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Search results 201 to 212 out of 212 for Fermt3

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Type Details Score
Protein Domain
IPR037837 | PH_Kindlin/fermitin
Type: Domain
Description: Fermitin, also known as Unc-112-related protein [], functions as a mediator of integrin inside-out signalling. The recruitment of Fermitin proteins and Talin to the membrane mediates the terminal event of integrin signalling, via interaction with integrin beta subunits []. Fermatin has a FERM domain interrupted with a pleckstrin homology (PH) domain []. Fermitin family homologues (Fermt1, 2, and 3, also known as Kindlins) are each encoded by a different gene. In mammalian studies, Fermt1 is generally expressed in epithelial cells, Fermt2 is expressed in muscle tissues, and Fermt3 is expressed in hematopoietic lineages. Specifically Fermt2 is expressed in smooth and striated muscle tissues in mice and in the somites (a trunk muscle precursor) and neural crest in Xenopus embryos. As such it has been proposed that Fermt2 plays a role in cardiomyocyte and neural crest differentiation. Expression of mammalian Fermt3 is associated with hematopoietic lineages: the anterior ventral blood islands, vitelline veins, and early myeloid cells. In Xenopus embryos this expression, also include the notochord and cement gland [, ].This entry represents the PH domain of fermitins.
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Protein Domain
IPR037843 | Kindlin/fermitin
Type: Family
Description: Fermitin, also known as Unc-112-related protein [], functions as a mediator of integrin inside-out signalling. The recruitment of Fermitin proteins and Talin to the membrane mediates the terminal event of integrin signalling, via interaction with integrin beta subunits []. Fermatin has a FERM domain interrupted with a pleckstrin homology (PH) domain []. Fermitin family homologues (Fermt1, 2, and 3, also known as Kindlins) are each encoded by a different gene. In mammalian studies, Fermt1 is generally expressed in epithelial cells, Fermt2 is expressed in muscle tissues, and Fermt3 is expressed in hematopoietic lineages. Specifically Fermt2 is expressed in smooth and striated muscle tissues in mice and in the somites (a trunk muscle precursor) and neural crest in Xenopus embryos. As such it has been proposed that Fermt2 plays a role in cardiomyocyte and neural crest differentiation. Expression of mammalian Fermt3 is associated with hematopoietic lineages: the anterior ventral blood islands, vitelline veins, and early myeloid cells. In Xenopus embryos this expression, also include the notochord and cement gland [, ].
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Protein
Q8K1B8
Organism: Mus musculus/domesticus
Length: 665  
Fragment?: false
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Protein
Q8CIB5
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
P59113
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
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Protein
Q3TLE2
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
Q3TEE6
Organism: Mus musculus/domesticus
Length: 665  
Fragment?: false
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Protein
Q4W4Z0
Organism: Mus musculus/domesticus
Length: 491  
Fragment?: false
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Protein
A6X941
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
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Protein
Q3UMA4
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
A0A494B9W3
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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