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Search results 501 to 561 out of 561 for Bub1

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Type Details Score
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
20057499 | J:186375
First Author: Niikura Y
Year: 2010
Journal: Cell Death Differ
Title: BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).
Volume: 17
Issue: 6
Pages: 1011-24
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UniProt Feature
UniProt Feature
Begin: 1
Description: Mitotic checkpoint serine/threonine-protein kinase BUB1
Type: chain
End: 1058
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Gene
171576 | Bub1b
Type: gene
Organism: rat
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Gene
608350 | BUB1B
Type: gene
Organism: dog, domestic
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Gene
453324 | BUB1B
Type: gene
Organism: chimpanzee
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Gene
537027 | BUB1B
Type: gene
Organism: cattle
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Gene
378922 | BUB1B
Type: gene
Organism: chicken
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Gene
567006 | bub1bb
Type: gene
Organism: zebrafish
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Gene
567931 | bub1ba
Type: gene
Organism: zebrafish
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Gene
100423079 | BUB1B
Type: gene
Organism: macaque, rhesus
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Gene
398234 | bub1.L
Type: gene
Organism: frog, African clawed
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Publication
17189386 | J:117796
First Author: Guo C
Year: 2006
Journal: Mol Cancer Res
Title: Bub1 up-regulation and hyperphosphorylation promote malignant transformation in SV40 tag-induced transgenic mouse models.
Volume: 4
Issue: 12
Pages: 957-69
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Protein
O08901
Organism: Mus musculus/domesticus
Length: 1058  
Fragment?: false
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Protein
A2APR8
Organism: Mus musculus/domesticus
Length: 1059  
Fragment?: false
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Protein
A0A8I4YXJ8
Organism: Mus musculus/domesticus
Length: 1058  
Fragment?: false
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UniProt Feature
UniProt Feature
Begin: 1
Description: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Type: chain
End: 1052
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Publication
9660858 | J:48710
First Author: Taylor SS
Year: 1998
Journal: J Cell Biol
Title: The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase.
Volume: 142
Issue: 1
Pages: 1-11
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Protein
Q9Z1S0
Organism: Mus musculus/domesticus
Length: 1052  
Fragment?: false
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Publication
9864354 | J:51901
First Author: Bernard P
Year: 1998
Journal: J Cell Biol
Title: Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis.
Volume: 143
Issue: 7
Pages: 1775-87
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Publication
16107724 | J:100551
First Author: Cowley DO
Year: 2005
Journal: Mol Cell Biol
Title: A dominant interfering Bub1 mutant is insufficient to induce or alter thymic tumorigenesis in vivo, even in a sensitized genetic background.
Volume: 25
Issue: 17
Pages: 7796-802
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Publication
14744753 | J:88094
First Author: Dai W
Year: 2004
Journal: Cancer Res
Title: Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency.
Volume: 64
Issue: 2
Pages: 440-5
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Publication
15208629 | J:91128
First Author: Baker DJ
Year: 2004
Journal: Nat Genet
Title: BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.
Volume: 36
Issue: 7
Pages: 744-9
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Publication
12925705 | J:85203
First Author: Weaver BA
Year: 2003
Journal: J Cell Biol
Title: Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss.
Volume: 162
Issue: 4
Pages: 551-63
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Publication
26832405 | -
First Author: Bokros M
Year: 2016
Journal: Cell Rep
Title: Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase.
Volume: 14
Issue: 5
Pages: 1074-1085
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Publication
17981135 | -
First Author: Kiyomitsu T
Year: 2007
Journal: Dev Cell
Title: Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1.
Volume: 13
Issue: 5
Pages: 663-76
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Publication
22187426 | -
First Author: Lee S
Year: 2012
Journal: J Biol Chem
Title: Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases.
Volume: 287
Issue: 8
Pages: 5988-6001
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Publication
12769845 | -
First Author: Kitagawa K
Year: 2003
Journal: Mol Cell
Title: Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint.
Volume: 11
Issue: 5
Pages: 1201-13
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Publication
10395177 | -
First Author: Yamaguchi K
Year: 1999
Journal: Cancer Lett
Title: Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines.
Volume: 139
Issue: 2
Pages: 183-7
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Publication
9521327 | -
First Author: Cahill DP
Year: 1998
Journal: Nature
Title: Mutations of mitotic checkpoint genes in human cancers.
Volume: 392
Issue: 6673
Pages: 300-3
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Publication
17369399 | -
First Author: Burton JL
Year: 2007
Journal: Genes Dev
Title: Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.
Volume: 21
Issue: 6
Pages: 655-67
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Publication
19503101 | -
First Author: Izumi H
Year: 2009
Journal: Oncogene
Title: BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells.
Volume: 28
Issue: 31
Pages: 2806-20
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Protein Domain
IPR015661 | Bub1/Mad3
Type: Family
Description: This represents the mitotic checkpoint serine/threonine-protein kinase Bub1. Saccharomyces cerevisiae Bub1 has a paralogue, Mad3, which is also included in this entry. Bub1 forms a complex with Mad1 and Bub3 that is crucial for preventing cell cycle progression into anaphase in the presence of spindle damage [], while Mad3 is a component of the spindle-assembly complex consisting of Mad2, Mad3, Bub3 and Cdc20 []. Mad3 contains a D-box and two KEN- boxes, which function together to mediate Cdc20-Mad3 interaction. Mad3 and an anaphase-promoting complex (APC) substrate, Hsl1, compete for Cdc20 binding in a D-box- and KEN-box-dependent manner [].Similar to its yeast homologues, human Bub1 is a critical component of the mitotic checkpoint that delays the onset of anaphase until all chromosomes have established bipolar attachment to the microtubules. In interphase cells it localises to centrosomes and suppresses centrosome amplification via regulating Plk1 activity []. Mutations in the human Bub1 gene have been linked to cancers [, ].
