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Search results 701 to 800 out of 891 for Nfatc1

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Type Details Score
Allele
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1, Bin Zhou
Allele Type: Targeted
Attribute String: Recombinase
Allele
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1.1, Bin Zhou
Allele Type: Targeted
Attribute String: Recombinase
Allele
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; endonuclease-mediated mutation 1, Bin Zhou
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
Allele
Name: transgene insertion 1, Bin Zhou
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: transgene insertion 1, Gerald R Crabtree
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
Genotype
Symbol: Nfatc1/Nfatc1<+>
Background: involves: C57BL/6 * ICR
Zygosity: ht
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
Publication
First Author: Launay P
Year: 2002
Journal: Cell
Title: TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization.
Volume: 109
Issue: 3
Pages: 397-407
Publication  
First Author: Mathar I
Year: 2014
Journal: Handb Exp Pharmacol
Title: TRPM4.
Volume: 222
Pages: 461-87
Publication  
First Author: Kruse M
Year: 2014
Journal: Curr Opin Pharmacol
Title: TRPM4 channels in the cardiovascular system.
Volume: 15
Pages: 68-73
Publication
First Author: Earley S
Year: 2004
Journal: Circ Res
Title: Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries.
Volume: 95
Issue: 9
Pages: 922-9
Publication
First Author: Weber KS
Year: 2010
Journal: J Immunol
Title: Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization.
Volume: 185
Issue: 5
Pages: 2836-46
Protein Domain
Type: Family
Description: The TRPM subfamily of mammalian TRP channels includes TRPM4, which is a Ca2+-activated nonselective cation channel that mediates cell membrane depolarisation []. Unlike TRPM5, its closest relative in the transient receptor potential family, TRPM4 proteins are widely expressed in the body []. They are abundant expressed in cardiac cells and are involved in several aspects of cardiac rhythmicity, including cardiac conduction, pace making and action-potential repolarisation []. They are also expressed in cerebral arteries, where they play a role in myogenic vasoconstriction []. TRPM4 proteins also affect T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signalling and NFATC1 localisation [].
Publication
First Author: Tripathi P
Year: 2014
Journal: Oncogene
Title: Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms.
Volume: 33
Issue: 14
Pages: 1840-9
Genotype
Symbol: Krit1/Krit1 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ift88/Ift88 Nfatc1/Nfatc1<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ift88/Ift88<+> Nfatc1/Nfatc1<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Allele
Name: transgene insertion 96, Bin Zhou
Allele Type: Transgenic
Attribute String: Transactivator
Genotype
Symbol: Kdr/Kdr Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ccm2/Ccm2 Nfatc1/Nfatc1<+>
Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Adgrg6/Adgrg6 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nfatc1/Nfatc1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * ICR
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Dhh/Dhh Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Dhh/Dhh<+> Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Jag1/Jag1 Nfatc1/Nfatc1<+>
Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Huk DJ
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification.
Volume: 36
Issue: 2
Pages: 328-38
Genotype
Symbol: Tbx20/Tbx20 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nfatc1/Nfatc1<+> Smarca4/Smarca4
Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Smarca4/Smarca4 Tg(Nfat1c-cre)1Bz/?
Background: involves: 129S2/SvPas
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Pdcd10/Pdcd10 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nfatc1/Nfatc1<+> Sema6d/Sema6d
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/Sv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Dzip1/Dzip1 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Krit1/Krit1 Map3k3/Map3k3<+> Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Dzip1/Dzip1<+> Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+> Npr3/Npr3<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * ICR
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Dll4/Dll4 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Notch1/Notch1 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Nfatc1/Nfatc1<+> Tek/Tek
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Efnb2/Efnb2 Nfatc1/Nfatc1<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Sox17/Sox17 Tg(Nfat1c-cre)1Bz/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Hayashi H
Year: 2008
Journal: FEBS Lett
Title: The role of Mac-1 (CD11b/CD18) in osteoclast differentiation induced by receptor activator of nuclear factor-kappaB ligand.
Volume: 582
Issue: 21-22
Pages: 3243-8
Publication
First Author: Okamura H
Year: 2013
Journal: FEBS Lett
Title: Protein phosphatase 2A Cα is involved in osteoclastogenesis by regulating RANKL and OPG expression in osteoblasts.
