Tetratricopeptide repeat domain proteins 39A, 39B and 39C are eukaryotic proteins of unknown function. This entry includes TTC39A.In humans, tetratricopeptide repeat protein 39A (TTC39A), also known as differentially expressed in MCF7 with estradiol protein 6 (DEME6), is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive [].
This entry represents a family of proteins conserved from fungi to humans, including fungal Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some characterised proteins. Members of this family carry a tetratricopeptide repeat () at their C terminus. In Saccharomyces cerevisiae, Iml2 and its paralogue-YKR018C are included in this entry. Iml2 localises to the cytoplasm and nucleus [], and its expression is increased in response to DNA replication stress []. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress [].In humans TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive []. TTC39B has been linked to lipid metabolism [, ].
