 | J:291551
First Author: Sharma M
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease.
Volume: 117
Issue: 27
Pages: 15989-15999
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Publication
23925262 | J:217580
 
First Author: Oakeshott S
Year: 2012
Journal: PLoS Curr
Title: A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington's disease.
Volume: 4
Pages: e4f972cffe82c0
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Publication
30312396 | J:270016
First Author: Wood TE
Year: 2019
Journal: Hum Mol Genet
Title: Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington's disease mouse model.
Volume: 28
Issue: 3
Pages: 487-500
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Publication
11133364 | J:67366
First Author: Leavitt BR
Year: 2001
Journal: Am J Hum Genet
Title: Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo.
Volume: 68
Issue: 2
Pages: 313-24
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Publication
23001568 | J:191147
First Author: Southwell AL
Year: 2013
Journal: Hum Mol Genet
Title: A fully humanized transgenic mouse model of Huntington disease.
Volume: 22
Issue: 1
Pages: 18-34
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Publication
27334347 | J:257110
 
First Author: Soylu-Kucharz R
Year: 2016
Journal: Sci Rep
Title: Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the BACHD mouse model of Huntington's disease.
Volume: 6
Pages: 28322
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Publication
28391067 | J:244025
 
First Author: Silva FR
Year: 2017
Journal: Neurobiol Aging
Title: N-type Ca2+ channels are affected by full-length mutant huntingtin expression in a mouse model of Huntington's disease.
Volume: 55
Pages: 1-10
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Publication
30897080 | J:274023
First Author: Murthy V
Year: 2019
Journal: PLoS Genet
Title: Hypomorphic mutation of the mouse Huntington's disease gene orthologue.
Volume: 15
Issue: 3
Pages: e1007765
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Publication
24728353 | J:215223
First Author: Kolodziejczyk K
Year: 2014
Journal: PLoS One
Title: Striatal synaptic dysfunction and hippocampal plasticity deficits in the Hu97/18 mouse model of Huntington disease.
Volume: 9
Issue: 4
Pages: e94562
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Publication
27913616 | J:242623
First Author: Neto JL
Year: 2017
Journal: Genetics
Title: Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice.
Volume: 205
Issue: 2
Pages: 503-516
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Publication
24951540 | J:214977
First Author: Hyrskyluoto A
Year: 2014
Journal: Hum Mol Genet
Title: Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1α.
Volume: 23
Issue: 22
Pages: 5928-39
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Allele
Htt<tm1(HTT*)Chdi> | MGI:7576912
Name: huntingtin; targeted mutation 1, David Howland
Allele Type: Targeted
Attribute String: Humanized sequence
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Publication
25789755 | J:221608
First Author: Huang B
Year: 2015
Journal: Neuron
Title: Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes.
Volume: 85
Issue: 6
Pages: 1212-26
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Publication
30624705 | J:276444
First Author: Petkau TL
Year: 2019
Journal: Hum Mol Genet
Title: Mutant huntingtin expression in microglia is neither required nor sufficient to cause the Huntington's disease-like phenotype in BACHD mice.
Volume: 28
Issue: 10
Pages: 1661-1670
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Publication
23251447 | J:195543
First Author: Lundh SH
Year: 2012
Journal: PLoS One
Title: Expression of mutant huntingtin in leptin receptor-expressing neurons does not control the metabolic and psychiatric phenotype of the BACHD mouse.
Volume: 7
Issue: 12
Pages: e51168
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Publication
36776123 | J:338587
First Author: Bergh S
Year: 2023
Journal: Neuropathol Appl Neurobiol
Title: Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease.
Volume: 49
Issue: 2
Pages: e12891
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Publication
27008868 | J:236706
First Author: Chandra A
Year: 2016
Journal: Hum Mol Genet
Title: Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease.
Volume: 25
Issue: 11
Pages: 2269-2282
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Publication
30913220 | J:274737
First Author: Reindl W
Year: 2019
Journal: PLoS One
Title: Meso scale discovery-based assays for the detection of aggregated huntingtin.
Volume: 14
Issue: 3
Pages: e0213521
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Publication
34390831 | J:313598
 
