Sarcolemmal membrane-associated proteins (SLMAPs) are coiled-coil tail-anchored membrane proteins generated by alternative splicing mechanisms []. SLMAP isoforms are important for normal muscle development []. SLMAP possesses two alternatively spliced tail anchors (TA1 or TA2), which determine its subcellular targeting. TA1 or TA2 can direct SLMAP to the endoplasmic reticulum (ER), whilst TA2 additionally directs SLMAP to the mitochondria [].
