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Search results 801 to 891 out of 891 for Lrp5

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Type Details Score
Interaction Experiment
Hay E (2009)
Description: N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.
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Interaction Experiment
Ellies DL (2006)
Description: Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.
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Allele
Lrp5<tm1Grw> | MGI:3612485
Name: low density lipoprotein receptor-related protein 5; targeted mutation 1, Georges Rawadi
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
15024691 | -
First Author: Toomes C
Year: 2004
Journal: Am J Hum Genet
Title: Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.
Volume: 74
Issue: 4
Pages: 721-30
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Allele
Lrp5<em1Smoc> | MGI:7290871
Name: low density lipoprotein receptor-related protein 5; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Lrp5/Lrp5
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Publication
15143163 | -
First Author: Zhang Y
Year: 2004
Journal: Mol Cell Biol
Title: The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.
Volume: 24
Issue: 11
Pages: 4677-84
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DO Term
DOID:0111411 | exudative vitreoretinopathy 4
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DO Term
DOID:0080037 | Worth syndrome
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Allele
Lrp5<tm1Kry> | MGI:2183279
Name: low density lipoprotein receptor-related protein 5; targeted mutation 1, Gerard Karsenty
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Tg(Pbsn-Lrp5/Fkbp1a,-luc*)#Dmps | MGI:5633983
Name: transgene insertion, David M Spencer
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Lrp5/Lrp5<+>
Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lrp5/Lrp5
Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0060849 | osteoporosis-pseudoglioma syndrome
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DO Term
DOID:0110937 | autosomal dominant osteopetrosis 1
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Allele
Tg(H-2K1-Lrp5/Fkbp1a,-luc*)#Dmps | MGI:5633960
Name: transgene insertion, David M Spencer
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Allele
Lrp5<tm3(Lrp5*)Kry> | MGI:3837395
Name: low density lipoprotein receptor-related protein 5; targeted mutation 3, Gerard Karsenty
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Tg(Pbsn-Lrp5/Fkbp1a,-luc*)#Dmps/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Publication
11029007 | J:166033
First Author: Tamai K
Year: 2000
Journal: Nature
Title: LDL-receptor-related proteins in Wnt signal transduction.
Volume: 407
Issue: 6803
Pages: 530-5
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HT Experiment
E-GEOD-32145 | Retinal gene expression of low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice
Series Id: GSE32145
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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GO Term
GO:1990909 | Wnt signalosome
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Strain
MGI:4453209 | 129S.129-Lrp5<tm1Grw>/J
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Lrp5<r18> | MGI:3774282
 
Name: low density lipoprotein receptor-related protein 5; r18
Allele Type: Chemically induced (ENU)
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Genotype
Genotype
Symbol: Tg(H-2K1-Lrp5/Fkbp1a,-luc*)#Dmps/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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HT Experiment
E-GEOD-56461 | The transcriptional response to Norrin/Fz4 signaling
Series Id: GSE56461
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:3806567 | C57BL/6J-Lrp5<r18>
Attribute String: coisogenic, chemically induced mutation
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Genotype
Genotype
Symbol: Lrp5/Lrp5
Background: C57BL/6J-Lrp5
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Pbsn-Fgfr1/Fkbp1a)#aDmsp/? Tg(Pbsn-Lrp5/Fkbp1a,-luc*)#Dmps/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
GSE19228 | Expression Analysis of Mammary Epithelial Cells Isolated from 12-16 Week Old Virgin C57Bl6 Lrp5+/+ and Lrp5-/- Mice
Series Id: E-GEOD-19228
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Genotype
Genotype
Symbol: Lrp5/Lrp5 Tg(Vil1-cre)20Syr/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lrp5/Lrp5 Tg(Col1a1-cre)1Kry/?
Background: involves: FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lrp5/Lrp5 Sost/Sost
Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(H-2K1-Lrp5/Fkbp1a,-luc*)#Dmps/? Tg(Pbsn-Fgfr1/Fkbp1a)#aDmsp/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
26048454 | -
First Author: Lara-Castillo N
Year: 2015
Journal: Rev Endocr Metab Disord
Title: LRP receptor family member associated bone disease.
Volume: 16
Issue: 2
Pages: 141-8
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Publication
17332414 | -
First Author: Mani A
Year: 2007
Journal: Science
Title: LRP6 mutation in a family with early coronary disease and metabolic risk factors.
Volume: 315
Issue: 5816
Pages: 1278-82
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Protein Domain
IPR017049 | LRP5/6
Type: Family
Description: LRP5/6 are transmembrane receptors that are involved in Wnt signal transduction []. Binding of the Wnts to LRP5/6 and their participating co-receptors, the frizzled (Fz) family of 7 transmembrane spanning proteins, results in a series of downstream intracelullar events, in particular the inhibition by subsequent phosphorylation of GSK-3beta []. LRP5/6 have been shown to play an role in bone homeostasis []. Mutations in the LRP5 gene cause vitreoretinopathy, exudative 4 (EVR4), a disorder of the retinal vasculature characterised by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina []. Mutations in the LRP6 gene cause coronary artery disease, autosomal dominant, 2 (ADCAD2), a common heart disease characterised by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart [].
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Publication
24305876 | J:206727
First Author: Carstens JL
Year: 2014
Journal: Cancer Res
Title: FGFR1-WNT-TGF-β signaling in prostate cancer mouse models recapitulates human reactive stroma.
Volume: 74
Issue: 2
Pages: 609-20
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Publication
19524639 | J:155062
First Author: Milat F
Year: 2009
Journal: Mol Cell Endocrinol
Title: Is Wnt signalling the final common pathway leading to bone formation?
Volume: 310
Issue: 1-2
Pages: 52-62
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Publication
22357953 | J:197712
First Author: Bikkavilli RK
Year: 2012
Journal: J Cell Sci
Title: Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.
Volume: 125
Issue: Pt 10
Pages: 2446-56
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Publication
9704021 | J:49065
First Author: Brown SD
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.
Volume: 248
Issue: 3
Pages: 879-88
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Publication
15908424 | J:164786
First Author: Semënov M
Year: 2005
Journal: J Biol Chem
Title: SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.
Volume: 280
Issue: 29
Pages: 26770-5
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Publication
23334081 | J:199556
First Author: Wan Y
Year: 2013
Journal: Bone
Title: Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of bone marrow mesenchymal stem cells.
Volume: 55
Issue: 1
Pages: 258-67
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Publication
15802266 | J:99904
First Author: Holmen SL
Year: 2005
Journal: J Biol Chem
Title: Essential role of beta-catenin in postnatal bone acquisition.
Volume: 280
Issue: 22
Pages: 21162-8
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Publication
24670389 | J:210471
 
