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Search results 1 to 100 out of 223 for Ifih1

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
64135 | IFIH1
Type: gene
Organism: human
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Gene
459692 | IFIH1
Type: gene
Organism: chimpanzee
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Gene
535490 | IFIH1
Type: gene
Organism: cattle
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Gene
424185 | IFIH1
Type: gene
Organism: chicken
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Gene
565759 | ifih1
Type: gene
Organism: zebrafish
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Gene
702024 | IFIH1
Type: gene
Organism: macaque, rhesus
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Gene
100488298 | ifih1
Type: gene
Organism: frog, western clawed
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Gene
499801 | Ifih1
Type: gene
Organism: rat
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Gene
488371 | IFIH1
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1918836 | Ifih1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24995871 | J:230149
First Author: Oda H
Year: 2014
Journal: Am J Hum Genet
Title: Aicardi-Goutières syndrome is caused by IFIH1 mutations.
Volume: 95
Issue: 1
Pages: 121-5
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Publication
25591872 | J:246937
First Author: Lincez PJ
Year: 2015
Journal: Diabetes
Title: Reduced expression of the MDA5 Gene IFIH1 prevents autoimmune diabetes.
Volume: 64
Issue: 6
Pages: 2184-93
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Publication
22205024 | J:180757
First Author: Crampton SP
Year: 2012
Journal: J Immunol
Title: Ifih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance, and accelerated autoimmunity.
Volume: 188
Issue: 3
Pages: 1451-9
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Publication
28553952 | J:257959
First Author: Gorman JA
Year: 2017
Journal: Nat Immunol
Title: The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.
Volume: 18
Issue: 7
Pages: 744-752
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Publication
28851763 | J:249050
First Author: Dou Y
Year: 2017
Journal: EMBO J
Title: The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation.
Volume: 36
Issue: 18
Pages: 2742-2757
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Publication
36512407 | J:339647
 
First Author: Blum SI
Year: 2023
Journal: JCI Insight
Title: MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance.
Volume: 8
Issue: 2
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Publication
35168003 | J:324284
 
First Author: Ohto T
Year: 2022
Journal: J Autoimmun
Title: Intracellular virus sensor MDA5 mutation develops autoimmune myocarditis and nephritis.
Volume: 127
Pages: 102794
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Publication
31366715 | J:278687
First Author: Soda N
Year: 2019
Journal: J Immunol
Title: Singleton-Merten Syndrome-like Skeletal Abnormalities in Mice with Constitutively Activated MDA5.
Volume: 203
Issue: 5
Pages: 1356-1368
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Publication
16625202 | J:137522
First Author: Kato H
Year: 2006
Journal: Nature
Title: Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Volume: 441
Issue: 7089
Pages: 101-5
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Publication
31956894 | J:292357
First Author: Bajad P
Year: 2020
Journal: Nucleic Acids Res
Title: An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype.
Volume: 48
Issue: 6
Pages: 3286-3303
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Publication
33165593 | J:300370
     
First Author: Onizawa H
Year: 2020
Journal: Int Immunol
Title: Aicardi-Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5.
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Publication
28874170 | J:317546
First Author: Heraud-Farlow JE
Year: 2017
Journal: Genome Biol
Title: Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.
Volume: 18
Issue: 1
Pages: 166
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Protein Coding Gene
MGP_CAROLIEiJ_G0023594 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025772 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025748 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025743 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0025504 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1918836 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026190 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024968 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025484 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025615 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0025703 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0025608 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026247 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0024709 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025036 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025045 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0024516 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
12015121 | J:76465
First Author: Kovacsovics M
Year: 2002
Journal: Curr Biol
Title: Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation.
Volume: 12
Issue: 10
Pages: 838-43
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Publication
21217758 | J:168254
First Author: Züst R
Year: 2011
Journal: Nat Immunol
Title: Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.
Volume: 12
Issue: 2
Pages: 137-43
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Publication
22090123 | J:179386
First Author: Jin YH
Year: 2012
Journal: J Virol
Title: Melanoma differentiation-associated gene 5 is critical for protection against Theiler's virus-induced demyelinating disease.
Volume: 86
Issue: 3
Pages: 1531-43
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Publication
20107606 | J:162177
First Author: Gitlin L
Year: 2010
Journal: PLoS Pathog
Title: Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo.
Volume: 6
Issue: 1
Pages: e1000734
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Publication
26423942 | J:227926
First Author: Zalinger ZB
Year: 2015
Journal: J Virol
Title: MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus.
Volume: 89
Issue: 24
Pages: 12330-40
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Publication
18941247 | J:140714
First Author: Tamassia N
Year: 2008
Journal: J Immunol
Title: Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils.
Volume: 181
Issue: 9
Pages: 6563-73
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Publication
33767151 | J:340261
First Author: Brown MC
Year: 2021
Journal: Nat Commun
Title: Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling.
Volume: 12
Issue: 1
Pages: 1858
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Publication
36122455 | J:329992
 