First Author: Lemarié FL
Year: 2021
Journal: Neurobiol Dis
Title: Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity.
Volume: 158
Pages: 105479
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Publication
34504195 | J:313750
First Author: Herrmann F
Year: 2021
Journal: Sci Rep
Title: Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates.
Volume: 11
Issue: 1
Pages: 17977
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Publication
12926013 | J:85298
First Author: Menalled LB
Year: 2003
Journal: J Comp Neurol
Title: Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.
Volume: 465
Issue: 1
Pages: 11-26
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Publication
24376631 | J:211126
First Author: Baldo B
Year: 2013
Journal: PLoS One
Title: Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction.
Volume: 8
Issue: 12
Pages: e83050
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Publication
31816043 | J:288289
First Author: Zhu Y
Year: 2020
Journal: Hum Mol Genet
Title: Progressive cardiac arrhythmias and ECG abnormalities in the Huntington's disease BACHD mouse model.
Volume: 29
Issue: 3
Pages: 369-381
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Publication
30391555 | J:321899
 
First Author: Park H
Year: 2019
Journal: Neurosci Res
Title: Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice.
Volume: 147
Pages: 58-63
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Publication
35086928 | J:327019
 
First Author: Ramírez-Jarquín UN
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease.
Volume: 119
Issue: 5
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Publication
16777606 | J:120991
First Author: Graham RK
Year: 2006
Journal: Cell
Title: Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Volume: 125
Issue: 6
Pages: 1179-91
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Publication
32640230 | J:300081
First Author: Agasse F
Year: 2020
Journal: Cell Rep
Title: Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin.
Volume: 32
Issue: 1
Pages: 107865
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Publication
17055784 | J:129751
First Author: Weydt P
Year: 2006
Journal: Cell Metab
Title: Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.
Volume: 4
Issue: 5
Pages: 349-62
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Publication
29694882 | J:271139
First Author: Child DD
Year: 2018
Journal: Cell Rep
Title: Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington's Disease.
Volume: 23
Issue: 4
Pages: 1020-1033
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Publication
28628038 | J:244316
First Author: Yang S
Year: 2017
Journal: J Clin Invest
Title: CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease.
Volume: 127
Issue: 7
Pages: 2719-2724
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Publication
20739295 | J:165147
First Author: Marcora E
Year: 2010
Journal: Hum Mol Genet
Title: The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus.
Volume: 19
Issue: 22
Pages: 4373-84
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Publication
33335120 | J:341817
First Author: Fodale V
Year: 2020
Journal: Sci Rep
Title: Analysis of mutant and total huntingtin expression in Huntington's disease murine models.
Volume: 10
Issue: 1
Pages: 22137
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Publication
36640336 | J:333446
First Author: Gangwani MR
Year: 2023
Journal: Cell Rep
Title: Neuronal and astrocytic contributions to Huntington's disease dissected with zinc finger protein transcriptional repressors.
Volume: 42
Issue: 1
Pages: 111953
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Publication
28384479 | J:240166
First Author: Grima JC
Year: 2017
Journal: Neuron
Title: Mutant Huntingtin Disrupts the Nuclear Pore Complex.
Volume: 94
Issue: 1
Pages: 93-107.e6
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Publication
33441541 | J:300873
First Author: Alcalá-Vida R
Year: 2021
Journal: Nat Commun
Title: Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington's disease mice.
Volume: 12
Issue: 1
Pages: 364
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Publication
31968243 | J:288123
First Author: Burrus CJ
Year: 2020
Journal: Cell Rep
Title: Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival.
Volume: 30
Issue: 3
Pages: 642-657.e6
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Publication
36574405 | J:340441
First Author: Geijtenbeek KW
Year: 2022
Journal: PLoS One
Title: Reduction in PA28αβ activation in HD mouse brain correlates to increased mHTT aggregation in cell models.
Volume: 17
Issue: 12
Pages: e0278130
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Publication
18923047 | J:141086
First Author: Benn CL
Year: 2008
Journal: J Neurosci
Title: Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.
Volume: 28
Issue: 42
Pages: 10720-33
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Publication
22939619 | J:187977
First Author: Yu D
Year: 2012
Journal: Cell
Title: Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.
Volume: 150
Issue: 5
Pages: 895-908
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Publication
31666200 | J:298517
 
