| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:5001718 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:2760523 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:5542272 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:8682 |
|
| Specimen Label: |
GUDMAP:8682 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5001718 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:2852723 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:5542272 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:8508 |
|
| Specimen Label: |
GUDMAP:8508 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5001718 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Absent |
| Sex: |
Female |
| Emaps: |
EMAPS:2852723 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:5542272 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:8682 |
|
| Specimen Label: |
GUDMAP:8682 |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5001718 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Absent |
| Sex: |
Female |
| Emaps: |
EMAPS:2874723 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:5542272 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:8682 |
|
| Specimen Label: |
GUDMAP:8682 |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6457497 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2020-12-22 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:6488118 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
S1 Table A25 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5001718 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:2850023 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:5542272 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:8508 |
|
| Specimen Label: |
GUDMAP:8508 |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5001718 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Absent |
| Sex: |
Female |
| Emaps: |
EMAPS:2850023 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:5542272 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:8682 |
|
| Specimen Label: |
GUDMAP:8682 |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6181674 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689419 |
| Pattern: |
Not Specified |
| Stage: |
TS19 |
| Assay Id: |
MGI:6191173 |
| Age: |
embryonic day 11.5 |
|
|
| Specimen Label: |
Table S2 - E11.5 - Pvrl2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6181674 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689421 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:6191173 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
Table S2 - E13.5 - Pvrl2 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6181674 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1689424 |
|
| Stage: |
TS24 |
| Assay Id: |
MGI:6191173 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
Table S2 - E15.5 - Pvrl2 |
| Detected: |
false |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6181674 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689426 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:6191173 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
Table S2 - E18.5 - Pvrl2 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6181674 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6191173 |
| Age: |
postnatal day 4 |
|
|
| Specimen Label: |
Table S2 - P4 - Pvrl2 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6181674 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6191173 |
| Age: |
postnatal day 14 |
|
|
| Specimen Label: |
Table S2 - P14 - Pvrl2 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6181674 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6191173 |
| Age: |
postnatal day 28 |
|
|
| Specimen Label: |
Table S2 - P28 - Pvrl2 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5001718 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Absent |
| Sex: |
Female |
| Emaps: |
EMAPS:1796223 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:5542272 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:8682 |
|
| Specimen Label: |
GUDMAP:8682 |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5571573 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-07-09 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3808527 |
| Pattern: |
Regionally restricted |
| Stage: |
TS27 |
| Assay Id: |
MGI:5571734 |
| Age: |
postnatal day 0 |
| Image: |
8C |
| Note: |
Expression is in ameloblasts. |
| Specimen Label: |
8C |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5571573 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-07-09 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3808528 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:5571734 |
| Age: |
postnatal day 10 |
| Image: |
8E |
| Note: |
Expression is in ameloblasts. |
| Specimen Label: |
8E |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5571573 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-07-09 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3808124 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:5571734 |
| Age: |
embryonic day 16.5 |
|
|
| Specimen Label: |
not shown E16 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Seth S |
| Year: |
2009 |
| Journal: |
Eur J Immunol |
| Title: |
Abundance of follicular helper T cells in Peyer's patches is modulated by CD155. |
| Volume: |
39 |
| Issue: |
11 |
| Pages: |
3160-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nagumo Y |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice. |
| Volume: |
9 |
| Issue: |
11 |
| Pages: |
e112415 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Murter B |
| Year: |
2019 |
| Journal: |
Cancer Immunol Res |
| Title: |
Mouse PVRIG Has CD8+ T Cell-Specific Coinhibitory Functions and Dampens Antitumor Immunity. |
| Volume: |
7 |
| Issue: |
2 |
| Pages: |
244-256 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ozaki-Kuroda K |
| Year: |
2002 |
| Journal: |
Curr Biol |
| Title: |
Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions. |
| Volume: |
12 |
| Issue: |
13 |
| Pages: |
1145-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tahara-Hanaoka S |
| Year: |
2005 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands. |
| Volume: |
329 |
| Issue: |
3 |
| Pages: |
996-1000 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takahashi K |
| Year: |
1999 |
| Journal: |
J Cell Biol |
| Title: |
Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein. |
| Volume: |
145 |
| Issue: |
3 |
| Pages: |
539-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kraus AK |
| Year: |
2016 |
| Journal: |
PLoS One |
| Title: |
The Role of T Cell Costimulation via DNAM-1 in Kidney Transplantation. |
| Volume: |
11 |
| Issue: |
2 |
| Pages: |
e0147951 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawagishi R |
| Year: |
2005 |
| Journal: |
Eur J Obstet Gynecol Reprod Biol |
| Title: |
Expression of nectin-2 in mouse granulosa cells. |
| Volume: |
121 |
| Issue: |
1 |
| Pages: |
71-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tahara-Hanaoka S |
| Year: |
2006 |
| Journal: |
Blood |
| Title: |
Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor. |
| Volume: |
107 |
| Issue: |
4 |
| Pages: |
1491-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanaka-Okamoto M |
| Year: |
2011 |
| Journal: |
J Cell Sci |
| Title: |
