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Search results 101 to 200 out of 249 for Rpia

0.035s
Type Details Score
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1781522
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759722
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1672722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Image: EB2426; Specimen B935
Specimen Label: EB2426; Specimen B935
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1775122
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274122
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287422
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3266022
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1624622
Pattern: Ubiquitous
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Image: EB2426; Specimen B935
Note: Expression was detected in the digestive system.
Specimen Label: EB2426; Specimen B935
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721422
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1646922
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683322
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1700022
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1832122
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Note: Expression was not detected in the immune system.
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741222
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287022
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1821522
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702122
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4417093
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5421944
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: EB2426; Specimen B935
Detected: false
Specimen Num: 1
Publication
First Author: Gumaa KA
Year: 1969
Journal: Biochem J
Title: The pentose phosphate pathway of glucose metabolism. Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells.
Volume: 115
Issue: 5
Pages: 1009-29
Publication
First Author: Poltorak A
Year: 2001
Journal: J Immunol
Title: A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice.
Volume: 167
Issue: 4
Pages: 2106-11
Publication
First Author: Cossette SM
Year: 2014
Journal: Biol Open
Title: Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.
Volume: 4
Issue: 1
Pages: 48-61
Publication
First Author: Bowman CE
Year: 2016
Journal: Mol Cell Biol
Title: Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
Volume: 36
Issue: 15
Pages: 2089-104
Publication
First Author: Bulusu V
Year: 2017
Journal: Dev Cell
Title: Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Volume: 40
Issue: 4
Pages: 331-341.e4
Publication      
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication        
First Author: Haiming Tang, Dustin Ebert, Matthias Blum, Robert Finn, Paul Thomas
Year: 2023
Title: TreeGrafter-generated GO annotations
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Protein Domain
Type: Family
Description: Ribose 5-phosphate isomerase () forms a homodimer and catalyses the interconversion of D-ribose 5-phosphate and D-ribulose 5-phosphate in the non-oxidative branch of the pentose phosphate pathway. This reaction permits the synthesis of ribose from other sugars, as well as the recycling of sugars from nucleotide breakdown. Two unrelated enzymes can catalyse this reaction: RpiA (found in most organisms) and RpiB (found in some bacteria and eukaryotes). RpiB is also involved in metabolism of the rare sugar, allose, in addition to ribose sugars. The structures of RpiA and RpiB are distinct, RpiB having a Rossmann-type alpha/beta/alpha sandwich topology [].This entry represents the RpiB enzyme. It also includes D-erythrulose-4-phosphate isomerase from Pectobacterium atrosepticum [].
Publication
First Author: Rangarajan ES
Year: 2002
Journal: Proteins
Title: Crystal structure of D-ribose-5-phosphate isomerase (RpiA) from Escherichia coli.
Volume: 48
Issue: 4
Pages: 737-40
Publication
First Author: Zhang Rg
Year: 2003
Journal: Structure
Title: Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle.
Volume: 11
Issue: 1
Pages: 31-42
Publication
First Author: Delarue M
Year: 2007
Journal: J Mol Biol
Title: Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei.
Volume: 366
Issue: 3
Pages: 868-81
Protein Domain
Type: Homologous_superfamily
Description: This entry is composed of multiple transferases, mainly ribose-5-phosphate isomerase A (RpiA), glucosamine-6-phosphate deaminase (NagB) and 6-phosphogluconolactonase (6PGL). RpiA and 6PGL are involved in the pentose phosphate pathway while NagB is involved in the last step of the N-acetylneuraminate degradation pathway. These enzymes share a common core α/β structure [].
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
Publication
First Author: Zhang RG
Year: 2003
Journal: J Mol Biol
Title: The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction.
Volume: 332
Issue: 5
Pages: 1083-94
Publication
First Author: Carter MS
Year: 2018
Journal: Nat Chem Biol
Title: Functional assignment of multiple catabolic pathways for D-apiose.
Volume: 14
Issue: 7
Pages: 696-705
Protein Domain
Type: Family
Description: Ribose 5-phosphate isomerase, also known as phosphoriboisomerase, catalyses the reversible conversion of D-ribose 5-phosphate to D-ribulose 5-phosphate, the first step in the non-oxidative branch of the pentose phosphate pathway []. This reaction enables ribose to be synthesized from sugars, as well as the recycling of sugars during the degradation of nucleotides. There are two unrelated types of ribose 5-phosphate isomerases: type A (RpiA) is the most common and is found in most organisms, while type B (RpiB) is restricted to specific eukaryotic and prokaryotic species. Escherichia coli produces both RpiA and RpiB (also known as AlsB), although RpiA accounts for 99% of total RPI enzymes []. This entry represents type A (RpiA) enzymes found in eukaryotes (plants, Metazoa and fungi), bacteria and archaea.
