The Olfactomedin family is a group of extracellular glycoproteins that contain an OLF domain in its C-terminal region []. Olfactomedin-like (OLFML) glycoproteins are members of Olfactomedin family. There are at least four OLFMLs: OLFML1, OLFML2A, OLFML2B and OLFML3.OLFML3 has been suggested to have a physiological role as a matrix-related component involved in placental and embryonic development []. It may be involved in eye disorders [].