Type |
Details |
Score |
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Diez E |
Year: |
2011 |
Journal: |
Genes Immun |
Title: |
Identification and characterization of Cri1, a locus controlling mortality during Citrobacter rodentium infection in mice. |
Volume: |
12 |
Issue: |
4 |
Pages: |
280-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carim L |
Year: |
2000 |
Journal: |
Cytogenet Cell Genet |
Title: |
Identification and expression analysis of C15orf3, a novel gene on chromosome 15q21.1-->q21.2. |
Volume: |
88 |
Issue: |
3-4 |
Pages: |
330-2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lizcano F |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
EID1-induces brown-like adipocyte traits in white 3T3-L1 pre-adipocytes. |
Volume: |
398 |
Issue: |
2 |
Pages: |
160-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fu X |
Year: |
2019 |
Journal: |
Gene |
Title: |
Transcriptome profiling in Eid1-KO mice brain shows that Eid1 links cell proliferation in the brain. |
Volume: |
717 |
|
Pages: |
143998 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681328 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681335 |
Age: |
postnatal |
|
|
Specimen Label: |
Kidney |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681327 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681336 |
Age: |
postnatal |
|
|
Specimen Label: |
Kidney |
|
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681328 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681335 |
Age: |
postnatal |
|
|
Specimen Label: |
Placenta |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681327 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568928 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681336 |
Age: |
postnatal |
|
|
Specimen Label: |
Placenta |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681328 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681335 |
Age: |
postnatal |
|
|
Specimen Label: |
Lung |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681327 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681336 |
Age: |
postnatal |
|
|
Specimen Label: |
Lung |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681328 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:3598828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681335 |
Age: |
postnatal |
|
|
Specimen Label: |
Skeletal |
|
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681327 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:3598828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681336 |
Age: |
postnatal |
|
|
Specimen Label: |
Skeletal |
|
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681328 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681335 |
Age: |
postnatal |
|
|
Specimen Label: |
Heart |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681327 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681336 |
Age: |
postnatal |
|
|
Specimen Label: |
Heart |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681330 |
Assay Type: |
Western blot |
Annotation Date: |
2003-12-16 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603915 |
|
Stage: |
TS15 |
Assay Id: |
MGI:2681341 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
E9.5 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681330 |
Assay Type: |
Western blot |
Annotation Date: |
2003-12-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:2681341 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
E10.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681330 |
Assay Type: |
Western blot |
Annotation Date: |
2003-12-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:2681341 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
E11.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681330 |
Assay Type: |
Western blot |
Annotation Date: |
2003-12-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603920 |
|
Stage: |
TS20 |
Assay Id: |
MGI:2681341 |
Age: |
embryonic day 12.5 |
|
|
Specimen Label: |
E12.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681330 |
Assay Type: |
Western blot |
Annotation Date: |
2003-12-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603922 |
|
Stage: |
TS22 |
Assay Id: |
MGI:2681341 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
E14.5 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681328 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681335 |
Age: |
postnatal |
|
|
Specimen Label: |
Liver |
|
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681327 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681336 |
Age: |
postnatal |
|
|
Specimen Label: |
Liver |
|
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681328 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681335 |
Age: |
postnatal |
|
|
Specimen Label: |
Pancreas |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681327 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681336 |
Age: |
postnatal |
|
|
Specimen Label: |
Pancreas |
|
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681328 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681335 |
Age: |
postnatal |
|
|
Specimen Label: |
Brain |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2681327 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-12-16 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2681336 |
Age: |
postnatal |
|
|
Specimen Label: |
Brain |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:453168 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-23 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
Pattern: |
Ubiquitous |
Stage: |
TS11 |
Assay Id: |
MGI:3828623 |
Age: |
embryonic day 7.5 |
|
|
Specimen Label: |
E7.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:453168 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-23 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603913 |
Pattern: |
Ubiquitous |
Stage: |
TS13 |
Assay Id: |
MGI:3828623 |
Age: |
embryonic day 8.5 |
|
|
Specimen Label: |
E8.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Eid1/Eid1 |
Background: |
C57BL/6JGpt-Eid1/Gpt |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
E1A binding protein p300; targeted mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Eid2b/Eid2b<+> |
Background: |
