In humans, Rabphilin-3A (RPH3A) contains two C2 domains and one RabBD (Rab-binding) domain. RPH3A may interact with the SNARE complex and regulate synaptic vesicle exocytosis and Ca2+-triggered neurotransmitter release []. It has been linked to neurodegenerative diseases, such as Huntington's disease [], Lewy body disease []and Alzheimer's disease [].