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Search results 601 to 700 out of 748 for Ep300

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Type Details Score
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Diez E
Year: 2011
Journal: Genes Immun
Title: Identification and characterization of Cri1, a locus controlling mortality during Citrobacter rodentium infection in mice.
Volume: 12
Issue: 4
Pages: 280-90
Publication
First Author: Carim L
Year: 2000
Journal: Cytogenet Cell Genet
Title: Identification and expression analysis of C15orf3, a novel gene on chromosome 15q21.1-->q21.2.
Volume: 88
Issue: 3-4
Pages: 330-2
Publication
First Author: Lizcano F
Year: 2010
Journal: Biochem Biophys Res Commun
Title: EID1-induces brown-like adipocyte traits in white 3T3-L1 pre-adipocytes.
Volume: 398
Issue: 2
Pages: 160-5
Publication  
First Author: Fu X
Year: 2019
Journal: Gene
Title: Transcriptome profiling in Eid1-KO mice brain shows that Eid1 links cell proliferation in the brain.
Volume: 717
Pages: 143998
GXD Expression      
Probe: MGI:2681328
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2681335
Age: postnatal
Specimen Label: Kidney
Detected: true
Specimen Num: 7
GXD Expression        
Probe: MGI:2681327
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2681336
Age: postnatal
Specimen Label: Kidney
Specimen Num: 7
GXD Expression      
Probe: MGI:2681328
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:2681335
Age: postnatal
Specimen Label: Placenta
Detected: false
Specimen Num: 3
GXD Expression        
Probe: MGI:2681327
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:2681336
Age: postnatal
Specimen Label: Placenta
Specimen Num: 3
GXD Expression        
Probe: MGI:2681328
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2681335
Age: postnatal
Specimen Label: Lung
Specimen Num: 4
GXD Expression        
Probe: MGI:2681327
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2681336
Age: postnatal
Specimen Label: Lung
Specimen Num: 4
GXD Expression        
Probe: MGI:2681328
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2681335
Age: postnatal
Specimen Label: Skeletal
Specimen Num: 6
GXD Expression        
Probe: MGI:2681327
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2681336
Age: postnatal
Specimen Label: Skeletal
Specimen Num: 6
GXD Expression      
Probe: MGI:2681328
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2681335
Age: postnatal
Specimen Label: Heart
Detected: true
Specimen Num: 1
GXD Expression        
Probe: MGI:2681327
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2681336
Age: postnatal
Specimen Label: Heart
Specimen Num: 1
GXD Expression      
Probe: MGI:2681330
Assay Type: Western blot
Annotation Date: 2003-12-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:2681341
Age: embryonic day 9.5
Specimen Label: E9.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:2681330
Assay Type: Western blot
Annotation Date: 2003-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:2681341
Age: embryonic day 10.5
Specimen Label: E10.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2681330
Assay Type: Western blot
Annotation Date: 2003-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:2681341
Age: embryonic day 11.5
Specimen Label: E11.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2681330
Assay Type: Western blot
Annotation Date: 2003-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2681341
Age: embryonic day 12.5
Specimen Label: E12.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2681330
Assay Type: Western blot
Annotation Date: 2003-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:2681341
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 5
GXD Expression        
Probe: MGI:2681328
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2681335
Age: postnatal
Specimen Label: Liver
Specimen Num: 5
GXD Expression        
Probe: MGI:2681327
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2681336
Age: postnatal
Specimen Label: Liver
Specimen Num: 5
GXD Expression      
Probe: MGI:2681328
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:2681335
Age: postnatal
Specimen Label: Pancreas
Detected: true
Specimen Num: 8
GXD Expression        
Probe: MGI:2681327
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:2681336
Age: postnatal
Specimen Label: Pancreas
Specimen Num: 8
GXD Expression      
Probe: MGI:2681328
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2681335
Age: postnatal
Specimen Label: Brain
Detected: true
Specimen Num: 2
GXD Expression        
Probe: MGI:2681327
Assay Type: Northern blot
Annotation Date: 2003-12-16
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2681336
Age: postnatal
Specimen Label: Brain
Specimen Num: 2
GXD Expression    
Probe: MGI:453168
Assay Type: RNA in situ
Annotation Date: 2009-01-23
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1603911
Pattern: Ubiquitous
Stage: TS11
Assay Id: MGI:3828623
Age: embryonic day 7.5
Specimen Label: E7.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:453168
Assay Type: RNA in situ
Annotation Date: 2009-01-23
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Ubiquitous
Stage: TS13
Assay Id: MGI:3828623
Age: embryonic day 8.5
Specimen Label: E8.5
Detected: true
Specimen Num: 2
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Eid1/Eid1
Background: C57BL/6JGpt-Eid1/Gpt
Zygosity: hm
Has Mutant Allele: true
Allele
Name: E1A binding protein p300; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Genotype
Symbol: Eid2b/Eid2b<+>
Background: C57BL/6NJ-Eid2b/Mmjax
Zygosity: ht
Has Mutant Allele: true
Allele
Name: E1A binding protein p300; targeted mutation 1.1, William T Pu
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Publication  
First Author: Ji A
Year: 2003
Journal: Gene
Title: EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD.
