Type |
Details |
Score |
Allele |
Name: |
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1, Bin Zhou |
Allele Type: |
Targeted |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1.1, Bin Zhou |
Allele Type: |
Targeted |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; endonuclease-mediated mutation 1, Bin Zhou |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Bin Zhou |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Gerald R Crabtree |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nfatc1/Nfatc1<+> |
Background: |
involves: C57BL/6 * ICR |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
128
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Launay P |
Year: |
2002 |
Journal: |
Cell |
Title: |
TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. |
Volume: |
109 |
Issue: |
3 |
Pages: |
397-407 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mathar I |
Year: |
2014 |
Journal: |
Handb Exp Pharmacol |
Title: |
TRPM4. |
Volume: |
222 |
|
Pages: |
461-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kruse M |
Year: |
2014 |
Journal: |
Curr Opin Pharmacol |
Title: |
TRPM4 channels in the cardiovascular system. |
Volume: |
15 |
|
Pages: |
68-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Earley S |
Year: |
2004 |
Journal: |
Circ Res |
Title: |
Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. |
Volume: |
95 |
Issue: |
9 |
Pages: |
922-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weber KS |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization. |
Volume: |
185 |
Issue: |
5 |
Pages: |
2836-46 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The TRPM subfamily of mammalian TRP channels includes TRPM4, which is a Ca2+-activated nonselective cation channel that mediates cell membrane depolarisation []. Unlike TRPM5, its closest relative in the transient receptor potential family, TRPM4 proteins are widely expressed in the body []. They are abundant expressed in cardiac cells and are involved in several aspects of cardiac rhythmicity, including cardiac conduction, pace making and action-potential repolarisation []. They are also expressed in cerebral arteries, where they play a role in myogenic vasoconstriction []. TRPM4 proteins also affect T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signalling and NFATC1 localisation []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Tripathi P |
Year: |
2014 |
Journal: |
Oncogene |
Title: |
Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms. |
Volume: |
33 |
Issue: |
14 |
Pages: |
1840-9 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Krit1/Krit1 Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ift88/Ift88 Nfatc1/Nfatc1<+> |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ift88/Ift88<+> Nfatc1/Nfatc1<+> |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 96, Bin Zhou |
Allele Type: |
Transgenic |
Attribute String: |
Transactivator |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Kdr/Kdr Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ccm2/Ccm2 Nfatc1/Nfatc1<+> |
Background: |
involves: 129 * 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Adgrg6/Adgrg6 Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nfatc1/Nfatc1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * ICR |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dhh/Dhh Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dhh/Dhh<+> Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Jag1/Jag1 Nfatc1/Nfatc1<+> |
Background: |
involves: 129 * 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Huk DJ |
Year: |
2016 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification. |
Volume: |
36 |
Issue: |
2 |
Pages: |
328-38 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tbx20/Tbx20 Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Black Swiss |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nfatc1/Nfatc1<+> Smarca4/Smarca4 |
Background: |
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Smarca4/Smarca4 Tg(Nfat1c-cre)1Bz/? |
Background: |
involves: 129S2/SvPas |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Pdcd10/Pdcd10 Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nfatc1/Nfatc1<+> Sema6d/Sema6d |
Background: |
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/Sv * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dzip1/Dzip1 Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Krit1/Krit1 Map3k3/Map3k3<+> Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl * C57BL/6NTac |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dzip1/Dzip1<+> Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+> Npr3/Npr3<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * ICR |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dll4/Dll4 Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Notch1/Notch1 Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nfatc1/Nfatc1<+> Tek/Tek |
Background: |
involves: 129 * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Efnb2/Efnb2 Nfatc1/Nfatc1<+> |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Sox17/Sox17 Tg(Nfat1c-cre)1Bz/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Hayashi H |
Year: |
2008 |
Journal: |
FEBS Lett |
Title: |
The role of Mac-1 (CD11b/CD18) in osteoclast differentiation induced by receptor activator of nuclear factor-kappaB ligand. |
Volume: |
582 |
Issue: |
21-22 |
Pages: |
3243-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okamura H |
Year: |
2013 |
Journal: |
FEBS Lett |
Title: |
Protein phosphatase 2A Cα is involved in osteoclastogenesis by regulating RANKL and OPG expression in osteoblasts. |
Volume: |
587 |
Issue: |
1 |
Pages: |
48-53 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1213
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1066
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Qu X |
Year: |
2016 |
|
Title: |
A Novel Role for Endocardium in Perinatal Valve Development: Lessons Learned from Tissue-Specific Gene Deletion of the Tie1 Receptor Tyrosine Kinase |
|
|
