Protein Shroom3 (Shrm3) belongs to the Shroom family, whose members are linked to the actin cytoskeleton []. Shrm3 is an actin binding protein that directs Rho kinase- and RhoA-dependent apical constriction in the lens placode and partially facilitates invagination [, , , ]. It is recruited to adherens junctions by cadherin-binding ZA (zonula adherens) protein p120-catenin during lens pit morphogenesis []. It is necessary for neural tube closure in vertebrate development [, ].