First Author: Sava V
Year: 2020
Journal: Nanomedicine
Title: Enriched chitosan nanoparticles loaded with siRNA are effective in lowering Huntington's disease gene expression following intranasal administration.
Volume: 24
Pages: 102119
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Publication
16076956 | J:100467
First Author: Slow EJ
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.
Volume: 102
Issue: 32
Pages: 11402-7
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Publication
15340079 | J:92971
First Author: Trushina E
Year: 2004
Journal: Mol Cell Biol
Title: Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.
Volume: 24
Issue: 18
Pages: 8195-209
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Publication
16183657 | J:102752
First Author: Benn CL
Year: 2005
Journal: Hum Mol Genet
Title: Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.
Volume: 14
Issue: 20
Pages: 3065-78
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Publication
19345187 | J:157425
First Author: Jeong H
Year: 2009
Journal: Cell
Title: Acetylation targets mutant huntingtin to autophagosomes for degradation.
Volume: 137
Issue: 1
Pages: 60-72
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Publication
22355657 | J:206119
 
First Author: Ma B
Year: 2011
Journal: Sci Rep
Title: Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons.
Volume: 1
Pages: 140
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Publication
24780625 | J:214667
First Author: Ismailoglu I
Year: 2014
Journal: Dev Biol
Title: Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells.
Volume: 391
Issue: 2
Pages: 230-40
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Publication
32444599 | J:292258
First Author: Yang H
Year: 2020
Journal: Nat Commun
Title: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form.
Volume: 11
Issue: 1
Pages: 2582
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Publication
9599014 | J:47245
First Author: Bertaux F
Year: 1998
Journal: FEBS Lett
Title: HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice.
Volume: 426
Issue: 2
Pages: 229-32
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Publication
18669659 | J:140052
First Author: Savas JN
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies.
Volume: 105
Issue: 31
Pages: 10820-5
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Publication
10899153 | J:63451
First Author: Schimenti JC
Year: 2000
Journal: Genome Res
Title: Interdigitated deletion complexes on mouse chromosome 5 induced by irradiation of embryonic stem cells.
Volume: 10
Issue: 7
Pages: 1043-50
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Author
Pham HTT
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Author
Nguyen HTT
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Author
Gander-Bui HTT
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Author
Nhu HTT
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Author
Ha HTT
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Publication
19036965 | J:142345
First Author: Cowan CM
Year: 2008
Journal: J Neurosci
Title: Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity.
Volume: 28
Issue: 48
Pages: 12725-35
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Publication
17947312 | J:144266
First Author: Milnerwood AJ
Year: 2007
Journal: J Physiol
Title: Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load.
Volume: 585
Issue: Pt 3
Pages: 817-31
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Publication
21536587 | J:173410
First Author: Jacobsen JC
Year: 2011
Journal: Hum Mol Genet
Title: HD CAG-correlated gene expression changes support a simple dominant gain of function.
Volume: 20
Issue: 14
Pages: 2846-60
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Publication
11709539 | J:72915
First Author: Auerbach W
Year: 2001
Journal: Hum Mol Genet
Title: The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin.
Volume: 10
Issue: 22
Pages: 2515-23
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Publication
36650127 | J:339512
First Author: Matsushima A
Year: 2023
Journal: Nat Commun
Title: Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington's disease.
Volume: 14
Issue: 1
Pages: 282
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Publication
9887339 | J:52440
First Author: Wheeler VC
Year: 1999
Journal: Hum Mol Genet
Title: Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse.
Volume: 8
Issue: 1
Pages: 115-22
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Publication
27995895 | J:239446
   
First Author: Atherton JF
Year: 2016
Journal: Elife
Title: Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease.
Volume: 5
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Publication
27140644 | J:232181
First Author: Molero AE
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease.
Volume: 113
Issue: 20
Pages: 5736-41
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Publication
25738228 | J:220707
   
First Author: Yao Y
Year: 2015
Journal: Elife
Title: A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.
Volume: 4
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Publication
15190011 | J:91795
First Author: Schilling G
Year: 2004
Journal: Hum Mol Genet
Title: Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice.
Volume: 13
Issue: 15
Pages: 1599-610
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Publication
24019939 | J:206407
First Author: Pla P
Year: 2013
Journal: PLoS One
Title: Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse.
Volume: 8
Issue: 9
Pages: e73902
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Publication
18558632 | J:138148
First Author: Wang CE
Year: 2008
Journal: Hum Mol Genet
Title: Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.
Volume: 17
Issue: 17
Pages: 2738-51
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Publication
27378694 | J:237863
First Author: Southwell AL
Year: 2016
Journal: Hum Mol Genet
Title: An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes.
Volume: 25
Issue: 17
Pages: 3654-3675
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