Protein Domain
Type: Family
Description: Ribose 5-phosphate isomerase, also known as phosphoriboisomerase, catalyses the reversible conversion of D-ribose 5-phosphate to D-ribulose 5-phosphate, the first step in the non-oxidative branch of the pentose phosphate pathway []. This reaction enables ribose to be synthesized from sugars, as well as the recycling of sugars during the degradation of nucleotides. There are two unrelated types of ribose 5-phosphate isomerases: type A (RpiA) is the most common and is found in most organisms, while type B (RpiB) is restricted to specific eukaryotic and prokaryotic species. Escherichia coli produces both RpiA and RpiB (also known as AlsB), although RpiA accounts for 99% of total RPI enzymes []. This entry represents a subgroup of type A ribose-5-phosphate isomerase that is found in bacteria, archaea and eukaryotes (plants and Metazoa), but excluding those found in fungi.
Protein Domain
Type: Family
Description: This entry represents the sugar isomerase enzymes ribose 5-phosphate isomerase B (RpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB). Galactose-6-phosphate isomerase () is a heteromultimeric protein consisting of subunits LacA and LacB, and catalyses the conversion of D-galactose 6-phosphate to D-tagatose and 6-phosphate in the tagatose 6-phosphate pathway of lactose catabolism []. Galactose-6-phosphate isomerase is induced by galactose or lactose.Ribose 5-phosphate isomerase () forms a homodimer and catalyses the interconversion of D-ribose 5-phosphate and D-ribulose 5-phosphate in the non-oxidative branch of the pentose phosphate pathway. This reaction permits the synthesis of ribose from other sugars, as well as the recycling of sugars from nucleotide breakdown. Two unrelated enzymes can catalyse this reaction: RpiA (found in most organisms) and RpiB (found in some bacteria and eukaryotes). RpiB is also involved in metabolism of the rare sugar, allose, in addition to ribose sugars. The structures of RpiA and RpiB are distinct, RpiB having a Rossmann-type alpha/beta/alpha sandwich topology [].
Protein Domain
Type: Homologous_superfamily
Description: This entry represents the sugar isomerase enzymes ribose 5-phosphate isomerase B (RpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB). Galactose-6-phosphate isomerase () is a heteromultimeric protein consisting of subunits LacA and LacB, and catalyses the conversion of D-galactose 6-phosphate to D-tagatose and 6-phosphate in the tagatose 6-phosphate pathway of lactose catabolism []. Galactose-6-phosphate isomerase is induced by galactose or lactose.Ribose 5-phosphate isomerase () forms a homodimer and catalyses the interconversion of D-ribose 5-phosphate and D-ribulose 5-phosphate in the non-oxidative branch of the pentose phosphate pathway. This reaction permits the synthesis of ribose from other sugars, as well as the recycling of sugars from nucleotide breakdown. Two unrelated enzymes can catalyse this reaction: RpiA (found in most organisms) and RpiB (found in some bacteria and eukaryotes). RpiB is also involved in metabolism of the rare sugar, allose, in addition to ribose sugars. The structures of RpiA and RpiB are distinct, RpiB having a Rossmann-type alpha/beta/alpha sandwich topology [].
Protein Domain
Type: Domain
Description: RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, RpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate [].This domain is also found in other members of the RpiR family of transcriptional regulators, such as MurR []and in uncharacterised proteins of the UPF0309 family.
Publication
First Author: Sørensen KI
Year: 1996
Journal: J Bacteriol
Title: Ribose catabolism of Escherichia coli: characterization of the rpiB gene encoding ribose phosphate isomerase B and of the rpiR gene, which is involved in regulation of rpiB expression.
Volume: 178
Issue: 4
Pages: 1003-11
Publication
First Author: Rosey EL
Year: 1992
Journal: J Bacteriol
Title: Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutans.
Volume: 174
Issue: 19
Pages: 6159-70
Publication
First Author: Roos AK
Year: 2004
Journal: J Mol Biol
Title: Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site.
Volume: 335
Issue: 3
Pages: 799-809
Publication
First Author: Roos AK
Year: 2008
Journal: J Mol Biol
Title: D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not.
Volume: 382
Issue: 3
Pages: 667-79
Publication
First Author: Huang H
Year: 2015
Journal: J Am Chem Soc
Title: A General Strategy for the Discovery of Metabolic Pathways: d-Threitol, l-Threitol, and Erythritol Utilization in Mycobacterium smegmatis.
Volume: 137
Issue: 46
Pages: 14570-3
Protein Domain
Type: Family
Description: This family is a member of the RpiB/LacA/LacB family. It includes ribose 5-phosphate isomerases and D-erythrulose-4-phosphate isomerases []. The only candidates for ribose 5-phosphate isomerase in the Actinobacteria are members of this family [, ].Ribose 5-phosphate isomerase () forms a homodimer and catalyses the interconversion of D-ribose 5-phosphate and D-ribulose 5-phosphate in the non-oxidative branch of the pentose phosphate pathway. This reaction permits the synthesis of ribose from other sugars, as well as the recycling of sugars from nucleotide breakdown. Two unrelated enzymes can catalyse this reaction: RpiA (found in most organisms) and RpiB (found in some bacteria and eukaryotes).
Publication
First Author: Jaeger T
Year: 2008
Journal: J Bacteriol
Title: The transcriptional factors MurR and catabolite activator protein regulate N-acetylmuramic acid catabolism in Escherichia coli.
Volume: 190
Issue: 20
Pages: 6598-608
Protein
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 48  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true