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Search results 1201 to 1300 out of 1601 for Smad2

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Type Details Score
Publication
24449835 | J:208341
First Author: Seth A
Year: 2014
Journal: Development
Title: Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.
Volume: 141
Issue: 3
Pages: 538-47
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Publication
27224923 | J:302089
First Author: Vezzali R
Year: 2016
Journal: Oncotarget
Title: The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons.
Volume: 7
Issue: 25
Pages: 37436-37455
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Publication
35247391 | J:323229
First Author: Rosendahl AH
Year: 2022
Journal: J Biol Chem
Title: Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.
Volume: 298
Issue: 4
Pages: 101787
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Publication
23592779 | J:199615
First Author: Cases O
Year: 2013
Journal: J Biol Chem
Title: Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.
Volume: 288
Issue: 23
Pages: 16655-70
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Publication
37973188 | J:342617
 
First Author: Dali O
Year: 2024
Journal: Life Sci Alliance
Title: Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure.
Volume: 7
Issue: 2
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Publication
15342483 | J:108109
First Author: Oxburgh L
Year: 2004
Journal: Development
Title: TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.
Volume: 131
Issue: 18
Pages: 4593-605
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Publication
30718289 | J:272613
 
First Author: Koutelou E
Year: 2019
Journal: Development
Title: USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta.
Volume: 146
Issue: 4
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
27480124 | J:237787
First Author: Liu X
Year: 2016
Journal: BMC Immunol
Title: Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Volume: 17
Issue: 1
Pages: 25
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Publication
22560297 | J:184521
First Author: Koss M
Year: 2012
Journal: Dev Cell
Title: Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.
Volume: 22
Issue: 5
Pages: 913-26
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Publication
20412781 | J:140465
First Author: Guo G
Year: 2010
Journal: Dev Cell
Title: Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Volume: 18
Issue: 4
Pages: 675-85
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Strain
MGI:5495035 | STOCK Smad2<tm4(SMADH3)Rob>/H
Attribute String: mutant stock, targeted mutation
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Publication
28334068 | J:242251
First Author: Franquinho F
Year: 2017
Journal: Cereb Cortex
Title: The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling.
Volume: 27
Issue: 3
Pages: 1732-1747
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Publication
31399586 | J:279317
First Author: Chen H
Year: 2019
Journal: Nat Commun
Title: WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling.
Volume: 10
Issue: 1
Pages: 3616
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Publication
26354229 | J:227015
 
First Author: Tang YN
Year: 2015
Journal: Nat Commun
Title: Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis.
Volume: 6
Pages: 8230
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Strain
MGI:5490232 | STOCK Smad2<tm3Rob>/H
Attribute String: targeted mutation, mutant strain, Not Applicable
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Publication
18773928 | J:142429
First Author: Hoover LL
Year: 2008
Journal: Biochim Biophys Acta
Title: Retinoids regulate TGFbeta signaling at the level of Smad2 phosphorylation and nuclear accumulation.
Volume: 1783
Issue: 12
Pages: 2279-86
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Publication
32374679 | J:302107
     
First Author: Dai J
Year: 2020
Journal: Am J Physiol Cell Physiol
Title: Osteoclast-derived exosomal let-7a-5p targets Smad2 to promote the hypertrophic differentiation of chondrocytes.
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Publication
16354202 | J:128974
First Author: Hosokawa R
Year: 2005
Journal: J Invest Dermatol
Title: Functional significance of Smad2 in regulating basal keratinocyte migration during wound healing.
Volume: 125
Issue: 6
Pages: 1302-9
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Publication
9501027 | J:46375
First Author: Zhao J
Year: 1998
Journal: Dev Biol
Title: Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture.
Volume: 194
Issue: 2
Pages: 182-95
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Interaction Experiment
Bai Y (2004)
Description: Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation.
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Interaction Experiment
Labbe E (1998)
Description: Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2.
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GO Term
GO:0071142 | homomeric SMAD protein complex
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Publication
9865696 | -
First Author: Tsukazaki T
Year: 1998
Journal: Cell
Title: SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.
Volume: 95
Issue: 6
Pages: 779-91
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Publication
10615055 | -
First Author: Wu G
Year: 2000
Journal: Science
Title: Structural basis of Smad2 recognition by the Smad anchor for receptor activation.
Volume: 287
Issue: 5450
Pages: 92-7
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Publication
26039994 | -
First Author: Shathasivam P
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling.
Volume: 112
Issue: 23
Pages: E3000-9
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Protein
Q62432
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Allele
Smad2<tm1Smoc> | MGI:7292465
Name: SMAD family member 2; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Protein
Q62432-2
Organism: Mus musculus/domesticus
Length: 437  
Fragment?: false
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GO Term
GO:0032444 | activin responsive factor complex
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Publication
14701940 | -
First Author: Bernard DJ
Year: 2004
Journal: Mol Endocrinol
Title: Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells.
Volume: 18
Issue: 3
Pages: 606-23
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Publication
15601644 | -
First Author: Lin F
Year: 2005
Journal: Hum Mol Genet
Title: MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling.
Volume: 14
Issue: 3
Pages: 437-45
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Publication
15496141 | -
First Author: Kuratomi G
Year: 2005
Journal: Biochem J
Title: NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.
Volume: 386
Issue: Pt 3
Pages: 461-70
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Allele
Tg(Amh-SMAD2*)#Jebu | MGI:5543909
Name: transgene insertion, Joanna E Burdette
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
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Allele
Rr54<em1Axvi> | MGI:7489588
Name: Regulatory region 54; endonuclease-mediated mutation 1, Axel Visel
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Strain
MGI:6476337 | C57BL/6J-Smad2<tm1Smoc>/Smoc
Attribute String: coisogenic, targeted mutation, mutant strain
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Allele
Smad2<tm6(SMAD2)Rob> | MGI:5775212
Name: SMAD family member 2; targeted mutation 6, Elizabeth Robertson
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Smad2/Smad2
Background: involves: 129S/SvEv
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR024608 | SARA_Smad-bd
Type: Domain
Description: Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus. SARA (Smad anchor for receptor activation) recruits Smad2 to the TGF-beta receptors for phosphorylation [].This entry represents the Smad-binding domain (SBD) of SARA. This domain consists of a rigid coil, an alpha helix, and a beta strand, and interacts with Smad2 [].
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Protein Domain
IPR037145 | SARA_Smad-bd_sf
Type: Homologous_superfamily
Description: Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus. SARA (Smad anchor for receptor activation) recruits Smad2 to the TGF-beta receptors for phosphorylation [].This entry represents the Smad-binding domain (SBD) superfamily of SARA. This domain consists of a rigid coil, an alpha helix, and a beta strand, and interacts with Smad2 [].
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Protein
Q3UXU9
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
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Strain
MGI:5543943 | FVB/N-Tg(Amh-SMAD2*)#Jebu
Attribute String: transgenic, mutant strain, coisogenic
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Strain
MGI:7489910 | FVB-Rr54<em1Axvi>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6348309 | FVB/NCrl-Rr54<em1Axvi>/Mmucd
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
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Allele
Tgfbr1<tm1Mulm> | MGI:3767608
 