C57BL/6NJ-Eid2b/Mmjax |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
E1A binding protein p300; targeted mutation 1.1, William T Pu |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Ji A |
Year: |
2003 |
Journal: |
Gene |
Title: |
EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD. |
Volume: |
318 |
|
Pages: |
35-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
BÃ¥vner A |
Year: |
2002 |
Journal: |
EMBO Rep |
Title: |
A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP. |
Volume: |
3 |
Issue: |
5 |
Pages: |
478-84 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ep300/Ep300 |
Background: |
involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye B |
Year: |
2014 |
Journal: |
Stem Cells |
Title: |
Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability. |
Volume: |
32 |
Issue: |
3 |
Pages: |
623-35 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 19, Stephen N Jones |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE24773 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Grégoire S |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. |
Volume: |
25 |
Issue: |
6 |
Pages: |
2273-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klein UR |
Year: |
2009 |
Journal: |
Mol Biol Cell |
Title: |
RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin. |
Volume: |
20 |
Issue: |
1 |
Pages: |
410-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang C |
Year: |
2009 |
Journal: |
EMBO J |
Title: |
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. |
Volume: |
28 |
Issue: |
18 |
Pages: |
2748-62 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Sentrin-specific protease 3 (SENP3, MEROPS identifier C48.003) is an isopeptidase that releases SUMO2 and SUMO3 monomers from sumoylated substrates by hydrolysing the isopeptide bond []. SENP3 is a cysteine peptidase with a fold similar to that of adenain, and has the catalytic triad His, Asp, Cys, the reverse of the order in papain. Among the proteins that are deconjugated by SENP3 are MEF2D [], CDCA8 [], EP300 [], and nucleophosmin []. SENP3 is a component of the 5FMC []and MLL1/MLL complexes []. |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome. |
Volume: |
9 |
Issue: |
1 |
Pages: |
2494 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2022 |
Journal: |
Cancer Lett |
Title: |
Disruption of enhancer-driven S100A14 expression promotes esophageal carcinogenesis. |
Volume: |
545 |
|
Pages: |
215833 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peifer M |
Year: |
2012 |
Journal: |
Nat Genet |
Title: |
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. |
Volume: |
44 |
Issue: |
10 |
Pages: |
1104-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Son SM |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Leucine regulates autophagy via acetylation of the mTORC1 component raptor. |
Volume: |
11 |
Issue: |
1 |
Pages: |
3148 |
|
•
•
•
•
•
|
Publication |
First Author: |
Houri K |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
miR-142 induces accumulation of reactive oxygen species (ROS) by inhibiting pexophagy in aged bone marrow mesenchymal stem cells. |
Volume: |
10 |
Issue: |
1 |
Pages: |
3735 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu W |
Year: |
2000 |
Journal: |
Nat Genet |
Title: |
Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. |
Volume: |
26 |
Issue: |
2 |
Pages: |
229-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bamforth SD |
Year: |
2001 |
Journal: |
Nat Genet |
Title: |
Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. |
Volume: |
29 |
Issue: |
4 |
Pages: |
469-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Janardhan HP |
Year: |
2017 |
Journal: |
J Clin Invest |
Title: |
Hdac3 regulates lymphovenous and lymphatic valve formation. |
Volume: |
127 |
Issue: |
11 |
Pages: |
4193-4206 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sacilotto N |
Year: |
2016 |
Journal: |
Genes Dev |
Title: |
MEF2 transcription factors are key regulators of sprouting angiogenesis. |
Volume: |
30 |
Issue: |
20 |
Pages: |
2297-2309 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tallack MR |
Year: |
2012 |
Journal: |
Genome Res |
Title: |
Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq. |
Volume: |
22 |
Issue: |
12 |
Pages: |
2385-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cotney J |
Year: |
2012 |
Journal: |
Genome Res |
Title: |
Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. |
Volume: |
22 |
Issue: |
6 |
Pages: |
1069-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wajapeyee N |
Year: |
2013 |
Journal: |
Genes Dev |
Title: |
Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. |
Volume: |
27 |
Issue: |
20 |
Pages: |
2221-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu R |
Year: |
2012 |
Journal: |
Neurobiol Dis |
Title: |
Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease. |
Volume: |
45 |
Issue: |
3 |
Pages: |
902-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Forwood JK |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1. |
Volume: |
276 |
Issue: |
49 |
Pages: |
46575-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anson BJ |
Year: |
1967 |
Journal: |
Arch Otolaryngol |
Title: |
The vestibular system. Anatomic considerations. |
Volume: |
85 |
Issue: |
5 |
Pages: |
497-514 |
|
•
•
•
•
•
|
Publication |
First Author: |
Phillips NB |
Year: |
2006 |
Journal: |
J Mol Biol |
Title: |
SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending. |
Volume: |
358 |
Issue: |
1 |
Pages: |
172-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kellermayer R |
Year: |
2005 |
Journal: |
Diagn Mol Pathol |
Title: |
A novel frame shift mutation in the HMG box of the SRY gene in a patient with complete 46,XY pure gonadal dysgenesis. |
Volume: |
14 |
Issue: |
3 |
Pages: |
159-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogata T |
Year: |
1995 |
Journal: |
Hum Genet |
Title: |
Turner syndrome and female sex chromosome aberrations: deduction of the principal factors involved in the development of clinical features. |
Volume: |
95 |
Issue: |
6 |
Pages: |
607-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maier EM |
Year: |
2003 |
Journal: |
J Pediatr Endocrinol Metab |
Title: |
True hermaphroditism in an XY individual due to a familial point mutation of the SRY gene. |
