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Search results 201 to 300 out of 309 for Asxl1

0.072s
Type Details Score
GXD Expression      
Probe: MGI:4423076
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5422100
Age: embryonic day 14.5
Specimen Label: EB2031; Specimen B867
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423076
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5422100
Age: embryonic day 14.5
Specimen Label: EB2031; Specimen B867
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423076
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5422100
Age: embryonic day 14.5
Specimen Label: EB2031; Specimen B867
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423076
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5422100
Age: embryonic day 14.5
Specimen Label: EB2031; Specimen B867
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4423076
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5422100
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: EB2031; Specimen B867
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4423076
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5422100
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: EB2031; Specimen B867
Detected: false
Specimen Num: 1
Publication    
First Author: Perez-Garcia V
Year: 2021
Journal: Elife
Title: BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion.
Volume: 10
Publication
First Author: Tirado-Gonzalez I
Year: 2021
Journal: Cancer Discov
Title: AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia.
Volume: 11
Issue: 11
Pages: 2924-2943
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
Publication
First Author: Bassett JH
Year: 2012
Journal: PLoS Genet
Title: Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.
Volume: 8
Issue: 8
Pages: e1002858
Publication
First Author: McGinley AL
Year: 2014
Journal: Genesis
Title: Additional sex combs-like family genes are required for normal cardiovascular development.
Volume: 52
Issue: 7
Pages: 671-86
Publication
First Author: White JK
Year: 2013
Journal: Cell
Title: Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.
Volume: 154
Issue: 2
Pages: 452-64
Publication  
First Author: Millien G
Year: 2006
Journal: BMC Dev Biol
Title: Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development.
Volume: 6
Pages: 35
Publication  
First Author: Maga AM
Year: 2015
Journal: Front Physiol
Title: Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.
Volume: 6
Pages: 92
Publication
First Author: Tuck E
Year: 2015
Journal: Dis Model Mech
Title: A gene expression resource generated by genome-wide lacZ profiling in the mouse.
Volume: 8
Issue: 11
Pages: 1467-78
Publication
First Author: Thuret S
Year: 2004
Journal: Mol Cell Neurosci
Title: Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.
Volume: 25
Issue: 3
Pages: 394-405
Publication
First Author: Liu X
Year: 2016
Journal: BMC Immunol
Title: Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Volume: 17
Issue: 1
Pages: 25
Publication      
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
Publication      
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
Publication        
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
UniProt Feature
Begin: 1
Description: Polycomb group protein ASXL1
Type: chain
End: 1514
Publication
First Author: Sui P
Year: 2024
Journal: Leukemia
Title: SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis.
Volume: 38
Issue: 2
Pages: 408-411
Publication  
First Author: Ge G
Year: 2024
Journal: J Clin Invest
Title: Targeting lysine demethylase 6B ameliorates ASXL1 truncation-mediated myeloid malignancies in preclinical models.
Volume: 134
Issue: 1
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Toshio Kitamura
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, No functional change
Strain
Attribute String: congenic, mutant strain, targeted mutation
Allele
Name: transgene insertion, Feng-Chun Yang
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Genotype
Symbol: Tg(Vav1-Asxl1*Y588X)#Fcy/?
Background: C57BL/6-Tg(Vav1-Asxl1*Y588X)#Fcy
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: LaFave LM
Year: 2015
Journal: Nat Med
Title: Loss of BAP1 function leads to EZH2-dependent transformation.
Volume: 21
Issue: 11
Pages: 1344-9
Publication
First Author: Muto T
Year: 2013
Journal: J Exp Med
Title: Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders.
Volume: 210
Issue: 12
Pages: 2627-39
Publication
First Author: Bejar R
Year: 2014
Journal: Blood
Title: TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.
Volume: 124
Issue: 17
Pages: 2705-12
Publication
First Author: Abdel-Wahab O
Year: 2013
Journal: Leukemia
Title: The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics.
Volume: 27
Issue: 1
Pages: 10-5
Publication
First Author: Takeda R
Year: 2020
Journal: Blood
Title: HHEX promotes myeloid transformation in cooperation with mutant ASXL1.
Volume: 136
Issue: 14
Pages: 1670-1684
Protein
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: true
Publication  
First Author: Sahtoe DD
Year: 2016
Journal: Nat Commun
Title: BAP1/ASXL1 recruitment and activation for H2A deubiquitination.
Volume: 7
Pages: 10292
Publication
First Author: Daou S
Year: 2018
Journal: Nat Commun
Title: Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.
Volume: 9
Issue: 1
Pages: 4385
Publication
First Author: Foglizzo M
Year: 2018
Journal: Nat Commun
Title: A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes.
Volume: 9
Issue: 1
Pages: 3932
Publication
First Author: Sanchez-Pulido L
Year: 2012
Journal: Bioinformatics
Title: A common ancestry for BAP1 and Uch37 regulators.
