Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
|
Allele |
Name: |
transgene insertion IN103, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
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•
•
•
•
•
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Strain |
Attribute String: |
mutant stock, transgenic |
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•
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•
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•
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Publication |
First Author: |
Chen H |
Year: |
2000 |
Journal: |
Neuron |
Title: |
Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. |
Volume: |
25 |
Issue: |
1 |
Pages: |
43-56 |
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•
•
•
•
•
|
Publication |
First Author: |
Bagri A |
Year: |
2003 |
Journal: |
Cell |
Title: |
Stereotyped pruning of long hippocampal axon branches triggered by retraction inducers of the semaphorin family. |
Volume: |
113 |
Issue: |
3 |
Pages: |
285-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yaron A |
Year: |
2005 |
Journal: |
Neuron |
Title: |
Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins. |
Volume: |
45 |
Issue: |
4 |
Pages: |
513-23 |
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•
•
•
•
•
|
Publication |
First Author: |
Takahashi T |
Year: |
1999 |
Journal: |
Cell |
Title: |
Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. |
Volume: |
99 |
Issue: |
1 |
Pages: |
59-69 |
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•
•
•
•
•
|
Publication |
First Author: |
Goshima Y |
Year: |
2002 |
Journal: |
J Clin Invest |
Title: |
Semaphorins as signals for cell repulsion and invasion. |
Volume: |
109 |
Issue: |
8 |
Pages: |
993-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamura F |
Year: |
2000 |
Journal: |
J Neurobiol |
Title: |
Molecular basis of semaphorin-mediated axon guidance. |
Volume: |
44 |
Issue: |
2 |
Pages: |
219-29 |
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•
•
•
•
•
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Publication |
First Author: |
Lindholm T |
Year: |
2004 |
Journal: |
Neuroreport |
Title: |
Semaphorin and neuropilin expression in motoneurons after intraspinal motoneuron axotomy. |
Volume: |
15 |
Issue: |
4 |
Pages: |
649-54 |
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•
•
•
•
•
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Publication |
First Author: |
Steinbach K |
Year: |
2002 |
Journal: |
Exp Cell Res |
Title: |
Semaphorin 3E/collapsin-5 inhibits growing retinal axons. |
Volume: |
279 |
Issue: |
1 |
Pages: |
52-61 |
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•
•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
Semaphorins were first cloned as recognised mediators of cellular guidance, and consist of a large family of phylogenetically conserved secreted and transmembrane signalling proteins. Among the best-characterised vertebrate Semaphorins are the five secreted Class 3 members that contain an approximately 500 amino acid N-terminal Semaphorin domain, a C2 type immunoglobulin domain, and a highly basic C-terminal tail []. Two receptor families have been implicated in mediating the actions of class 3 semaphorins: the Neuropilins and Plexins. The nine known vertebrate Plexins are divided into four subfamilies (A through D) based on structure []. Several Plexins have been shown to interact directly with some class 4, 7 and V Semaphorins, but class 3 Semaphorins, however, do not appear to bind Plexins directly. Rather, the functional receptors for these Semaphorins are complexes of Neuropilins and A-type Plexins, with the former serving as the ligand-binding moiety and the latter the signal-transducing component [, ]. There are two Neuropilins (NP-1 and NP-2) that bind the five class 3 Semaphorins preferentially. In particular, Sema3A binds NP-1, whereas Sema3F utilises NP-2, while NP-1 and NP-2 heterodimers are thought to serve as functional receptors for Sema3C [].Semaphorin 4F may be involved in the injury response of intramedullary axotomized motoneurons []. |
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•
•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
Semaphorins were first cloned as recognised mediators of cellular guidance, and consist of a large family of phylogenetically conserved secreted and transmembrane signalling proteins. Among the best-characterised vertebrate Semaphorins are the five secreted Class 3 members that contain an approximately 500 amino acid N-terminal Semaphorin domain, a C2 type immunoglobulin domain, and a highly basic C-terminal tail []. Two receptor families have been implicated in mediating the actions of class 3 semaphorins: the Neuropilins and Plexins. The nine known vertebrate Plexins are divided into four subfamilies (A through D) based on structure []. Several Plexins have been shown to interact directly with some class 4, 7 and V Semaphorins, but class 3 Semaphorins, however, do not appear to bind Plexins directly. Rather, the functional receptors for these Semaphorins are complexes of Neuropilins and A-type Plexins, with the former serving as the ligand-binding moiety and the latter the signal-transducing component [, ]. There are two Neuropilins (NP-1 and NP-2), which bind the five class 3 Semaphorins preferentially. In particular, Sema3A binds NP-1, whereas Sema3F utilises NP-2, while NP-1 and NP-2 heterodimers are thought to serve as functional receptors for Sema3C [].Recent work suggests a possible role of Gallus gallus (Chicken) Sema3E/collapsin-5 in restricting growth of retinal ganglion cell axons to the optic fibre layer []. |
