Type |
Details |
Score |
Publication |
First Author: |
Naigamwalla D |
Year: |
2000 |
Journal: |
Cancer Res |
Title: |
Polyethylene glycol 8000 and colon carcinogenesis: inhibition in the F344 rat, promotion in the Min mouse. |
Volume: |
60 |
Issue: |
24 |
Pages: |
6856-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng Y |
Year: |
2021 |
Journal: |
Nature |
Title: |
FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. |
Volume: |
600 |
Issue: |
7888 |
Pages: |
324-328 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oda S |
Year: |
2005 |
Journal: |
Nucleic Acids Res |
Title: |
Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability. |
Volume: |
33 |
Issue: |
5 |
Pages: |
1628-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Will B |
Year: |
2015 |
Journal: |
Nat Med |
Title: |
Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia. |
Volume: |
21 |
Issue: |
10 |
Pages: |
1172-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cranston A |
Year: |
1999 |
Journal: |
Mamm Genome |
Title: |
Female embryonic lethality in Msh2-Trp53 nullizygous mice is strain dependent. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1020-2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Enoiu M |
Year: |
2012 |
Journal: |
Nucleic Acids Res |
Title: |
Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis. |
Volume: |
40 |
Issue: |
18 |
Pages: |
8953-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Oers JM |
Year: |
2014 |
Journal: |
Oncogene |
Title: |
The MutSĪ² complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair. |
Volume: |
33 |
Issue: |
30 |
Pages: |
3939-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martinez-Usatorre A |
Year: |
2021 |
Journal: |
Sci Transl Med |
Title: |
Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models. |
Volume: |
13 |
Issue: |
606 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Boulianne B |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
AID and caspase 8 shape the germinal center response through apoptosis. |
Volume: |
191 |
Issue: |
12 |
Pages: |
5840-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Campbell MR |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
A lack of DNA mismatch repair on an athymic murine background predisposes to hematologic malignancy. |
Volume: |
65 |
Issue: |
7 |
Pages: |
2626-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schrader CE |
Year: |
1999 |
Journal: |
J Exp Med |
Title: |
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. |
Volume: |
190 |
Issue: |
3 |
Pages: |
323-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Owens JA |
Year: |
2021 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
Lactobacillus rhamnosus GG Orchestrates an Antitumor Immune Response. |
Volume: |
12 |
Issue: |
4 |
Pages: |
1311-1327 |
|
•
•
•
•
•
|
Publication |
First Author: |
Albertson TM |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice. |
Volume: |
106 |
Issue: |
40 |
Pages: |
17101-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Belcheva A |
Year: |
2014 |
Journal: |
Cell |
Title: |
Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells. |
Volume: |
158 |
Issue: |
2 |
Pages: |
288-299 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sansom OJ |
Year: |
2001 |
Journal: |
Cancer Res |
Title: |
Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice. |
Volume: |
61 |
Issue: |
19 |
Pages: |
7060-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Belcheva A |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Elevated incidence of polyp formation in APC(Min/āŗ)Msh2ā»/ā» mice is independent of nitric oxide-induced DNA mutations. |
Volume: |
8 |
Issue: |
5 |
Pages: |
e65204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kucherlapati MH |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon. |
Volume: |
105 |
Issue: |
40 |
Pages: |
15493-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bacher JW |
Year: |
2005 |
Journal: |
Mol Carcinog |
Title: |
Use of mononucleotide repeat markers for detection of microsatellite instability in mouse tumors. |
Volume: |
44 |
Issue: |
4 |
Pages: |
285-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shenkar R |
Year: |
2015 |
Journal: |
Genet Med |
Title: |
Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. |
Volume: |
17 |
Issue: |
3 |
Pages: |
188-196 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jinnah HA |
Year: |
1993 |
Journal: |
J Neurochem |
Title: |
Brain purines in a genetic mouse model of Lesch-Nyhan disease. |
Volume: |
60 |
Issue: |
6 |
Pages: |
2036-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao XN |
Year: |
2015 |
Journal: |
Hum Mutat |
Title: |
The transcription-coupled repair protein ERCC6/CSB also protects against repeat expansion in a mouse model of the fragile X premutation. |
Volume: |
36 |
Issue: |
4 |
Pages: |