Name: transforming growth factor, beta receptor I; targeted mutation 1, Christine L Mummery
Allele Type: Targeted
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Allele
Tg(Amh-SMAD2*)2Tkw | MGI:5528705
Name: transgene insertion 2, Teresa K Woodruff
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tgfbr1/Tgfbr1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Amh-SMAD2*)#Jebu/?
Background: FVB/N-Tg(Amh-SMAD2*)#Jebu
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr54/Rr54
Background: FVB-Rr54
Zygosity: hm
Has Mutant Allele: true
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Publication
17292623 | J:123207
First Author: Arndt S
Year: 2007
Journal: Mol Cell Neurosci
Title: Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.
Volume: 34
Issue: 4
Pages: 603-11
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Publication
16141389 | J:129226
First Author: Bristol-Gould SK
Year: 2005
Journal: Endocrinology
Title: The development of a mouse model of ovarian endosalpingiosis.
Volume: 146
Issue: 12
Pages: 5228-36
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Genotype
Genotype
Symbol: Tg(Amh-SMAD2*)2Tkw/?
Background: involves: CD-1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Amh-SMAD2*)#Jebu/? Trp53/Trp53
Background: involves: 129P2/OlaHsd * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
17272273 | -
First Author: Chen YG
Year: 2007
Journal: J Biol Chem
Title: Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling.
Volume: 282
Issue: 13
Pages: 9688-95
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Publication
12432064 | -
First Author: Hu Y
Year: 2002
Journal: J Cell Sci
Title: SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.
Volume: 115
Issue: Pt 24
Pages: 4755-63
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Protein Domain
IPR035438 | SARA/endofin
Type: Family
Description: This group represents zinc finger FYVE domain-containing proteins SARA and endofin.SARA (also known as zinc finger FYVE domain-containing protein 9) is a component of the TGFbeta pathway that functions to recruit Smad2 to the TGFbeta receptor []. Endofin (zinc finger FYVE domain-containing protein 16) facilitates TGF-beta signaling by bringing Smad4 to the proximity of the receptor complex []. Both are involved in regulating membrane trafficking in the endosomal pathway [, ].
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Publication
15388229 | J:94922
First Author: Muto E
Year: 2004
Journal: Biochimie
Title: Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates.
Volume: 86
Issue: 8
Pages: 523-31
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Publication
16054033 | -
First Author: Teleman AA
Year: 2005
Journal: Dev Cell
Title: Drosophila Melted modulates FOXO and TOR activity.
Volume: 9
Issue: 2
Pages: 271-81
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Protein Domain
IPR028762 | SKOR1
Type: Family
Description: Ski family transcriptional corepressor 1 (SKOR1), also known as ladybird homeobox corepressor 1 or fussel-15 homologue, belongs to Ski family. Like the other members, it is characterised by a Ski homologue domain and a SAND domain - a domain found in some nuclear proteins involved in chromatin-dependent transcriptional regulation. Fussel-15 is mainly expressed in the central nervous system (CNS). The Ski family of nuclear oncoproteins is known to repress transforming growth factor-beta (TGF-beta) signalling through inhibition of transcriptional activity of Smad proteins. Fussel-15 interacts with Smad1, Smad2 and Smad3 molecules and suppresses mainly BMP signalling pathway, but it has only minor effects on TGF-beta signalling [].
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Protein Domain
IPR039888 | Melted-like
Type: Family
Description: This entry includes protein melted from fruit flies and its homologues. They contain a single C-terminal PH domain that is required for membrane targeting. Melted interacts with both Tsc1 and FOXO and can recruit them to the cell membrane []. In vertebrates the melted protein homologue, veph, is expressed in the developing central nervous system []. The human homologue VEPH1 (ventricular zone-expressed PH domain-containing protein homologue 1) has been shown to inhibit TGF-beta signaling by impeding the release of activated SMAD2 from TbetaRI [].
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Publication
19398960 | J:149886
First Author: Itoh F
Year: 2009
Journal: Lab Invest
Title: Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation.
Volume: 89
Issue: 7
Pages: 800-10
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