Volume: |
16 |
Issue: |
4 |
Pages: |
575-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gong L |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. |
Volume: |
281 |
Issue: |
23 |
Pages: |
15869-77 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
CBP (CREB-binding protein) and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. The catalytic core of animal CBP-p300 contains a bromodomain, a CH2 region containing a discontinuous PHD domain interrupted by this RING domain, and a HAT domain. Bromodomain-RING-PHD forms a compact module in which the RING domain is juxtaposed with the HAT substrate-binding site. This ring domain contains only a single zinc ion-binding cluster instead of two; instead of a second zinc atom, a network of hydrophobic interactions stabilizes the domain. The RING domain has an inhibitory role. Disease mutations that disrupt RING attachment lead to upregulation of HAT activity. HAT regulation may require repositioning of the RING domain to facilitate access to an otherwise partially occluded HAT active site. Plant CBP-p300 type HATs lack a bromodomain whose role in the animal animal CBP-p300's is to bind acetylated histones; it has been suggested that these plant proteins may utilize a different domain or another bromodomain protein to perform this function []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
CBP (CREB-binding protein) and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. The catalytic core of animal CBP-p300 contains a bromodomain, a CH2 region containing a discontinuous PHD domain interrupted by this RING domain, and a HAT domain. Bromodomain-RING-PHD forms a compact module in which the RING domain is juxtaposed with the HAT substrate-binding site. This ring domain contains only a single zinc ion-binding cluster instead of two; instead of a second zinc atom, a network of hydrophobic interactions stabilizes the domain. The RING domain has an inhibitory role. Disease mutations that disrupt RING attachment lead to upregulation of HAT activity. HAT regulation may require repositioning of the RING domain to facilitate access to an otherwise partially occluded HAT active site. Plant CBP-p300 type HATs lack a bromodomain whose role in the animal animal CBP-p300's is to bind acetylated histones; it has been suggested that these plant proteins may utilize a different domain or another bromodomain protein to perform this function []. This RING domain has also been referred to as DUF902. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents the testis-determining factor Sry (Sex-determining Region Y). Sry is a transcriptional activator that regulates a genetic switch inmale development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells []. Sry is involved in different aspects of gene regulation including promoter activation or repression and contains a high-mobility-group (HMG) box that recognises DNA by partial intercalation in the minor groove []. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. Sry also facilitates DNA bending and is involved in pre-mRNA splicing. It is also involved in maintenance of motor functions of dopaminergic neurons in the male adult brain. Sry interacts with a number of partners, including CALM, EP300 (modulates Sry DNA-binding activity), HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1 (impaired Sry DNA-binding activity), SLC9A3R2 and WT1. The C-terminal nuclear localization signal in Sry HMG-box domain mediates nuclear import through importin beta 1 [].Defects in Sry can cause gonadal dysgenesis XY female type (GDXY) (OMIM:306100), which is also known as 'XY females' or Swyer syndrome []. Patients suffer rapid and early degeneration of their gonads, which prevents the development secondary sexual characteristics at puberty. Defects in Sry are also found Turner's Syndrome, a disease characterised by gonadal dysgenesis in a 45,X female type []. Defects in Sry can also cause true hermaphroditism (OMIM:235600), genetically heterogeneous condition whre patients have both mature ovarian and mature testicular tissue (46,XX, 46,XY or a mosaic of 46,XX/46,XY) []. |
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•
•
•
•
•
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Publication |
First Author: |
Steinman HA |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis. |
Volume: |
279 |
Issue: |
6 |
Pages: |
4877-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Delvecchio M |
Year: |
2013 |
Journal: |
Nat Struct Mol Biol |
Title: |
Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation. |
Volume: |
20 |
Issue: |
9 |
Pages: |
1040-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fanis P |
Year: |
2012 |
Journal: |
Mol Cell Proteomics |
Title: |
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. |
Volume: |
11 |
Issue: |
11 |
Pages: |
1263-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haindl M |
Year: |
2008 |
Journal: |
EMBO Rep |
Title: |
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing. |
Volume: |
9 |
Issue: |
3 |
Pages: |
273-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
392
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
568
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
234
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
233
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
416
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
302
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
300
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
232
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
231
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
395
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
315
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
304
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
232
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
317
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
306
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
374
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
303
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
315
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
233
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
143
|
Fragment?: |
true |
|
•
•
•
•
•
|