|  Help  |  About  |  Contact Us

Search our database by keyword

- or -

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 7 out of 7 for Hira

Category restricted to ProteinDomain (x)

0.017s

Categories

Category: ProteinDomain
Type Details Score
Protein Domain
Type: Domain
Description: The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain .
Protein Domain
Type: Conserved_site
Description: The HirA B (Histone regulatory homologue A binding) motif is the essential binding interface between and ASF1a, of approx. 40 residues. It forms an antiparallel β-hairpin that binds perpendicular to the strands of the β-sandwich of ASF1a N-terminal core domain, via β-sheet, salt bridge and van der Waals interactions []. The two histone chaperone proteins, HIRA and ASF1a, form a heterodimer with histones H3 and H4. HIRA is the human orthologue of Hir proteins known to silence histone gene expression and create transcriptionally silent heterochromatin in yeast, flies, plants and humans. The HIR complex is composed of HIR1, HIR2, HIR3 and HPC2, and interacts with ASF1. The HIR complex cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1.
Protein Domain
Type: Family
Description: HIRIP3 interacts with the HIRA histone chaperone []. It can be phosphorylated by the serine-threonine kinase CK2 and may be involved in chromatin metabolism [].
Protein Domain
Type: Family
Description: This entry represents ubinuclein-2 (UBN2). It contains a conserved HIRA-binding domain, which directly interacts with the N-terminal WD repeats of HIRA []. UBN2 and UBN1 are believed to be the orthologs of Hpc2p, a subunit of the HIR complex (a nucleosome assembly complex involved in regulation of histone gene transcription) in budding yeast []. It is phosphorylated upon DNA damage, probably by ATM or ATR [].
Protein Domain
Type: Family
Description: Ubinuclein-1 (UBN1) is part of the histone chaperone complex HIRA/UBN1/CABIN1/ASF1a that preferentially deposits the histone variant H3.3 into chromatin and is implicated in diverse chromatin regulatory events from gene activation to heterochromatinisation [, ].Ubinuclein-1 interacts with HIRA and is involved in the formation of senescence-associated heterochromatin foci (SAHF). SAHF are domains of specialised chromatin found in senescent cells that repress expression of proliferation-promoting genes [].
Protein Domain
Type: Family
Description: This entry includes NFU1-like proteins from eukaryotes and some uncharacterised proteins from prokaryotes.Nfu functions as a scaffold protein for assembly and delivery of rudimentary Fe-S clusters to target proteins [, ]. A human Nfu homologue, HIRA-interacting protein 5 (HIRIP5), was first identified in a two-hybrid screen for proteins that interact with the transcription regulator HIRA []. It seems that two human Nfu isoforms are generated by alternative explicing, which are subsequently targeted to different subcellular compartments [].
Protein Domain
Type: Family
Description: This entry includes HIR1/HIR2 from yeasts and HIRA from animals. They are WD-repeat containing proteins required for regulation of histone gene transcription. The budding yeast HIR complex is composed of Hir1, Hir2, Hir3 and Hpc2, and interacts with ASF1 [, ]. The HIR complex cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1 [].