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Search results 101 to 104 out of 104 for Nalf1

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Type Details Score
Protein Domain
IPR028823 | NALCN
Type: Family
Description: Sodium leak channel non-selective protein (NALCN) was first described as a voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions [], however, it was recently reported to be selective only for monovalent cations and to be blocked by extracellular divalent cations []. Coexpression of NALCN, UNC79, UNC80, and NALF1 results in voltage-dependent NALCN currents [, ]. It is responsible for the background sodium ion leak current in neurons and controls neuronal excitability. It is activated either by neuropeptides substance P or neurotensin []. NALCN is required for normal respiratory rhythm and neonatal survival [].
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Publication
32494638 | -
First Author: Chua HC
Year: 2020
Journal: Sci Adv
Title: The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium.
Volume: 6
Issue: 17
Pages: eaaz3154
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Protein
Q8BXR5
Organism: Mus musculus/domesticus
Length: 1738  
Fragment?: false
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Protein
E9QLE4
Organism: Mus musculus/domesticus
Length: 1739  
Fragment?: false
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