First Author: Lee S
Year: 2022
Journal: Biochem Biophys Res Commun
Title: Attenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model.
Volume: 629
Pages: 171-175
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Publication
23328395 | J:193402
First Author: Motz C
Year: 2013
Journal: Science
Title: Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling.
Volume: 339
Issue: 6120
Pages: 690-3
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Publication
19036857 | J:147226
First Author: De Miranda J
Year: 2009
Journal: FASEB J
Title: Astrocytes recognize intracellular polyinosinic-polycytidylic acid via MDA-5.
Volume: 23
Issue: 4
Pages: 1064-71
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Publication
23090998 | J:191237
First Author: Berke IC
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: MDA5 assembles into a polar helical filament on dsRNA.
Volume: 109
Issue: 45
Pages: 18437-41
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Publication
24474800 | J:206642
First Author: Wu J
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality.
Volume: 111
Issue: 4
Pages: E511-20
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Publication
34482560 | J:335378
First Author: Zhang X
Year: 2022
Journal: Hepatology
Title: Melanoma differentiation-Associated gene 5 protects against NASH in mice.
Volume: 75
Issue: 4
Pages: 924-938
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689417
Stage: TS17
Assay Id: MGI:7565762
Age: embryonic day 10.5
Specimen Label: E10.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:7565762
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:7565762
Age: postnatal newborn
Specimen Label: Neonatal
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565762
Age: postnatal week 2
Specimen Label: Week 2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565762
Age: postnatal week 10
Specimen Label: Week 10
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:7565767
Age: postnatal newborn
Specimen Label: Neonatal
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565767
Age: postnatal week 1
Specimen Label: wk 1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565767
Age: postnatal week 2
Specimen Label: wk 2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565767
Age: postnatal week 3
Specimen Label: wk 3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565767
Age: postnatal week 4
Specimen Label: wk 4
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:7565718
Assay Type: RT-PCR
Annotation Date: 2023-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7565767
Age: postnatal week 5
Specimen Label: wk 5
Detected: true
Specimen Num: 6
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Publication
- | J:77433
   
First Author: Kang DC
Year: 2002
Journal: GenBank Submission
Title: Mus musculus strain C57BL/6J melanoma differentiation associated gene 5-like protein mRNA, complete cds
Pages: AF374384
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Publication
- | J:74829
   
First Author: Strausberg R
Year: 2002
Journal: GenBank Submission
Title: Mus musculus, simialr to RIKEN cDNA 9130009C22 gene, clone IMAGE: 3990931, mRNA, partial cds
Pages: BC019605
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Publication
21187438 | J:168914
First Author: Broquet AH
Year: 2011
Journal: J Immunol
Title: RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium.
Volume: 186
Issue: 3
Pages: 1618-26
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Publication
28031478 | J:240099
First Author: Lang X
Year: 2017
Journal: J Exp Med
Title: TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.
Volume: 214
Issue: 2
Pages: 459-473
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Publication
28848065 | J:254366
First Author: Kasumba DM
Year: 2017
Journal: J Immunol
Title: A Plant-Derived Nucleic Acid Reconciles Type I IFN and a Pyroptotic-like Event in Immunity against Respiratory Viruses.
Volume: 199
Issue: 7
Pages: 2460-2474
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Publication
28250012 | J:241587
First Author: Hu MM
Year: 2017
Journal: J Exp Med
Title: Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.
Volume: 214
Issue: 4
Pages: 973-989
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Publication
23966390 | J:310254
First Author: Lazear HM
Year: 2013
Journal: J Virol
Title: Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the central nervous system.
Volume: 87
Issue: 21
Pages: 11401-15
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Publication
25451939 | J:218760
First Author: Kitai Y
Year: 2015
Journal: J Biol Chem
Title: Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B.
Volume: 290
Issue: 2
Pages: 1269-80
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Publication
22314235 | J:182522
First Author: Berke IC
Year: 2012
Journal: EMBO J
Title: MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA.
Volume: 31
Issue: 7
Pages: 1714-26
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Publication
30361393 | J:269483
 
First Author: Nakahama T
Year: 2018
Journal: EMBO Rep
Title: ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity.
Volume: 19
Issue: 12
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Publication
29723194 | J:262046
First Author: Harris ML
Year: 2018
Journal: PLoS Biol
Title: A direct link between MITF, innate immunity, and hair graying.
Volume: 16
Issue: 5
Pages: e2003648
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Publication
38128529 | J:344303
First Author: Knebel UE
Year: 2024
Journal: Cell Metab
Title: Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes.
Volume: 36
Issue: 1
Pages: 48-61.e6
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Publication
34969816 | J:320956
 
