Caspase recruiment domain-containing proteins (CARDs) are death domains (DDs) found associated with caspases []. They are known to be important in the signalling pathways for apoptosis, inflammation, and host-defense mechanisms [].This entry includes the Caspase-recruitment domain-containing protein 19 (CARD19), also known as Bcl10-interacting protein with CARD (BinCARD) which interacts with apoptosis inducer CARD protein Bcl10 through CARD. It inhibits Bcl10-mediated activation of NF-kappa B and to suppress Bcl10 phosphorylation [].