Volume: 318
Pages: 35-43
Publication
First Author: BÃ¥vner A
Year: 2002
Journal: EMBO Rep
Title: A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP.
Volume: 3
Issue: 5
Pages: 478-84
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Genotype
Symbol: Ep300/Ep300
Background: involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Ye B
Year: 2014
Journal: Stem Cells
Title: Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability.
Volume: 32
Issue: 3
Pages: 623-35
Allele
Name: transgene insertion 19, Stephen N Jones
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
HT Experiment
Series Id: GSE24773
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Grégoire S
Year: 2005
Journal: Mol Cell Biol
Title: Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors.
Volume: 25
Issue: 6
Pages: 2273-87
Publication
First Author: Klein UR
Year: 2009
Journal: Mol Biol Cell
Title: RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin.
Volume: 20
Issue: 1
Pages: 410-8
Publication
First Author: Huang C
Year: 2009
Journal: EMBO J
Title: SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation.
Volume: 28
Issue: 18
Pages: 2748-62
Protein Domain
Type: Family
Description: Sentrin-specific protease 3 (SENP3, MEROPS identifier C48.003) is an isopeptidase that releases SUMO2 and SUMO3 monomers from sumoylated substrates by hydrolysing the isopeptide bond []. SENP3 is a cysteine peptidase with a fold similar to that of adenain, and has the catalytic triad His, Asp, Cys, the reverse of the order in papain. Among the proteins that are deconjugated by SENP3 are MEF2D [], CDCA8 [], EP300 [], and nucleophosmin []. SENP3 is a component of the 5FMC []and MLL1/MLL complexes [].
Strain
Attribute String: targeted mutation, mutant stock
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Li Y
Year: 2018
Journal: Nat Commun
Title: Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome.
Volume: 9
Issue: 1
Pages: 2494
Publication  
First Author: Li X
Year: 2022
Journal: Cancer Lett
Title: Disruption of enhancer-driven S100A14 expression promotes esophageal carcinogenesis.
Volume: 545
Pages: 215833
Publication
First Author: Peifer M
Year: 2012
Journal: Nat Genet
Title: Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
Volume: 44
Issue: 10
Pages: 1104-10
Publication
First Author: Son SM
Year: 2020
Journal: Nat Commun
Title: Leucine regulates autophagy via acetylation of the mTORC1 component raptor.
Volume: 11
Issue: 1
Pages: 3148
Publication
First Author: Houri K
Year: 2020
Journal: Sci Rep
Title: miR-142 induces accumulation of reactive oxygen species (ROS) by inhibiting pexophagy in aged bone marrow mesenchymal stem cells.
Volume: 10
Issue: 1
Pages: 3735
Publication
First Author: Xu W
Year: 2000
Journal: Nat Genet
Title: Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development.
Volume: 26
Issue: 2
Pages: 229-32
Publication
First Author: Bamforth SD
Year: 2001
Journal: Nat Genet
Title: Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.
Volume: 29
Issue: 4
Pages: 469-74
Publication
First Author: Janardhan HP
Year: 2017
Journal: J Clin Invest
Title: Hdac3 regulates lymphovenous and lymphatic valve formation.
Volume: 127
Issue: 11
Pages: 4193-4206
Publication
First Author: Sacilotto N
Year: 2016
Journal: Genes Dev
Title: MEF2 transcription factors are key regulators of sprouting angiogenesis.
Volume: 30
Issue: 20
Pages: 2297-2309
Publication
First Author: Tallack MR
Year: 2012
Journal: Genome Res
Title: Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq.
Volume: 22
Issue: 12
Pages: 2385-98
Publication
First Author: Cotney J
Year: 2012
Journal: Genome Res
Title: Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb.
Volume: 22
Issue: 6
Pages: 1069-80
Publication
First Author: Wajapeyee N
Year: 2013
Journal: Genes Dev
Title: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors.
Volume: 27
Issue: 20
Pages: 2221-6
Publication
First Author: Liu R
Year: 2012
Journal: Neurobiol Dis
Title: Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease.
Volume: 45
Issue: 3
Pages: 902-12
Publication
First Author: Forwood JK
Year: 2001
Journal: J Biol Chem
Title: The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.
Volume: 276
Issue: 49
Pages: 46575-82
Publication
First Author: Anson BJ
Year: 1967
Journal: Arch Otolaryngol
Title: The vestibular system. Anatomic considerations.
Volume: 85
Issue: 5
Pages: 497-514
Publication
First Author: Phillips NB
Year: 2006
Journal: J Mol Biol
Title: SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.