First Author: Guo X
Year: 2022
Journal: Life Sci Alliance
Title: ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway.
Volume: 5
Issue: 3
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Publication
36975179 | J:338600
First Author: Liang Z
Year: 2023
Journal: EMBO Rep
Title: The phenotype of the most common human ADAR1p150 Zα mutation P193A in mice is partially penetrant.
Volume: 24
Issue: 5
Pages: e55835
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Publication
32396862 | J:328612
First Author: Guallar D
Year: 2020
Journal: Cell Stem Cell
Title: ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress.
Volume: 27
Issue: 2
Pages: 300-314.e11
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Publication
32251420 | J:292942
First Author: Zhong X
Year: 2020
Journal: PLoS Pathog
Title: ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response.
Volume: 16
Issue: 4
Pages: e1008457
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Publication
23926323 | J:205789
First Author: Lu HL
Year: 2013
Journal: J Immunol
Title: Melanoma differentiation-associated gene 5 senses hepatitis B virus and activates innate immune signaling to suppress virus replication.
Volume: 191
Issue: 6
Pages: 3264-76
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Publication
18591409 | J:137451
First Author: Kato H
Year: 2008
Journal: J Exp Med
Title: Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.
Volume: 205
Issue: 7
Pages: 1601-10
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Publication
26275108 | J:226177
First Author: Liddicoat BJ
Year: 2015
Journal: Science
Title: RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.
Volume: 349
Issue: 6252
Pages: 1115-20
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Publication
34772697 | J:317182
     
First Author: Inoue M
Year: 2021
Journal: J Immunol
Title: An Aicardi-Goutières Syndrome-Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice.
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Publication
34525338 | J:323650
First Author: Nakahama T
Year: 2021
Journal: Immunity
Title: Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy.
Volume: 54
Issue: 9
Pages: 1976-1988.e7
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Publication
20164430 | J:160108
First Author: Wang Y
Year: 2010
Journal: J Immunol
Title: Cutting edge: polyinosinic:polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells.
Volume: 184
Issue: 6
Pages: 2751-5
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Publication
18636103 | J:162720
First Author: McCartney SA
Year: 2008
Journal: PLoS Pathog
Title: MDA-5 recognition of a murine norovirus.
Volume: 4
Issue: 7
Pages: e1000108
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Publication
21637773 | J:176090
First Author: Wang Q
Year: 2011
Journal: PLoS Pathog
Title: MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness.
Volume: 7
Issue: 5
Pages: e1002070
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Publication
21242525 | J:169151
First Author: Jelinek I
Year: 2011
Journal: J Immunol
Title: TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection.
Volume: 186
Issue: 4
Pages: 2422-9
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Publication
23499489 | J:195116
First Author: Wies E
Year: 2013
Journal: Immunity
Title: Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.
Volume: 38
Issue: 3
Pages: 437-49
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Publication
28484023 | J:242293
First Author: Deng X
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages.
Volume: 114
Issue: 21
Pages: E4251-E4260
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Publication
31067281 | J:275459
First Author: Veazey JM
Year: 2019
Journal: PLoS One
Title: Distinct roles for MDA5 and TLR3 in the acute response to inhaled double-stranded RNA.
Volume: 14
Issue: 5
Pages: e0216056
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Publication
19850889 | J:154665
First Author: Flür K
Year: 2009
Journal: Am J Pathol
Title: Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: Implications for viral infection-associated glomerulonephritis.
Volume: 175
Issue: 5
Pages: 2014-22
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Publication
25119032 | J:217083
First Author: Goubau D
Year: 2014
Journal: Nature
Title: Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.
Volume: 514
Issue: 7522
Pages: 372-375
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Publication
25012502 | J:230138
First Author: Duewell P
Year: 2014
Journal: Cell Death Differ
Title: RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells.
Volume: 21
Issue: 12
Pages: 1825-37
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Publication
17942531 | J:183219
First Author: Loo YM
Year: 2008
Journal: J Virol
Title: Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Volume: 82
Issue: 1
Pages: 335-45
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Publication
20080593 | J:156867
First Author: Satoh T
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
Volume: 107
Issue: 4
Pages: 1512-7
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Publication
29117565 | J:255265
First Author: Zhao C
Year: 2017
Journal: Cell Rep
Title: The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I.
Volume: 21
Issue: 6
Pages: 1613-1623
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Publication
33087405 | J:300722
First Author: Wang X
Year: 2020
Journal: J Immunol
Title: MDA5 Is an Essential Sensor of a Pathogen-Associated Molecular Pattern Associated with Vitality That Is Necessary for Host Resistance against Aspergillus fumigatus.
Volume: 205
Issue: 11
Pages: 3058-3070
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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