First Author: Okamoto M
Year: 2014
Journal: Sci Rep
Title: Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteoblastogenesis.
Volume: 4
Pages: 4493
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Publication
31585407 | J:305286
 
First Author: Bullock WA
Year: 2019
Journal: iScience
Title: Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo.
Volume: 20
Pages: 205-215
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Publication
23623748 | J:203493
First Author: Esen E
Year: 2013
Journal: Cell Metab
Title: WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.
Volume: 17
Issue: 5
Pages: 745-55
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Publication
24851717 | J:217133
First Author: Ozeki N
Year: 2014
Journal: Exp Cell Res
Title: IL-1β-induced, matrix metalloproteinase-3-regulated proliferation of embryonic stem cell-derived odontoblastic cells is mediated by the Wnt5 signaling pathway.
Volume: 328
Issue: 1
Pages: 69-86
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Publication
29584620 | J:263612
First Author: Zhang Y
Year: 2018
Journal: J Clin Invest
Title: JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.
Volume: 128
Issue: 5
Pages: 1737-1751
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Publication
31584963 | J:280039
First Author: Nordberg RC
Year: 2019
Journal: PLoS One
Title: LRP receptors in chondrocytes are modulated by simulated microgravity and cyclic hydrostatic pressure.
Volume: 14
Issue: 10
Pages: e0223245
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Publication
30842262 | J:278215
First Author: Kim SP
Year: 2019
Journal: J Biol Chem
Title: Lrp4 expression by adipocytes and osteoblasts differentially impacts sclerostin's endocrine effects on body composition and glucose metabolism.
Volume: 294
Issue: 17
Pages: 6899-6911
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Publication
27143110 | J:235518
 