Volume: 587
Issue: 1
Pages: 48-53
Protein
Organism: Mus musculus/domesticus
Length: 1213  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1066  
Fragment?: false
Publication        
First Author: Qu X
Year: 2016
Title: A Novel Role for Endocardium in Perinatal Valve Development: Lessons Learned from Tissue-Specific Gene Deletion of the Tie1 Receptor Tyrosine Kinase
Genotype
Symbol: Sox7/Sox7 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rag2/Rag2 Tg(EmuSR-tTa)83Bop/? Tg(tetO-Nfatct1*)1Grc/?
Background: involves: 129S/SvEv * C57BL/6J * CBA/J * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Nfatc1/Nfatc1<+> Smarca4/Smarca4
Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Map3k3/Map3k3 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Bmp2/Bmp2 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Klf2/Klf2 Tg(Nfat1c-cre)1Bz/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Wang D
Year: 2008
Journal: Mol Immunol
Title: The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT.
Volume: 45
Issue: 15
Pages: 3902-8
Publication
First Author: Fukushima H
Year: 2008
Journal: Mol Cell Biol
Title: The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis.
Volume: 28
Issue: 20
Pages: 6402-12
Publication
First Author: Patterson AR
Year: 2018
Journal: Nat Commun
Title: Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology.
Volume: 9
Issue: 1
Pages: 430
Publication
First Author: Zhao C
Year: 2006
Journal: Cell Metab
Title: Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis.
Volume: 4
Issue: 2
Pages: 111-21
Publication
First Author: Nishikawa K
Year: 2021
Journal: EMBO Rep
Title: Osteoclasts adapt to physioxia perturbation through DNA demethylation.
Volume: 22
Issue: 12
Pages: e53035
Publication
First Author: Wang X
Year: 2015
Journal: Cell Metab
Title: A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption.
Volume: 22
Issue: 5
Pages: 811-24
Publication
First Author: Lu P
Year: 2014
Journal: J Exp Med
Title: Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection.
Volume: 211
Issue: 3
Pages: 515-27
Publication
First Author: D'Arcy CE
Year: 2014
Journal: Hum Mol Genet
Title: Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy.
Volume: 23
Issue: 3
Pages: 618-36
Publication
First Author: Jellusova J
Year: 2010
Journal: J Immunol
Title: Siglec-G regulates B1 cell survival and selection.
Volume: 185
Issue: 6
Pages: 3277-84
Publication
First Author: Tsuji-Takechi K
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development.
Volume: 109
Issue: 7
Pages: 2561-6
Publication
First Author: Bour-Jordan H
Year: 2003
Journal: Nat Immunol
Title: CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
Volume: 4
Issue: 2
Pages: 182-8
Publication
First Author: Tomassian T
Year: 2011
Journal: J Immunol
Title: Caveolin-1 orchestrates TCR synaptic polarity, signal specificity, and function in CD8 T cells.
Volume: 187
Issue: 6
Pages: 2993-3002
Publication  
First Author: Huynh H
Year: 2018
Journal: Commun Biol
Title: mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1.
Volume: 1
Pages: 29
Publication
First Author: Nurieva RI
Year: 2010
Journal: Immunity
Title: The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.
Volume: 32
Issue: 5
Pages: 670-80
Publication
First Author: Alam MS
Year: 2014
Journal: J Exp Med
Title: Counter-regulation of T cell effector function by differentially activated p38.
Volume: 211
Issue: 6
Pages: 1257-70
Publication  
First Author: Guo M
Year: 2016
Journal: Sci Rep
Title: Cyclophilin A (CypA) Plays Dual Roles in Regulation of Bone Anabolism and Resorption.
Volume: 6
Pages: 22378
Publication
First Author: Wang L
Year: 2016
Journal: Science
Title: Foxc1 reinforces quiescence in self-renewing hair follicle stem cells.
Volume: 351
Issue: 6273
Pages: 613-7
Publication
First Author: Li C
Year: 2015
Journal: EMBO Mol Med
Title: ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.
Volume: 7
Issue: 6
Pages: 754-69
Publication  
First Author: Boraschi-Diaz I
Year: 2018
Journal: Bone
Title: Collagen type I degradation fragments act through the collagen receptor LAIR-1 to provide a negative feedback for osteoclast formation.