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Protein Domain
IPR013212 | Mad3/Bub1_I
Type: Domain
Description: Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of Bub1 and Mad3 to Cdc20 [].
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Publication
10704439 | -
First Author: Hardwick KG
Year: 2000
Journal: J Cell Biol
Title: MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p.
Volume: 148
Issue: 5
Pages: 871-82
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Protein Domain
IPR012572 | Mad3/Bub1_II
Type: Domain
Description: This domain is found in checkpoint proteins which are involved in cell division. This region has been shown to be necessary and sufficient for the binding of Mad3 to Bub3 in Saccharomyces cerevisiae. This domain is present in Bub1 which also binds Bub3 [].
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Protein
Q8C2J4
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: true
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Publication
24436071 | J:319967
First Author: Rakkaa T
Year: 2014
Journal: Chromosome Res
Title: CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis.
Volume: 22
Issue: 3
Pages: 267-76
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Publication
22493223 | J:314383
First Author: Kim S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting.
Volume: 109
Issue: 17
Pages: 6549-54
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Publication
10445022 | J:56701
First Author: Lee H
Year: 1999
Journal: Mol Cell
Title: Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.
Volume: 4
Issue: 1
Pages: 1-10
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Protein
Q8K2E5
Organism: Mus musculus/domesticus
Length: 1052  
Fragment?: false
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Protein
Q3UZD6
Organism: Mus musculus/domesticus
Length: 1052  
Fragment?: false
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Publication
14730319 | J:88148
First Author: Kitajima TS
Year: 2004
Journal: Nature
Title: The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis.
Volume: 427
Issue: 6974
Pages: 510-7
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Publication
18987869 | -
First Author: Rivera T
Year: 2009
Journal: Chromosoma
Title: Shugoshin regulates cohesion by driving relocalization of PP2A in Xenopus extracts.
Volume: 118
Issue: 2
Pages: 223-33
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Publication
16687935 | -
First Author: Suzuki H
Year: 2006
Journal: Cell Cycle
Title: Human Shugoshin mediates kinetochore-driven formation of kinetochore microtubules.
Volume: 5
Issue: 10
Pages: 1094-101
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Publication
17322402 | -
First Author: Kawashima SA
Year: 2007
Journal: Genes Dev
Title: Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres.
Volume: 21
Issue: 4
Pages: 420-35
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Protein Domain
IPR011515 | Shugoshin_C
Type: Domain
Description: This entry represents the C-terminal domain of Shugoshin (Sgo1) kinetochore-attachment proteins. Shugoshin has a conserved coiled-coil N-terminal domain and a highly conserved C-terminal basic region (). Shugoshin is a crucial target of Bub1 kinase that plays a central role in chromosome cohesion during mitosis and meiosis divisions by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms [, ]. Shugoshin is thought to act by protecting Rec8 and Rad21 at the centromeres from separase degradation during anaphase I (during meiosis) so that sister chromatids remain tethered []. Shugoshin also acts as a spindle checkpoint component required for sensing tension between sister chromatids during mitosis, its degradation when they separate preventing cell cycle arrest and chromosome loss in anaphase, a time when sister chromatids are no longer under tension. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly []. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process [].
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Protein Domain
IPR011516 | Shugoshin_N
Type: Domain
Description: This entry represents the N-terminal domain of Shugoshin (Sgo1) kinetochore-attachment proteins. Shugoshin has this conserved coiled-coil N-terminal domain and a highly conserved C-terminal basic region ().Shugoshin is a crucial target of Bub1 kinase that plays a central role in chromosome cohesion during mitosis and meiosis divisions by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms [, ]. Shugoshin is thought to act by protecting Rec8 and Rad21 at the centromeres from separase degradation during anaphase I (during meiosis) so that sister chromatids remain tethered []. Shugoshin also acts as a spindle checkpoint component required for sensing tension between sister chromatids during mitosis, its degradation when they separate preventing cell cycle arrest and chromosome loss in anaphase, a time when sister chromatids are no longer under tension. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly []. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process [].
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Protein
Q8K1K8
Organism: Mus musculus/domesticus
Length: 1059  
Fragment?: false
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Publication
30856164 | J:273098
First Author: Peterka M
Year: 2019
Journal: PLoS Genet
Title: Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice.
Volume: 15
Issue: 3
Pages: e1008050
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Publication
25628462 | J:260326
First Author: Bowman BM
Year: 2015
Journal: Sci Signal
Title: Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer.
Volume: 8
Issue: 361
Pages: ra9
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Publication
11250674 | J:67496
First Author: McKeon F
Year: 1999
Journal: Breast Cancer Res
Title: Killing the umpire: cooperative defects in mitotic checkpoint and BRCA2 genes on the road to transformation.
Volume: 1
Issue: 1
Pages: 8-10
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Publication
9790499 | J:50238
First Author: Ouyang B
Year: 1998
Journal: Cell Growth Differ
Title: Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation.
Volume: 9
Issue: 10
Pages: 877-85
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Protein
Q9CXH7
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Publication
31478449 | J:296550
First Author: Zhou CJ
Year: 2019
Journal: Cell Cycle
Title: Loss of CENPF leads to developmental failure in mouse embryos.
Volume: 18
Issue: 20
Pages: 2784-2799
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Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
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Publication
11076861 | J:68324
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
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Publication
16141073 | -
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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