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Search results 201 to 221 out of 221 for Ubr4

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0.017s

Type

Details

Score

Protein Domain

IPR045841 | E3_UBR4_N

Type:

Domain

Description:

This entry represents the N-terminal domain of E3 ubiquitin-protein ligases UBR4 (POE or PUSHOVER in Drosophila) from animals. UBR4 is a component of the N-rule pathway, identified as noncanonical N-recognins implicated in bulk lysosomal degradation and autophagy. Proteins containing this domain are extraordinarily large proteins that recognise and bind to proteins with N-terminal destabilising residues according to the N-end rule leading them to their ubiquitination and degradation. These proteins share a UBR box with others E3-ligases UBR box proteins, but UBR4 lacks the ubiquitylation domain, suggesting that it may interact with other catalytic proteins [, , ].

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Publication

16214886 | -

First Author:	Nakatani Y
Year:	2005
Journal:	Proc Natl Acad Sci U S A
Title:	p600, a unique protein required for membrane morphogenesis and cell survival.
Volume:	102
Issue:	42
Pages:	15093-8

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Publication

11485992 | -

First Author:	Gil P
Year:	2001
Journal:	Genes Dev
Title:	BIG: a calossin-like protein required for polar auxin transport in Arabidopsis.
Volume:	15
Issue:	15
Pages:	1985-97

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Publication

8314087 | -

First Author:	Li HM
Year:	1994
Journal:	Genes Dev
Title:	Arabidopsis mutants define downstream branches in the phototransduction pathway.
Volume:	8
Issue:	3
Pages:	339-49

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Publication

9165751 | -

First Author:	Ruegger M
Year:	1997
Journal:	Plant Cell
Title:	Reduced naphthylphthalamic acid binding in the tir3 mutant of Arabidopsis is associated with a reduction in polar auxin transport and diverse morphological defects.
Volume:	9
Issue:	5
Pages:	745-57

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Publication

9390435 | -

First Author:	Sponsel VM
Year:	1997
Journal:	Plant Physiol
Title:	Characterization of new gibberellin-responsive semidwarf mutants of arabidopsis.
Volume:	115
Issue:	3
Pages:	1009-20

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Publication

12834402 | -

First Author:	Kanyuka K
Year:	2003
Journal:	Plant J
Title:	Mutations in the huge Arabidopsis gene BIG affect a range of hormone and light responses.
Volume:	35
Issue:	1
Pages:	57-70

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Publication

15634200 | -

First Author:	Desgagné-Penix I
Year:	2005
Journal:	Plant J
Title:	The auxin transport inhibitor response 3 (tir3) allele of BIG and auxin transport inhibitors affect the gibberellin status of Arabidopsis.
Volume:	41
Issue:	2
Pages:	231-42

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Publication

15681664 | -

First Author:	López-Bucio J
Year:	2005
Journal:	Plant Physiol
Title:	An auxin transport independent pathway is involved in phosphate stress-induced root architectural alterations in Arabidopsis. Identification of BIG as a mediator of auxin in pericycle cell activation.
Volume:	137
Issue:	2
Pages:	681-91

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Publication

17652113 | -

First Author:	Yamaguchi N
Year:	2007
Journal:	Plant Cell Physiol
Title:	CRM1/BIG-mediated auxin action regulates Arabidopsis inflorescence development.
Volume:	48
Issue:	9
Pages:	1275-90

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Publication

19176721 | -

First Author:	Contreras-Cornejo HA
Year:	2009
Journal:	Plant Physiol
Title:	Trichoderma virens, a plant beneficial fungus, enhances biomass production and promotes lateral root growth through an auxin-dependent mechanism in Arabidopsis.
Volume:	149
Issue:	3
Pages:	1579-92

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Publication

11517334 | -

First Author:	Yager J
Year:	2001
Journal:	Proc Natl Acad Sci U S A
Title:	Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways.
Volume:	98
Issue:	18
Pages:	10445-50

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Publication

9813038 | -

First Author:	Xu XZ
Year:	1998
Journal:	J Biol Chem
Title:	Retinal targets for calmodulin include proteins implicated in synaptic transmission.
Volume:	273
Issue:	47
Pages:	31297-307

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Publication

8244010 | -

First Author:	Castrillon DH
Year:	1993
Journal:	Genetics
Title:	Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis.
Volume:	135
Issue:	2
Pages:	489-505

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Publication

25424645 | -

First Author:	Parsons K
Year:	2015
Journal:	Cell Mol Life Sci
Title:	p600/UBR4 in the central nervous system.
Volume:	72
Issue:	6
Pages:	1149-60

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Protein Domain

IPR025704 | E3_Ub_ligase_UBR4_C

Type:

Domain

Description:

Proteins containing this domain includes E3 ubiquitin ligase UBR4 from animals, auxin transport protein BIG from plants and protein purity of essence from fruit flies.UBR4, also known as p600, is a member of the N-recognin family, which contains proven and predicted E3 ligases that recognize and degrade proteins containing destabilizing N termini []. It is involved in anoikis, viral transformation and protein degradation [, ]. It also has roles in neurogenesis, neuronal migration, neuronal signaling and survival in mammalian brains [].BIG is required for auxin efflux and polar auxin transport (PAT) influencing auxin-mediated developmental responses (e.g. cell elongation, apical dominance, lateral root production, inflorescence architecture, general growth and development) []. Auxin transport protein is also involved in the elongation of the pedicels and stem internodes through auxin action, the expression/modulation of light-regulated genes, repression of CAB1 and CAB3 genes in etiolated seedlings, etc [, , , , , , , ].Protein purity of essence, found in Drosophila melanogaster, has a role in growth of the perineurial glial layer of the larval peripheral nerve and it may have a role in male fertility and eye development or function [, , ].

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Protein Domain

IPR045189 | UBR4-like

Type:

Family

Description:

This entry includes E3 ubiquitin ligase UBR4 from animals, auxin transport protein BIG from plants and protein purity of essence from fruit flies.UBR4, also known as p600, is a member of the N-recognin family, which contains proven and predicted E3 ligases that recognise and degrade proteins containing destabilising N termini []. It is involved in anoikis, viral transformation and protein degradation [, ]. It also has roles in neurogenesis, neuronal migration, neuronal signaling and survival in mammalian brains [].BIG is required for auxin efflux and polar auxin transport (PAT) influencing auxin-mediated developmental responses (e.g. cell elongation, apical dominance, lateral root production, inflorescence architecture, general growth and development) []. Auxin transport protein is also involved in the elongation of the pedicels and stem internodes through auxin action, the expression/modulation of light-regulated genes, repression of CAB1 and CAB3 genes in etiolated seedlings, etc [, , , , , , , ].Protein purity of essence, found in Drosophila melanogaster, has a role in growth of the perineurial glial layer of the larval peripheral nerve and it may have a role in male fertility and eye development or function [, , ].

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Publication

17242355 | -

First Author:	Villén J
Year:	2007
Journal:	Proc Natl Acad Sci U S A
Title:	Large-scale phosphorylation analysis of mouse liver.
Volume:	104
Issue:	5
Pages:	1488-93

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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