First Author: Kang KS
Year: 2016
Journal: Bone
Title: Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation.
Volume: 88
Pages: 138-145
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Publication
18487199 | J:138745
First Author: Cheng SL
Year: 2008
Journal: J Biol Chem
Title: Msx2 exerts bone anabolism via canonical Wnt signaling.
Volume: 283
Issue: 29
Pages: 20505-22
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Publication
20439124 | J:174163
First Author: Phillips MD
Year: 2011
Journal: Int J Cardiol
Title: Dkk1 and Dkk2 regulate epicardial specification during mouse heart development.
Volume: 150
Issue: 2
Pages: 186-92
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Publication
22865881 | J:191590
First Author: Tran TH
Year: 2012
Journal: J Biol Chem
Title: Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration.
Volume: 287
Issue: 39
Pages: 32651-64
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Publication
22394677 | J:184472
First Author: Zuercher J
Year: 2012
Journal: Hum Mol Genet
Title: Norrin stimulates cell proliferation in the superficial retinal vascular plexus and is pivotal for the recruitment of mural cells.
Volume: 21
Issue: 12
Pages: 2619-30
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Publication
18547247 | J:137141
First Author: Luhmann UF
Year: 2008
Journal: Eur J Neurosci
Title: Vascular changes in the cerebellum of Norrin /Ndph knockout mice correlate with high expression of Norrin and Frizzled-4.
Volume: 27
Issue: 10
Pages: 2619-28
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Publication
15115753 | J:91047
First Author: MacDonald BT
Year: 2004
Journal: Development
Title: Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6.
Volume: 131
Issue: 11
Pages: 2543-52
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Publication
28694256 | J:243416
First Author: Ahn Y
Year: 2017
Journal: Development
Title: Multiple modes of Lrp4 function in modulation of Wnt/β-catenin signaling during tooth development.
Volume: 144
Issue: 15
Pages: 2824-2836
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Publication
19498022 | J:150055
First Author: Zhang C
Year: 2009
Journal: J Nutr
Title: The bone morphogenetic protein signaling pathway is upregulated in a mouse model of total parenteral nutrition.
Volume: 139
Issue: 7
Pages: 1315-21
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Publication
16805831 | J:239208
First Author: Caruso A
Year: 2006
Journal: J Neurochem
Title: Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells.
Volume: 98
Issue: 2
Pages: 364-71
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Publication
12931195 | J:248454
First Author: Takagi J
Year: 2003
Journal: Nature
Title: Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface.
Volume: 424
Issue: 6951
Pages: 969-74
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Publication
16263759 | J:103781
First Author: Li Y
Year: 2005
Journal: J Cell Sci
Title: Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.
Volume: 118
Issue: Pt 22
Pages: 5305-14
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Publication
12121999 | J:172892
First Author: Holmen SL
Year: 2002
Journal: J Biol Chem
Title: A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.
Volume: 277
Issue: 38
Pages: 34727-35
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Publication
16730481 | J:114081
First Author: Li J
Year: 2006
Journal: Bone
Title: Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia.
Volume: 39
Issue: 4
Pages: 754-66
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Publication
16908522 | J:117189
First Author: Robinson JA
Year: 2006
Journal: J Biol Chem
Title: Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone.
Volume: 281
Issue: 42
Pages: 31720-8
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Publication
29777010 | J:264117
 
First Author: Nayak G
Year: 2018
Journal: Development
Title: Developmental vascular regression is regulated by a Wnt/β-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death.
Volume: 145
Issue: 12
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Protein Coding Gene
MGI:1855698 | Reck
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31564437 | J:287028
First Author: Moosa S
Year: 2019
Journal: Am J Hum Genet
Title: Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta.
Volume: 105
Issue: 4
Pages: 836-843
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Publication
28467820 | J:252529
First Author: Yan KS
Year: 2017
Journal: Nature
Title: Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.
Volume: 545
Issue: 7653
Pages: 238-242
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Publication
21541292 | J:172378
First Author: Kim S
Year: 2011
Journal: PLoS One
Title: Differentiation generates paracrine cell pairs that maintain basaloid mouse mammary tumors: proof of concept.
Volume: 6
Issue: 4
Pages: e19310
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Publication
30354230 | J:279603
First Author: Zhang C
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial Cell-Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature.
Volume: 38
Issue: 11
Pages: 2691-2705
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Publication
12812787 | J:84052
First Author: Stump RJ
Year: 2003
Journal: Dev Biol
Title: A role for Wnt/beta-catenin signaling in lens epithelial differentiation.
Volume: 259
Issue: 1
Pages: 48-61
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Publication
17613296 | J:142933
First Author: MacDonald BT
Year: 2007
Journal: Bone
Title: Bone mass is inversely proportional to Dkk1 levels in mice.
Volume: 41
Issue: 3
Pages: 331-9
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Publication
19936252 | J:155399
First Author: Choi HY
Year: 2009
Journal: PLoS One
Title: Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.
Volume: 4
Issue: 11
Pages: e7930
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Publication
16753024 | J:128096
First Author: Morvan F
Year: 2006
Journal: J Bone Miner Res
Title: Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.
Volume: 21
Issue: 6
Pages: 934-45
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Publication
28143772 | J:316018
First Author: Lai KKY
Year: 2017
Journal: Gastroenterology
Title: Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.
Volume: 152
Issue: 6
Pages: 1477-1491
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Protein Coding Gene
MGI:108100 | Dvl3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1925810 | Adgra2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q91VN0
Organism: Mus musculus/domesticus
Length: 1614  
Fragment?: false
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Protein
O88572
Organism: Mus musculus/domesticus
Length: 1613  
Fragment?: false
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Protein
Q3UI55
Organism: Mus musculus/domesticus
Length: 1614  
Fragment?: false
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Protein
Q571K3
Organism: Mus musculus/domesticus
Length: 1639  
Fragment?: true
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Protein
A0A0R4J0A9
Organism: Mus musculus/domesticus
Length: 1613  
Fragment?: false
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Protein Coding Gene
MGI:98953 | Wnt1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1096327 | Axin1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:94941 | Dvl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98956 | Wnt3a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1298218 | Lrp6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913975 | Lrrk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1861437 | Gsk3b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88276 | Ctnnb1
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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