Involvement of afadin in barrier function and homeostasis of mouse intestinal epithelia. |
| Volume: |
124 |
| Issue: |
Pt 13 |
| Pages: |
2231-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mueller S |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains. |
| Volume: |
278 |
| Issue: |
33 |
| Pages: |
31251-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Satoh-Horikawa K |
| Year: |
2000 |
| Journal: |
J Biol Chem |
| Title: |
Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. |
| Volume: |
275 |
| Issue: |
14 |
| Pages: |
10291-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bosserhoff AK |
| Year: |
1997 |
| Journal: |
Dev Dyn |
| Title: |
Mouse CD-RAP/MIA gene: structure, chromosomal localization, and expression in cartilage and chondrosarcoma. |
| Volume: |
208 |
| Issue: |
4 |
| Pages: |
516-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Terada K |
| Year: |
2005 |
| Journal: |
EMBO J |
| Title: |
A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis. |
| Volume: |
24 |
| Issue: |
3 |
| Pages: |
611-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rossignoli A |
| Year: |
2017 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration. |
| Volume: |
37 |
| Issue: |
3 |
| Pages: |
534-542 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen S |
| Year: |
1997 |
| Journal: |
Neuron |
| Title: |
Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. |
| Volume: |
19 |
| Issue: |
5 |
| Pages: |
1017-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kobayashi R |
| Year: |
2014 |
| Journal: |
Genes Cells |
| Title: |
s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin. |
| Volume: |
19 |
| Issue: |
12 |
| Pages: |
853-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shingai T |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. |
| Volume: |
278 |
| Issue: |
37 |
| Pages: |
35421-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smith LE |
| Year: |
2016 |
| Journal: |
J Leukoc Biol |
| Title: |
Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions. |
| Volume: |
100 |
| Issue: |
4 |
| Pages: |
781-789 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gopalan G |
| Year: |
1999 |
| Journal: |
Mol Reprod Dev |
| Title: |
Novel mammalian kinase related to yeast and fly chromosome segregation regulators is exclusively expressed in the germline. |
| Volume: |
52 |
| Issue: |
1 |
| Pages: |
18-28 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Togashi H |
| Year: |
2011 |
| Journal: |
Science |
| Title: |
Nectins establish a checkerboard-like cellular pattern in the auditory epithelium. |
| Volume: |
333 |
| Issue: |
6046 |
| Pages: |
1144-7 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Okabe N |
| Year: |
2004 |
| Journal: |
Dev Dyn |
| Title: |
Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo. |
| Volume: |
230 |
| Issue: |
1 |
| Pages: |
174-86 |
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•
•
•
•
|
| Publication |
| First Author: |
Brakeman PR |
| Year: |
2009 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis. |
| Volume: |
296 |
| Issue: |
3 |
| Pages: |
F564-74 |
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•
•
•
•
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| Publication |
| First Author: |
Mora JM |
| Year: |
2012 |
| Journal: |
Biol Reprod |
| Title: |
Characterization and significance of adhesion and junction-related proteins in mouse ovarian follicles. |
| Volume: |
86 |
| Issue: |
5 |
| Pages: |
153, 1-14 |
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•
•
•
•
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| Publication |
| First Author: |
Inagaki M |
| Year: |
2005 |
| Journal: |
Development |
| Title: |
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. |
| Volume: |
132 |
| Issue: |
7 |
| Pages: |
1525-37 |
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•
•
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| Publication |
| First Author: |
Mollo MR |
| Year: |
2015 |
| Journal: |
Exp Dermatol |
| Title: |
p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis. |
| Volume: |
24 |
| Issue: |
2 |
| Pages: |
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•
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•
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| First Author: |
Takekuni K |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. |
| Volume: |
278 |
| Issue: |
8 |
| Pages: |
5497-500 |
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•
•
•
•
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| Publication |
| First Author: |
Ishiuchi T |
| Year: |
2012 |
| Journal: |
Genes Cells |
| Title: |
Nectins localize Willin to cell-cell junctions. |
| Volume: |
17 |
| Issue: |
5 |
| Pages: |
387-97 |
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•
•
•
•
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| Publication |
| First Author: |
Katsunuma S |
| Year: |
2016 |
| Journal: |
J Cell Biol |
| Title: |
Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium. |
| Volume: |
212 |
| Issue: |
5 |
| Pages: |
561-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoshida T |
| Year: |
2010 |
| Journal: |
Dev Dyn |
| Title: |
Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth. |
| Volume: |
239 |
| Issue: |
10 |
| Pages: |
2558-69 |
|
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•
•
•
•
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| Publication |
| First Author: |
Okabe N |
| Year: |
2004 |
| Journal: |
Dev Biol |
| Title: |
Contacts between the commissural axons and the floor plate cells are mediated by nectins. |
| Volume: |
273 |
| Issue: |
2 |
| Pages: |
244-56 |
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•
•
•
•
|
| Publication |
| First Author: |
Downes GB |
| Year: |
1999 |
| Journal: |
Genomics |
| Title: |
Chromosomal mapping of five mouse G protein gamma subunits. |
| Volume: |
57 |
| Issue: |
1 |
| Pages: |
173-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fukuda T |
| Year: |
2014 |
| Journal: |
Development |
| Title: |
Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities. |
| Volume: |
141 |
| Issue: |
2 |
| Pages: |
399-409 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang Z |
| Year: |
2013 |
| Journal: |
Development |
| Title: |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
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•
|
| Allele |
| Name: |
nectin cell adhesion molecule 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
nectin cell adhesion molecule 2; targeted mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Targeted |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
234
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Transmembrane protein PVRIG, also known as CD112 receptor (CD112R), is the cell surface receptor for NECTIN2 (CD antigen CD112). CD112R functions as a coinhibitory receptor for T cells, competing with CD226 to bind to CD112 []. |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stanietsky N |
| Year: |
2013 |
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Eur J Immunol |
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Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR. |
| Volume: |
43 |
| Issue: |
8 |
| Pages: |
2138-50 |
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•
•
•
•
•
|