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Search results 201 to 248 out of 248 for Faap100

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0.044s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Strain
MGI:6354767 | C57BL/6J-Faap100<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Protein
P50652
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
Q3UI88
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: true
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Protein
A0A1D5RLC1
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: true
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Protein
E0CYQ7
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: true
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Protein
A0A1Y7VKS5
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
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Protein
E0CXC4
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
E0CYI2
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
E9QAE8
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
F7DEE2
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
E0CYC3
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Protein
Q3V2X6
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Protein
Q8CBR3
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
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Protein Domain
IPR000686 | FANCC
Type: Family
Description: Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].This entry represents FANCC [].
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Protein Domain
IPR003516 | FANCA
Type: Family
Description: Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].This entry represents FANCA [].
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Protein Domain
IPR031729 | Fanconi_A_N
Type: Domain
Description: Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].This entry represents the N-terminal domain of FANCA.
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Protein Domain
IPR039685 | FANCE
Type: Family
Description: Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].The FA group E protein (FANCE) has an important role in DNA repair, functioning as the FANCD2-binding protein in the FA core complex [].
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Protein
Q9JL70
Organism: Mus musculus/domesticus
Length: 1439  
Fragment?: false
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Protein
B2RWU3
Organism: Mus musculus/domesticus
Length: 1439  
Fragment?: false
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Protein
D3Z6Y5
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
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Protein
F7CK17
Organism: Mus musculus/domesticus
Length: 771  
Fragment?: true
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Publication
17938197 | -
First Author: Alpi A
Year: 2007
Journal: Mol Cell Biol
Title: UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.
Volume: 27
Issue: 24
Pages: 8421-30
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Publication
12973351 | J:86047
First Author: Meetei AR
Year: 2003
Journal: Nat Genet
Title: A novel ubiquitin ligase is deficient in Fanconi anemia.
Volume: 35
Issue: 2
Pages: 165-70
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Publication
15502827 | -
First Author: Meetei AR
Year: 2004
Journal: Nat Genet
Title: X-linked inheritance of Fanconi anemia complementation group B.
Volume: 36
Issue: 11
Pages: 1219-24
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Publication
22287633 | -
First Author: Sato K
Year: 2012
Journal: Nucleic Acids Res
Title: DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI.
Volume: 40
Issue: 10
Pages: 4553-61
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Protein Domain
IPR026985 | FAAP24
Type: Family
Description: Fanconi anemia-associated protein of 24kDa (FAAP24) plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. It regulates FANCD2 monoubiquitination upon DNA damage. When repressed, it induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents. It targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA [].Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].
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Protein Domain
IPR026848 | Fancl
Type: Family
Description: Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].FANCL is an ubiquitin ligase that mediates monoubiquitination of FANCD2, a key step in the repair of interstrand DNA crosslinks (ICLs) in the Fanconi anemia (FA) pathway [, ]. In humans, defects in FANCL are the cause of Fanconi anemia complementation group L (FANCL). FANCL is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair [, ].
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Protein Domain
IPR035428 | FANCF
Type: Family
Description: Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].Fanconi anemia group F protein (FANCF) is a component of the FA core complex [, ]. FANCF regulates its own expression by methylation at both mRNA and protein levels. Methylation-induced inactivation of FANCF has an important role on the occurrence of ovarian cancers by disrupting the FA-BRCA pathway [].This entry also includes homologues from plants.
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Protein
B8JJD8
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
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Protein
B8JJD5
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Protein
B8JJD2
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: true
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Protein
F7DAL6
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
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Protein
B8JJD1
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
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Protein
B8JJD6
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
Q3UY28
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: true
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Protein
B8JJD3
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Protein
A0A3B2W3J1
Organism: Mus musculus/domesticus
Length: 355  
Fragment?: true
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Protein
B8JJD7
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
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Protein
Q8R3Z2
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: false
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Publication
17308347 | -
First Author: Nookala RK
Year: 2007
Journal: Nucleic Acids Res
Title: Insights into Fanconi Anaemia from the structure of human FANCE.
Volume: 35
Issue: 5
Pages: 1638-48
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Protein
E9Q5Z5
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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Publication
17289582 | J:320165
First Author: Ciccia A
Year: 2007
Journal: Mol Cell
Title: Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.
Volume: 25
Issue: 3
Pages: 331-43
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Publication
17768402 | -
First Author: Wang W
Year: 2007
Journal: Nat Rev Genet
Title: Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.
Volume: 8
Issue: 10
Pages: 735-48
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Publication
16418574 | -
First Author: Wang Z
Year: 2006
Journal: Cancer Biol Ther
Title: Promoter hypermethylation of FANCF plays an important role in the occurrence of ovarian cancer through disrupting Fanconi anemia-BRCA pathway.
Volume: 5
Issue: 3
Pages: 256-60
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Publication
16357213 | -
First Author: Kennedy RD
Year: 2005
Journal: Genes Dev
Title: The Fanconi Anemia/BRCA pathway: new faces in the crowd.
Volume: 19
Issue: 24
Pages: 2925-40
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Protein
Q8BHL6
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
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Protein
Q9CR14
Organism: Mus musculus/domesticus
Length: 375  
Fragment?: false
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Protein
F6Q7G3
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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