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•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Semaphorins were first cloned as recognised mediators of cellular guidance, and consist of a large family of phylogenetically conserved secreted and transmembrane signalling proteins. Among the best-characterised vertebrate Semaphorins are the five secreted Class 3 members that contain an approximately 500 amino acid N-terminal Semaphorin domain, a C2 type immunoglobulin domain, and a highly basic C-terminal tail []. Two receptor families have been implicated in mediating the actions of class 3 semaphorins: the Neuropilins and Plexins. The nine known vertebrate Plexins are divided into four subfamilies (A through D) based on structure []. Several Plexins have been shown to interact directly with some class 4, 7 and V Semaphorins, but class 3 Semaphorins, however, do not appear to bind Plexins directly. Rather, the functional receptors for these Semaphorins are complexes of Neuropilins and A-type Plexins, with the former serving as the ligand-binding moiety and the latter the signal-transducing component [, ]. There are two Neuropilins (NP-1 and NP-2) that bind the five class 3 Semaphorins preferentially. In particular, Sema3A binds NP-1, whereas Sema3F utilises NP-2, while NP-1 and NP-2 heterodimers are thought to serve as functional receptors for Sema3C [].Recent microarray studies have suggested a role for Sema 6C in dental mesenchyme-induced neurite repulsion []. |
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•
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Publication |
First Author: |
Yamauchi K |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
FGF8 signaling regulates growth of midbrain dopaminergic axons by inducing semaphorin 3F. |
Volume: |
29 |
Issue: |
13 |
Pages: |
4044-55 |
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•
•
•
•
•
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Publication |
First Author: |
Low LK |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex. |
Volume: |
105 |
Issue: |
23 |
Pages: |
8136-41 |
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•
•
•
•
•
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Publication |
First Author: |
Pozas E |
Year: |
2001 |
Journal: |
Mol Cell Neurosci |
Title: |
Age-dependent effects of secreted Semaphorins 3A, 3F, and 3E on developing hippocampal axons: in vitro effects and phenotype of Semaphorin 3A (-/-) mice. |
Volume: |
18 |
Issue: |
1 |
Pages: |
26-43 |
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•
•
•
•
•
|
Publication |
First Author: |
Mohan V |
Year: |
2018 |
Journal: |
Front Cell Neurosci |
Title: |
Neurocan Inhibits Semaphorin 3F Induced Dendritic Spine Remodeling Through NrCAM in Cortical Neurons. |
Volume: |
12 |
|
Pages: |
346 |
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•
•
•
•
•
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Publication |
First Author: |
Reuer T |
Year: |
2018 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Semaphorin 3F Modulates Corneal Lymphangiogenesis and Promotes Corneal Graft Survival. |
Volume: |
59 |
Issue: |
12 |
Pages: |
5277-5284 |
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•
•
•
•
•
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Publication |
First Author: |
Ziak J |
Year: |
2020 |
Journal: |
EMBO Rep |
Title: |
CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling. |
Volume: |
21 |
Issue: |
3 |
Pages: |
e48512 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
80
|
Fragment?: |
false |
|
•
•
•
•
•
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Publication |
First Author: |
Tamagnone L |
Year: |
1999 |
Journal: |
Cell |
Title: |
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. |
Volume: |
99 |
Issue: |
1 |
Pages: |
71-80 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
124
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
931
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
963
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
774
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
61
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
923
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
923
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
963
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
777
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
777
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
722
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
775
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
574
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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•
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