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Sox7/Sox7 Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rag2/Rag2 Tg(EmuSR-tTa)83Bop/? Tg(tetO-Nfatct1*)1Grc/? |
Background: |
involves: 129S/SvEv * C57BL/6J * CBA/J * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nfatc1/Nfatc1<+> Smarca4/Smarca4 |
Background: |
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Map3k3/Map3k3 Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Bmp2/Bmp2 Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Klf2/Klf2 Tg(Nfat1c-cre)1Bz/? |
Background: |
involves: C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6NCrl |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang D |
Year: |
2008 |
Journal: |
Mol Immunol |
Title: |
The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT. |
Volume: |
45 |
Issue: |
15 |
Pages: |
3902-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukushima H |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis. |
Volume: |
28 |
Issue: |
20 |
Pages: |
6402-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patterson AR |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology. |
Volume: |
9 |
Issue: |
1 |
Pages: |
430 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao C |
Year: |
2006 |
Journal: |
Cell Metab |
Title: |
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. |
Volume: |
4 |
Issue: |
2 |
Pages: |
111-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishikawa K |
Year: |
2021 |
Journal: |
EMBO Rep |
Title: |
Osteoclasts adapt to physioxia perturbation through DNA demethylation. |
Volume: |
22 |
Issue: |
12 |
Pages: |
e53035 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang X |
Year: |
2015 |
Journal: |
Cell Metab |
Title: |
A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption. |
Volume: |
22 |
Issue: |
5 |
Pages: |
811-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu P |
Year: |
2014 |
Journal: |
J Exp Med |
Title: |
Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection. |
Volume: |
211 |
Issue: |
3 |
Pages: |
515-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
D'Arcy CE |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy. |
Volume: |
23 |
Issue: |
3 |
Pages: |
618-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jellusova J |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Siglec-G regulates B1 cell survival and selection. |
Volume: |
185 |
Issue: |
6 |
Pages: |
3277-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsuji-Takechi K |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development. |
Volume: |
109 |
Issue: |
7 |
Pages: |
2561-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bour-Jordan H |
Year: |
2003 |
Journal: |
Nat Immunol |
Title: |
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. |
Volume: |
4 |
Issue: |
2 |
Pages: |
182-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tomassian T |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Caveolin-1 orchestrates TCR synaptic polarity, signal specificity, and function in CD8 T cells. |
Volume: |
187 |
Issue: |
6 |
Pages: |
2993-3002 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huynh H |
Year: |
2018 |
Journal: |
Commun Biol |
Title: |
mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1. |
Volume: |
1 |
|
Pages: |
29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nurieva RI |
Year: |
2010 |
Journal: |
Immunity |
Title: |
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. |
Volume: |
32 |
Issue: |
5 |
Pages: |
670-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alam MS |
Year: |
2014 |
Journal: |
J Exp Med |
Title: |
Counter-regulation of T cell effector function by differentially activated p38. |
Volume: |
211 |
Issue: |
6 |
Pages: |
1257-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo M |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Cyclophilin A (CypA) Plays Dual Roles in Regulation of Bone Anabolism and Resorption. |
Volume: |
6 |
|
Pages: |
22378 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang L |
Year: |
2016 |
Journal: |
Science |
Title: |
Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. |
Volume: |
351 |
Issue: |
6273 |
Pages: |
613-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li C |
Year: |
2015 |
Journal: |
EMBO Mol Med |
Title: |
ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy. |
Volume: |
7 |
Issue: |
6 |
Pages: |
754-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boraschi-Diaz I |
Year: |
2018 |
Journal: |
Bone |
Title: |
Collagen type I degradation fragments act through the collagen receptor LAIR-1 to provide a negative feedback for osteoclast formation. |
Volume: |
117 |
|
Pages: |
23-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
MKP-1 is necessary for T cell activation and function. |
Volume: |
284 |
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45 |
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30815-24 |
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•
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Publication |
First Author: |
Saita Y |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Lack of Schnurri-2 expression associates with reduced bone remodeling and osteopenia. |
Volume: |
282 |
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17 |
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12907-15 |
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Publication |
First Author: |
Masle-Farquhar E |
Year: |
2022 |
Journal: |
Cell Rep |
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Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint. |
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38 |
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3 |
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110259 |
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Publication |
First Author: |
Koo JH |
Year: |
2017 |
Journal: |
J Clin Invest |
Title: |
Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism. |
Volume: |
127 |
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10 |
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3845-3860 |
