Brme1 (also known as Meiok21) is a component of meiotic recombination bridges involved in meiotic double-strand break repair [, ]. The C-terminal domain of Brme1 physically interacts with the N-terminal domain of HSF2BP []. BRME1 facilitates the loading of RAD51 and DMC1 recombinases onto DSBs (DNA double-strand breaks) through interaction with MEILB2/HSF2BP and replacing ssDNA binding proteins []. Brme1 is highly expressed in mice testes and fetal ovaries. Knockout of Brme1 results in male mice infertility [].
