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Search results 201 to 266 out of 266 for Coq7

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Type Details Score
Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Gene
492506 | pptc7a
Type: gene
Organism: zebrafish
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Gene
562909 | pptc7b
Type: gene
Organism: zebrafish
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Publication
9823893 | -
First Author: Andersson SG
Year: 1998
Journal: Nature
Title: The genome sequence of Rickettsia prowazekii and the origin of mitochondria.
Volume: 396
Issue: 6707
Pages: 133-40
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Publication
20923139 | -
First Author: Behan RK
Year: 2010
Journal: Biochemistry
Title: The aging-associated enzyme CLK-1 is a member of the carboxylate-bridged diiron family of proteins.
Volume: 49
Issue: 45
Pages: 9679-81
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Protein Domain
IPR011566 | Ubq_synth_Coq7
Type: Family
Description: Coq7 (also known as Clk-1 and CAT5) is a di-iron carboxylate protein occuring in both prokaryotes and eukaryotes that is essential for ubiquinone biosynthesis [, ]. It has been implicated in the aging process as mutations in the Caenorhabditis elegans gene lead to increased lifespan []. Coq7 is a membrane-bound protein that functions as a monooxygenase to hydroxylate demethoxyubiquinone (DMQ or 2-methoxy-5-methyl-6-polyprenyl-1,4-benzoquinone) in the penultimate step of ubiquinone biosynthesis []. Biochemical studies indicate that NADH can serve directly as a reductant for catalytic activation of dioxygen and substrate oxidation by the enzyme, with no requirement for an additional reductase protein component []. This direct reaction with NADH is so far unique amongst members of the di-iron carboxylate protein family.
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Publication
30564271 | J:285575
 
First Author: Zhou D
Year: 2018
Journal: Front Genet
Title: Ethanol's Effect on Coq7 Expression in the Hippocampus of Mice.
Volume: 9
Pages: 602
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DO Term
DOID:0070245 | primary coenzyme Q10 deficiency 8
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DO Term
DOID:0081428 | autosomal recessive distal hereditary motor neuronopathy 9
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Protein Domain
IPR027540 | Coq4_euk
Type: Family
Description: Ubiquinone biosynthesis protein Coq4 is a component of a multi-subunit COQ enzyme complex (composed of at least Coq3, Coq4, Coq5, Coq6, Coq7 and Coq9), which plays a role in the coenzyme Q (ubiquinone) biosynthetic pathway [, , ]. Coq4 plays an essential role in organising the COQ enzyme complex and is required for steady-state levels of Coq3, Coq6, Coq7 and Coq9 []. This entry represents eukaryotic Coq4.
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Protein
Q8BGB8
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
B9EID1
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
B7ZCV4
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
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Protein
Q8BLS2
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Publication
11469793 | -
First Author: Belogrudov GI
Year: 2001
Journal: Arch Biochem Biophys
Title: Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis.
Volume: 392
Issue: 1
Pages: 48-58
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Publication
15792955 | -
First Author: Marbois B
Year: 2005
Journal: J Biol Chem
Title: Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.
Volume: 280
Issue: 21
Pages: 20231-8
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Publication
17391640 | -
First Author: Hsieh EJ
Year: 2007
Journal: Arch Biochem Biophys
Title: Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex.
Volume: 463
Issue: 1
Pages: 19-26
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Publication
19022396 | -
First Author: Marbois B
Year: 2009
Journal: Biochim Biophys Acta
Title: The yeast Coq4 polypeptide organizes a mitochondrial protein complex essential for coenzyme Q biosynthesis.
Volume: 1791
Issue: 1
Pages: 69-75
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Protein
D6RJJ8
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
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Protein
Q8CHS5
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Protein Domain
IPR007715 | Coq4
Type: Family
Description: Coq4 is a component of a multi-subunit COQ enzyme complex, which plays a role in the coenzyme Q (ubiquinone) biosynthetic pathway [, , ]. In budding yeasts, Coq4 plays an essential role in organising the COQ enzyme complex and is required for steady-state levels of Coq3, Coq6, Coq7 and Coq9 [].
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Publication
30228311 | J:288751
First Author: Rodríguez-Hidalgo M
Year: 2018
Journal: Sci Rep
Title: Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.
Volume: 8
Issue: 1
Pages: 14013
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Protein Domain
IPR010971 | UbiH/COQ6
Type: Family
Description: This entry represents a family of FAD-dependent hydroxylases (monooxygenases), which are all believed to act in the aerobic ubiquinone biosynthesis pathway []. In Escherichia coli, three enzyme activities have been described: UbiI, UbiH and UbiF []. UbiH and UbiF are similar to one another and form the basis of this subfamily. UbiI (also known as visC) []is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (also known as visB) []. Several other species appear to have three homologues in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homologue in this subfamily (COQ6, []) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF.
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Publication
23255162 | J:193288
First Author: García-Corzo L
Year: 2013
Journal: Hum Mol Genet
Title: Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency.
Volume: 22
Issue: 6
Pages: 1233-48
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Publication
12721307 | -
First Author: Gin P
Year: 2003
Journal: J Biol Chem
Title: The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis.
Volume: 278
Issue: 28
Pages: 25308-16
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Publication
1339425 | -
First Author: Nakahigashi K
Year: 1992
Journal: J Bacteriol
Title: Isolation and characterization of a light-sensitive mutant of Escherichia coli K-12 with a mutation in a gene that is required for the biosynthesis of ubiquinone.
Volume: 174
Issue: 22
Pages: 7352-9
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Publication
365223 | -
First Author: Alexander K
Year: 1978
Journal: Biochemistry
Title: Alternative hydroxylases for the aerobic and anaerobic biosynthesis of ubiquinone in Escherichia coli.
Volume: 17
Issue: 22
Pages: 4750-5
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Publication
10802164 | -
First Author: Kwon O
Year: 2000
Journal: FEMS Microbiol Lett
Title: Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene.
Volume: 186
Issue: 2
Pages: 157-61
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Protein Domain
IPR018168 | Ubi_Hdrlase_CS
Type: Conserved_site
Description: This entry represents FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway []. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions []. In Escherichia coli, three enzyme activities have been described: UbiB (which acts first at position 6, see ), UbiH (which acts at position 4, []) and UbiF (which acts at position 5, []). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB) []. Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homologue in this subfamily (COQ6, []) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF.This entry represents the conserved site of the ubiquinone biosynthesis hydroxylase enzyme.
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Publication
23709220 | -
First Author: Hajj Chehade M
Year: 2013
Journal: J Biol Chem
Title: ubiI, a new gene in Escherichia coli coenzyme Q biosynthesis, is involved in aerobic C5-hydroxylation.
Volume: 288
Issue: 27
Pages: 20085-92
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Protein
D6RG57
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: false
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Publication
11153266 | -
 
First Author: Meganathan R
Year: 2001
Journal: Vitam Horm
Title: Biosynthesis of menaquinone (vitamin K2) and ubiquinone (coenzyme Q): a perspective on enzymatic mechanisms.
Volume: 61
Pages: 173-218
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Protein
Q8R1S0
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
D3YW66
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Publication
11583838 | -
First Author: Meganathan R
Year: 2001
Journal: FEMS Microbiol Lett
Title: Ubiquinone biosynthesis in microorganisms.
Volume: 203
Issue: 2
Pages: 131-9
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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