Volume: 358
Issue: 1
Pages: 172-92
Publication
First Author: Kellermayer R
Year: 2005
Journal: Diagn Mol Pathol
Title: A novel frame shift mutation in the HMG box of the SRY gene in a patient with complete 46,XY pure gonadal dysgenesis.
Volume: 14
Issue: 3
Pages: 159-63
Publication
First Author: Ogata T
Year: 1995
Journal: Hum Genet
Title: Turner syndrome and female sex chromosome aberrations: deduction of the principal factors involved in the development of clinical features.
Volume: 95
Issue: 6
Pages: 607-29
Publication
First Author: Maier EM
Year: 2003
Journal: J Pediatr Endocrinol Metab
Title: True hermaphroditism in an XY individual due to a familial point mutation of the SRY gene.
Volume: 16
Issue: 4
Pages: 575-80
Publication
First Author: Gong L
Year: 2006
Journal: J Biol Chem
Title: Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.
Volume: 281
Issue: 23
Pages: 15869-77
Protein Domain
Type: Homologous_superfamily
Description: CBP (CREB-binding protein) and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. The catalytic core of animal CBP-p300 contains a bromodomain, a CH2 region containing a discontinuous PHD domain interrupted by this RING domain, and a HAT domain. Bromodomain-RING-PHD forms a compact module in which the RING domain is juxtaposed with the HAT substrate-binding site. This ring domain contains only a single zinc ion-binding cluster instead of two; instead of a second zinc atom, a network of hydrophobic interactions stabilizes the domain. The RING domain has an inhibitory role. Disease mutations that disrupt RING attachment lead to upregulation of HAT activity. HAT regulation may require repositioning of the RING domain to facilitate access to an otherwise partially occluded HAT active site. Plant CBP-p300 type HATs lack a bromodomain whose role in the animal animal CBP-p300's is to bind acetylated histones; it has been suggested that these plant proteins may utilize a different domain or another bromodomain protein to perform this function [].
Protein Domain
Type: Domain
Description: CBP (CREB-binding protein) and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. The catalytic core of animal CBP-p300 contains a bromodomain, a CH2 region containing a discontinuous PHD domain interrupted by this RING domain, and a HAT domain. Bromodomain-RING-PHD forms a compact module in which the RING domain is juxtaposed with the HAT substrate-binding site. This ring domain contains only a single zinc ion-binding cluster instead of two; instead of a second zinc atom, a network of hydrophobic interactions stabilizes the domain. The RING domain has an inhibitory role. Disease mutations that disrupt RING attachment lead to upregulation of HAT activity. HAT regulation may require repositioning of the RING domain to facilitate access to an otherwise partially occluded HAT active site. Plant CBP-p300 type HATs lack a bromodomain whose role in the animal animal CBP-p300's is to bind acetylated histones; it has been suggested that these plant proteins may utilize a different domain or another bromodomain protein to perform this function []. This RING domain has also been referred to as DUF902.
Protein Domain
Type: Family
Description: This entry represents the testis-determining factor Sry (Sex-determining Region Y). Sry is a transcriptional activator that regulates a genetic switch inmale development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells []. Sry is involved in different aspects of gene regulation including promoter activation or repression and contains a high-mobility-group (HMG) box that recognises DNA by partial intercalation in the minor groove []. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Sry also facilitates DNA bending and is involved in pre-mRNA splicing. It is also involved in maintenance of motor functions of dopaminergic neurons in the male adult brain. Sry interacts with a number of partners, including CALM, EP300 (modulates Sry DNA-binding activity), HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1 (impaired Sry DNA-binding activity), SLC9A3R2 and WT1. The C-terminal nuclear localization signal in Sry HMG-box domain mediates nuclear import through importin beta 1 [].Defects in Sry can cause gonadal dysgenesis XY female type (GDXY) (OMIM:306100), which is also known as 'XY females' or Swyer syndrome []. Patients suffer rapid and early degeneration of their gonads, which prevents the development secondary sexual characteristics at puberty. Defects in Sry are also found Turner's Syndrome, a disease characterised by gonadal dysgenesis in a 45,X female type []. Defects in Sry can also cause true hermaphroditism (OMIM:235600), genetically heterogeneous condition whre patients have both mature ovarian and mature testicular tissue (46,XX, 46,XY or a mosaic of 46,XX/46,XY) [].
Publication
First Author: Steinman HA
Year: 2004
Journal: J Biol Chem
Title: An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.
Volume: 279
Issue: 6
Pages: 4877-86
Publication
First Author: Delvecchio M
Year: 2013
Journal: Nat Struct Mol Biol
Title: Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.
Volume: 20
Issue: 9
Pages: 1040-6
Publication
First Author: Fanis P
Year: 2012
Journal: Mol Cell Proteomics
Title: Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
Volume: 11
Issue: 11
Pages: 1263-73
Publication
First Author: Haindl M
Year: 2008
Journal: EMBO Rep
Title: The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing.
Volume: 9
Issue: 3
Pages: 273-9
Protein
Organism: Mus musculus/domesticus
Length: 392  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 568  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true