482-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hance KW |
Year: |
2005 |
Journal: |
Mutat Res |
Title: |
Mouse models expressing human carcinoembryonic antigen (CEA) as a transgene: evaluation of CEA-based cancer vaccines. |
Volume: |
576 |
Issue: |
1-2 |
Pages: |
132-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boivin GP |
Year: |
2003 |
Journal: |
Gastroenterology |
Title: |
Pathology of mouse models of intestinal cancer: consensus report and recommendations. |
Volume: |
124 |
Issue: |
3 |
Pages: |
762-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vuong BQ |
Year: |
2013 |
Journal: |
Nat Immunol |
Title: |
A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. |
Volume: |
14 |
Issue: |
11 |
Pages: |
1183-1189 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schrader CE |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair. |
Volume: |
179 |
Issue: |
9 |
Pages: |
6064-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pastille E |
Year: |
2019 |
Journal: |
Mucosal Immunol |
Title: |
The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer. |
Volume: |
12 |
Issue: |
4 |
Pages: |
990-1003 |
|
•
•
•
•
•
|
Publication |
First Author: |
Irrazabal T |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer. |
Volume: |
11 |
Issue: |
1 |
Pages: |
1802 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshioka K |
Year: |
2006 |
Journal: |
Mol Cell |
Title: |
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. |
Volume: |
22 |
Issue: |
4 |
Pages: |
501-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ghodgaonkar MM |
Year: |
2013 |
Journal: |
Mol Cell |
Title: |
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. |
Volume: |
50 |
Issue: |
3 |
Pages: |
323-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
PeltomƤki P |
Year: |
2001 |
Journal: |
Mutat Res |
Title: |
DNA mismatch repair and cancer. |
Volume: |
488 |
Issue: |
1 |
Pages: |
77-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmutte C |
Year: |
1998 |
Journal: |
Cancer Res |
Title: |
Refined chromosomal localization of the mismatch repair and hereditary nonpolyposis colorectal cancer genes hMSH2 and hMSH6. |
Volume: |
58 |
Issue: |
22 |
Pages: |
5023-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oliver G |
Year: |
1995 |
Journal: |
Development |
Title: |
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. |
Volume: |
121 |
Issue: |
12 |
Pages: |
4045-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spehlmann ME |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Trp53 deficiency protects against acute intestinal inflammation. |
Volume: |
191 |
Issue: |
2 |
Pages: |
837-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kolas NK |
Year: |
2005 |
Journal: |
J Cell Biol |
Title: |
Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. |
Volume: |
171 |
Issue: |
3 |
Pages: |
447-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kneitz B |
Year: |
2000 |
Journal: |
Genes Dev |
Title: |
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. |
Volume: |
14 |
Issue: |
9 |
Pages: |
1085-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jacobs H |
Year: |
1998 |
Journal: |
J Exp Med |
Title: |
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice. |
Volume: |
187 |
Issue: |
11 |
Pages: |
1735-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keil KP |
Year: |
2013 |
Journal: |
Gene Expr Patterns |
Title: |
Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract. |
Volume: |
13 |
Issue: |
8 |
Pages: |
413-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Koss M |
Year: |
2012 |
Journal: |
Dev Cell |
Title: |
Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. |
Volume: |
22 |
Issue: |
5 |
Pages: |
913-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
|
Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gaudet P |
Year: |
2011 |
Journal: |
Brief Bioinform |
Title: |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Volume: |
12 |
Issue: |
5 |
Pages: |
449-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
2 |
Description: |
DNA mismatch repair protein Msh2 |
Type: |
chain |
End: |
935 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
68
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Houlleberghs H |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants. |
Volume: |
113 |
Issue: |
15 |
Pages: |
4128-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vani RG |
Year: |
1997 |
Journal: |
Gene |
Title: |
Cloning of the cDNA encoding rat homologue of the mismatch repair gene MSH2 and its expression during spermatogenesis. |
Volume: |
185 |
Issue: |
1 |
Pages: |
19-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirayama Y |
Year: |
1999 |
Journal: |
Exp Anim |
Title: |
Linkage mapping of the rat Msh2 DNA mismatch repair gene on chromosome 6. |
Volume: |
48 |
Issue: |
1 |
Pages: |
63-4 |
|
•
•
•
•
•
|
Allele |
Name: |
mutS homolog 2; targeted mutation 2, Hein Te Riele |