Volume: 28
Issue: 15
Pages: 1953-6
Protein Domain
Type: Domain
Description: Protein ubiquitination is a fundamental mechanism that affects nearly all aspects of cellular life. Deubiquitinating enzymes (DUBs) play important roles in ubiquitin (Ub) signalling by Ub cleavage from adducts. The Ub C-terminal hydrolase (UCH) family of deubiquitinases (DUBs) contains four members including UCH37 (also called ubiquitin carboxy-terminal hydrolase isozyme L5, UCHL-5) and BAP1 which share high similarity in the catalytic domain (UCH) and the C-terminal region, termed the UCH37-like domain (ULD) which is responsible for binding interaction partners and is also involved in the regulation of DUB activity. ULD from BAP1 and UCH-L5 binds the DEUBiquitinase ADaptor (DEUBAD) domain present in their interacting partners, e.g., ASXL1 for BAP1, and RPN13 (ADRM1) and INO80G (NFRKB) for UCH-L5 [, , , , ].This entry represents the DEUBAD domain which consists of eight α-helices that form a helical bundle surrounding a compact hydrophobic core []. It has a modular architecture with the core formed by helices 1-4, primarily responsible for binding to ULD, and accessory elements that lead to full activation, or inhibition, of the UCH activity [, ].
Protein
Organism: Mus musculus/domesticus
Length: 1296  
Fragment?: false
Publication
First Author: De I
Year: 2019
Journal: Structure
Title: Structural Basis for the Activation of the Deubiquitinase Calypso by the Polycomb Protein ASX.
Volume: 27
Issue: 3
Pages: 528-536.e4
Publication
First Author: Jiao L
Year: 2014
Journal: Protein Cell
Title: Mechanism of the Rpn13-induced activation of Uch37.
Volume: 5
Issue: 8
Pages: 616-30
Publication
First Author: Sahtoe DD
Year: 2015
Journal: Mol Cell
Title: Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.
Volume: 57
Issue: 5
Pages: 887-900
Protein
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
Protein Domain
Type: Domain
Description: This domain, known as the HARE-HTH domain, adopts the winged helix-turn-helix fold and is predicted to bind DNA. It can be found at the N terminus of the ASXL protein. It can also be found in several other eukaryotic chromatin proteins (such as HB1 in plants), diverse restriction endonucleases and DNA glycosylases, the RNA polymerase delta subunit of Gram-positive bacteria and certain bacterial proteins that combine features of the RNA polymerase alpha-subunit and sigma factors []. The genetic interaction of the HARE-HTH containing ASXL with the methyl cytosine hydroxylating Tet2 protein is suggestive of a role for the domain in discriminating sequences with DNA modifications such as hmC []. Bacterial versions include fusions to diverse restriction endonucleases, and a DNA glycosylase where it may play a similar role in detecting modified DNA. Certain bacterial version of the HARE-HTH domain show fusions to the helix-hairpin-helix domain of the RNA polymerase alpha subunit and the HTH domains found in regions 3 and 4 of the sigma factors []. These versions are predicted to function as a novel inhibitor of the binding of RNA polymerase to transcription start sites, similar to the Bacillus delta protein [, ].This domain consists of four α-helices (helices I-II-III-IV) and an antiparallel β-sheet composed of three short β-strands at the top of a "twisted tripod"formed by helices II, III, and IV [].The Asx-like (Asxl) proteins includes Asxl1-3. They are putative Polycomb group (PcG) proteins, which act by forming multiprotein complexes that are required to maintain the transcriptionally repressive state of homeotic genes throughout development. Asxl1 is involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) [].The delta protein is a dispensable subunit of Bacillus subtilis RNA polymerase (RNAP) that has major effects on the biochemical properties of the purified enzyme. In the presence of delta, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increasedefficiency of RNA synthesis because of enhanced recycling []. The delta protein, contains two distinct regions, an N-terminal domain and a glutamate and aspartate residue-rich C-terminal region []. It participates in both the initiation and recycling phases of transcription.
Protein
Organism: Mus musculus/domesticus
Length: 1370  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2259  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1418  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1370  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 597  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1370  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 2260  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 495  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: true
Publication
First Author: López de Saro FJ
Year: 1999
Journal: J Biol Chem
Title: Expression, abundance, and RNA polymerase binding properties of the delta factor of Bacillus subtilis.
Volume: 274
Issue: 22
Pages: 15953-8
Publication
First Author: López de Saro FJ
Year: 1995
Journal: J Mol Biol
Title: Structural analysis of the Bacillus subtilis delta factor: a protein polyanion which displaces RNA from RNA polymerase.
Volume: 252
Issue: 2
Pages: 189-202
Publication
First Author: Motácková V
Year: 2010
Journal: Proteins
Title: Solution structure of the N-terminal domain of Bacillus subtilis delta subunit of RNA polymerase and its classification based on structural homologs.
Volume: 78
Issue: 7
Pages: 1807-10