Search our database by keyword

Examples

Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 324 out of 324 for Kmt2d

<< First < Previous | Next > Last >>

0.019s

Type

Details

Score

Publication

- | J:53168

First Author:	Bairoch A
Year:	1999
Journal:	Database Release
Title:	SWISS-PROT Annotated protein sequence database

•

Publication

- | J:262123

First Author:	Allen Institute for Brain Science
Year:	2004
Journal:	Allen Institute
Title:	Allen Brain Atlas: mouse riboprobes

•

Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

•

Publication

- | J:85324

First Author:	Mouse Genome Informatics Group
Year:	2003
Journal:	Database Procedure
Title:	Automatic Encodes (AutoE) Reference

•

Publication

- | J:155721

First Author:	Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year:	2010
Journal:	Database Download
Title:	Consensus CDS project

•

Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

•

Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

•

Publication

37822508 | J:341500

First Author:	Sanghrajka RM
Year:	2023
Journal:	iScience
Title:	KMT2D suppresses Sonic hedgehog-driven medulloblastoma progression and metastasis.
Volume:	26
Issue:	10
Pages:	107831

•

HT Experiment

GSE149688 | The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

•

Publication

36525973 | J:336850

First Author:	Pan Y
Year:	2023
Journal:	Cancer Cell
Title:	KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition.
Volume:	41
Issue:	1
Pages:	88-105.e8

•

HT Experiment

E-GEOD-74679 | Analysis of transcriptome changes in Kmt2d deletion in cardiac mesoderm, anterior heart field precursors and cardiomyocytes

Series Id:	GSE74679
Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

Publication

27280393 | J:234839

First Author:	Dawkins JB
Year:	2016
Journal:	Cancer Res
Title:	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.
Volume:	76
Issue:	16
Pages:	4861-71

•

Publication

32887696 | J:299189

First Author:	Wang G
Year:	2020
Journal:	Cancer Discov
Title:	CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade.
Volume:	10
Issue:	12
Pages:	1912-1933

•

Protein Domain

IPR041964 | KMT2D_ePHD2

Type:

Domain

Description:

The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. KMT2D, also known as ALR or MLL4, is a fourth human homologue of Drosophila trithorax, located on chromosome 12 []. KMT2D enzymatically generates trimethylated histone H3 at Lys 4 (H3K4me3). It acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription []. It is also a part of activating signal cointegrator-2 (ASC-2)-containing complex (ASCOM) that contains the transcriptional coactivator nuclear receptor coactivator 6 (NCOA6), KMT2C and KMT2D. The ASCOM complex is critical for nuclear receptor (NR) activation of bile acid transporter genes and is down regulated in cholestasis []. KMT2D contains the catalytic domain SET, five PHD fingers, two ePHD fingers, a RING finger, an HMG (high-mobility group)-binding motif, and two FY-rich regions.Mutations in the KMT2D gene have been linked to Kabuki syndrome [, ].This entry represents the second ePHD finger of Histone-lysine N-methyltransferase 2D (KMT2D).

•

Protein Domain

IPR041961 | KMT2D_ePHD1

Type:

Domain

Description:

This entry represents the first ePHD finger of Histone-lysine N-methyltransferase 2D (KMT2D).The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. KMT2D, also known as ALR or MLL4, is a fourth human homologue of Drosophila trithorax, located on chromosome 12 []. KMT2D enzymatically generates trimethylated histone H3 at Lys 4 (H3K4me3). It acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription []. It is also a part of activating signal cointegrator-2 (ASC-2)-containing complex (ASCOM) that contains the transcriptional coactivator nuclear receptor coactivator 6 (NCOA6), KMT2C and KMT2D. The ASCOM complex is critical for nuclear receptor (NR) activation of bile acid transporter genes and is down regulated in cholestasis []. KMT2D contains the catalytic domain SET, five PHD fingers, two ePHD fingers, a RING finger, an HMG (high-mobility group)-binding motif, and two FY-rich regions.Mutations in the KMT2D gene have been linked to Kabuki syndrome [, ].

•

Publication

30514738 | -

First Author:	Adam MP
Year:	2019
Journal:	J Med Genet
Title:	Kabuki syndrome: international consensus diagnostic criteria.
Volume:	56
Issue:	2
Pages:	89-95

•

Publication

21280141 | -

First Author:	Paulussen AD
Year:	2011
Journal:	Hum Mutat
Title:	MLL2 mutation spectrum in 45 patients with Kabuki syndrome.
Volume:	32
Issue:	2
Pages:	E2018-25

•

Publication

30232013 | J:271715

First Author:	Bouchard C
Year:	2018
Journal:	Cell Rep
Title:	Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes.
Volume:	24
Issue:	12
Pages:	3339-3352

•

Publication

30753827 | J:271283

First Author:	Skvortsova K
Year:	2019
Journal:	Cancer Cell
Title:	DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns.
Volume:	35
Issue:	2
Pages:	297-314.e8

•

Publication

9247308 | J:42245

First Author:	Prasad R
Year:	1997
Journal:	Oncogene
Title:	Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.
Volume:	15
Issue:	5
Pages:	549-60

•

Publication

33432228 | J:302194

First Author:	Rivas MA
Year:	2021
Journal:	Nat Immunol
Title:	Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Volume:	22
Issue:	2
Pages:	240-253

•

Publication

34502349 | J:340429

First Author:	Solich J
Year:	2021
Journal:	Int J Mol Sci
Title:	MicroRNA Let-7e in the Mouse Prefrontal Cortex Differentiates Restraint-Stress-Resilient Genotypes from Susceptible Genotype.
Volume:	22
Issue:	17

•

Publication

29367767 | J:261028

First Author:	Fantini D
Year:	2018
Journal:	Oncogene
Title:	A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer.
Volume:	37
Issue:	14
Pages:	1911-1925

•

Publication

31128216 | J:276347

First Author:	Fagan RJ
Year:	2019
Journal:	Cancer Lett
Title:	COMPASS Ascending: Emerging clues regarding the roles of MLL3/KMT2C and MLL2/KMT2D proteins in cancer.
Volume:	458

Pages:	56-65

•

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/keywordSearchResults.do;jsessionid=1A0263CC9ECB654E37EFA913B545E07A?searchOffset=300&searchTerm=Kmt2d

MouseMine

Search our database by keyword

Examples

Search results 301 to 324 out of 324 for Kmt2d

Categories

Hits by Pathway

Hits by Strain

Hits by Category