Volume: 117
Pages: 23-30
Publication
First Author: Zhang Y
Year: 2009
Journal: J Biol Chem
Title: MKP-1 is necessary for T cell activation and function.
Volume: 284
Issue: 45
Pages: 30815-24
Publication
First Author: Saita Y
Year: 2007
Journal: J Biol Chem
Title: Lack of Schnurri-2 expression associates with reduced bone remodeling and osteopenia.
Volume: 282
Issue: 17
Pages: 12907-15
Publication
First Author: Masle-Farquhar E
Year: 2022
Journal: Cell Rep
Title: Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint.
Volume: 38
Issue: 3
Pages: 110259
Publication
First Author: Koo JH
Year: 2017
Journal: J Clin Invest
Title: Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism.
Volume: 127
Issue: 10
Pages: 3845-3860
Publication
First Author: Goettsch C
Year: 2013
Journal: J Clin Invest
Title: NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis.
Volume: 123
Issue: 11
Pages: 4731-8
Publication  
First Author: Park SJ
Year: 2016
Journal: Sci Rep
Title: Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation.
Volume: 6
Pages: 26186
Publication
First Author: Choi HK
Year: 2013
Journal: Cell Res
Title: Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis.
Volume: 23
Issue: 4
Pages: 524-36
Publication
First Author: Kim K
Year: 2007
Journal: Blood
Title: MafB negatively regulates RANKL-mediated osteoclast differentiation.
Volume: 109
Issue: 8
Pages: 3253-9
Publication
First Author: Liu H
Year: 2015
Journal: Mol Cell
Title: The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.
Volume: 59
Issue: 5
Pages: 840-9
Publication  
First Author: Wang L
Year: 2015
Journal: Sci Rep
Title: Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos.
Volume: 5
Pages: 17517
Publication
First Author: Kohara Y
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Knockdown of Lrp1 in RAW264 cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions in vitro.
Volume: 523
Issue: 4
Pages: 961-965
Publication
First Author: Omata Y
Year: 2015
Journal: J Bone Miner Res
Title: Genomewide comprehensive analysis reveals critical cooperation between Smad and c-Fos in RANKL-induced osteoclastogenesis.
Volume: 30
Issue: 5
Pages: 869-77
Publication
First Author: Zhou Q
Year: 2021
Journal: J Invest Dermatol
Title: Phenformin Promotes Keratinocyte Differentiation via the Calcineurin/NFAT Pathway.
Volume: 141
Issue: 1
Pages: 152-163
Publication
First Author: Kazenwadel J
Year: 2023
Journal: Nature
Title: A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature.
Volume: 614
Issue: 7947
Pages: 343-348
Publication
First Author: Lu P
Year: 2022
Journal: Nat Commun
Title: A SOX17-PDGFB signaling axis regulates aortic root development.
Volume: 13
Issue: 1
Pages: 4065
Genotype
Symbol: Kdr/Kdr Nfatc1/Nfatc1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Smarca4/Smarca4 Nfatc1/Nfatc1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Creld1/Creld1 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Hand2/Hand2 Nfatc1/Nfatc1<+>
Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Kim HJ
Year: 2012
Journal: J Cell Biol
Title: Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival.
Volume: 199
Issue: 7
Pages: 1145-58
Publication
First Author: Park MY
Year: 2017
Journal: Sci Rep
Title: FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2.
Volume: 7
Issue: 1
Pages: 15575
Publication
First Author: Kim T
Year: 2009
Journal: J Biol Chem
Title: Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation.
Volume: 284
Issue: 22
Pages: 15308-16
Publication  
First Author: Ramaswamy G
Year: 2017
Journal: Sci Rep
Title: Gsα Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and β-Catenin Pathways.
Volume: 7
Pages: 45140
Publication
First Author: Zhu G
Year: 2022
Journal: Int J Biol Sci
Title: Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis.
Volume: 18
Issue: 14
Pages: 5522-5538
Publication
First Author: Miyauchi Y
Year: 2010
Journal: J Exp Med
Title: The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.
Volume: 207
Issue: 4
Pages: 751-62
Publication
First Author: Kanady JD
Year: 2015
Journal: Dev Biol
Title: Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling.
Volume: 405
Issue: 1
Pages: 33-46