Allele Type: |
Targeted |
Attribute String: |
Not Specified |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Bhandari A |
Year: |
2013 |
Journal: |
Oncogene |
Title: |
The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21 expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by RNA-binding protein DND1. |
Volume: |
32 |
Issue: |
12 |
Pages: |
1497-507 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Allele |
Name: |
mutS homolog 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Mismatch repair (MMR) is one of five major DNA repair pathways, the others being homologous recombination repair, non-homologous end joining, nucleotide excision repair, and base excision repair. The mismatch repair system recognises and repairs mispaired or unpaired nucleotides that result from errors in DNA replication. The most extensively studied general MMR system is the MutHLS pathway of the bacterium Escherichia coli. In the first step of the MutHLS pathway, the MutS protein (in the form of a dimer) binds to the site of a mismatch in double-stranded DNA. Through a complex interaction between MutS, MutL and MutH, a section of the newly replicated DNA strand (and thus the strand with the replication error) at the location of the mismatch bound by MutS is targeted for removal []. Homologues of MutS have been found in many species including eukaryotes, Archaea and other bacteria, and together these proteins have been grouped into the MutS family.This entry represents a subset of the MutS family members, including Msh2. Msh2 (MutS homologue 2) has a dual role in DNA repair and apoptosis. Msh2 acts as a heterodimer with Msh6, which together function to recruit the Mlh (MutL homologue) - Pms (post-meiotic segregation) heterodimer, and to replace the mispaired base []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Baker SM |
Year: |
1996 |
Journal: |
Nat Genet |
Title: |
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. |
Volume: |
13 |
Issue: |
3 |
Pages: |
336-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Drotschmann K |
Year: |
2002 |
Journal: |
Biol Chem |
Title: |
DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers. |
Volume: |
383 |
Issue: |
6 |
Pages: |
969-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Edelmann W |
Year: |
1996 |
Journal: |
Cell |
Title: |
Meiotic pachytene arrest in MLH1-deficient mice. |
Volume: |
85 |
Issue: |
7 |
Pages: |
1125-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Delbos F |
Year: |
2005 |
Journal: |
J Exp Med |
Title: |
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse. |
Volume: |
201 |
Issue: |
8 |
Pages: |
1191-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ehrenstein MR |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination. |
Volume: |
98 |
Issue: |
25 |
Pages: |
14553-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krijger PH |
Year: |
2013 |
Journal: |
Eur J Immunol |
Title: |
Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway. |
Volume: |
43 |
Issue: |
10 |
Pages: |
2765-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu S |
Year: |
2015 |
Journal: |
EMBO J |
Title: |
Okazaki fragment maturation involves Ī±-segment error editing by the mammalian FEN1/MutSĪ± functional complex. |
Volume: |
34 |
Issue: |
13 |
Pages: |
1829-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Phung QH |
Year: |
1999 |
Journal: |
J Immunol |
Title: |
Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein. |
Volume: |
162 |
Issue: |
6 |
Pages: |
3121-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horii A |
Year: |
1994 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes. |
Volume: |
204 |
Issue: |
3 |
Pages: |
1257-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Prolla TA |
Year: |
1996 |
Journal: |
Semin Cancer Biol |
Title: |
DNA mismatch repair deficient mice in cancer research. |
Volume: |
7 |
Issue: |
5 |
Pages: |
241-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sansom OJ |
Year: |
2004 |
Journal: |
Oncogene |
Title: |
MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR. |
Volume: |
23 |
Issue: |
33 |
Pages: |
5693-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
MartĆn-LĆ³pez J |
Year: |
2018 |
Journal: |
Oncotarget |
Title: |
Mutation of TGFĪ²-RII eliminates NSAID cancer chemoprevention. |
Volume: |
9 |
Issue: |
16 |
Pages: |
12554-12561 |
|
•
•
•
•
•
|
Publication |
First Author: |
van den Broek WJ |
Year: |
2002 |
Journal: |
Hum Mol Genet |
Title: |
Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins. |
Volume: |
11 |
Issue: |
2 |
Pages: |
191-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Foiry L |
Year: |
2006 |
Journal: |
Hum Genet |
Title: |
Msh3 is a limiting factor in the formation of intergenerational CTG expansions in DM1 transgenic mice. |
Volume: |
119 |
Issue: |
5 |
Pages: |
520-6 |
|
•
•
•
•
•
|