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Publication |
First Author: |
Goettsch C |
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2013 |
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J Clin Invest |
Title: |
NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis. |
Volume: |
123 |
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11 |
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4731-8 |
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Publication |
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Park SJ |
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2016 |
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Sci Rep |
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Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation. |
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6 |
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26186 |
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Publication |
First Author: |
Choi HK |
Year: |
2013 |
Journal: |
Cell Res |
Title: |
Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. |
Volume: |
23 |
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4 |
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524-36 |
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Publication |
First Author: |
Kim K |
Year: |
2007 |
Journal: |
Blood |
Title: |
MafB negatively regulates RANKL-mediated osteoclast differentiation. |
Volume: |
109 |
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8 |
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3253-9 |
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Publication |
First Author: |
Liu H |
Year: |
2015 |
Journal: |
Mol Cell |
Title: |
The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells. |
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59 |
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5 |
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840-9 |
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First Author: |
Wang L |
Year: |
2015 |
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Sci Rep |
Title: |
Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos. |
Volume: |
5 |
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17517 |
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Kohara Y |
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2020 |
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Biochem Biophys Res Commun |
Title: |
Knockdown of Lrp1 in RAW264 cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions in vitro. |
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523 |
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4 |
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961-965 |
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Omata Y |
Year: |
2015 |
Journal: |
J Bone Miner Res |
Title: |
Genomewide comprehensive analysis reveals critical cooperation between Smad and c-Fos in RANKL-induced osteoclastogenesis. |
Volume: |
30 |
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5 |
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Zhou Q |
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2021 |
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J Invest Dermatol |
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Phenformin Promotes Keratinocyte Differentiation via the Calcineurin/NFAT Pathway. |
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141 |
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1 |
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2023 |
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Nature |
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A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature. |
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614 |
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2022 |
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Nat Commun |
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A SOX17-PDGFB signaling axis regulates aortic root development. |
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13 |
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1 |
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•
•
•
•
•
|
Genotype |
Symbol: |
Kdr/Kdr Nfatc1/Nfatc1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Smarca4/Smarca4 Nfatc1/Nfatc1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Creld1/Creld1 Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Hand2/Hand2 Nfatc1/Nfatc1<+> |
Background: |
involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim HJ |
Year: |
2012 |
Journal: |
J Cell Biol |
Title: |
Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival. |
Volume: |
199 |
Issue: |
7 |
Pages: |
1145-58 |
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•
•
•
•
•
|
Publication |
First Author: |
Park MY |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2. |
Volume: |
7 |
Issue: |
1 |
Pages: |
15575 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim T |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation. |
Volume: |
284 |
Issue: |
22 |
Pages: |
15308-16 |
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•
•
•
•
•
|
Publication |
First Author: |
Ramaswamy G |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Gsα Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and β-Catenin Pathways. |
Volume: |
7 |
|
Pages: |
45140 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu G |
Year: |
2022 |
Journal: |
Int J Biol Sci |
Title: |
Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis. |
Volume: |
18 |
Issue: |
14 |
Pages: |
5522-5538 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyauchi Y |
Year: |
2010 |
Journal: |
J Exp Med |
Title: |
The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. |
Volume: |
207 |
Issue: |
4 |
Pages: |
751-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kanady JD |
Year: |
2015 |
Journal: |
Dev Biol |
Title: |
Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling. |
Volume: |
405 |
Issue: |
1 |
Pages: |
33-46 |
|
•
•
•
•
•
|