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Search results 101 to 146 out of 146 for Vps8

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Type Details Score
Allele
Vps8<Gt(E159A10)Wrst> | MGI:3916431
 
Name: VPS8 CORVET complex subunit; gene trap E159A10, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Vps8<Gt(IST14210C8)Tigm> | MGI:5214801
 
Name: VPS8 CORVET complex subunit; gene trap IST14210C8, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Vps8<Gt(XT0406)Wtsi> | MGI:4338357
 
Name: VPS8 CORVET complex subunit; gene trap XT0406, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Protein Domain
IPR025941 | Vps8_central_dom
Type: Domain
Description: Vps8 is one of the Golgi complex components necessary for vacuolar sorting []. Eukaryotic cells contain a highly dynamic endo-membrane system, in which individual organelles keep their identity despite continuous vesicle generation and fusion. Vesicles that bud from a donor membrane are targeted and delivered to each individual organelle, where they release their cargo after fusion with the acceptor membrane. Vps8 is the core component of the endosomal tethering complex CORVET (class C core vacuole/endosome tethering). Vps8 co-operates with Vps21-GTP to mediate endosomal clustering in a reaction that is dependent on Vps3. Vps8 is the only CORVET subunit that is enriched on late endosomes, suggesting that it is a marker for the maturation of late endosomes. Late endosomes form intralumenal vesicles, and the resulting multivesicular bodies fuse with the vacuole to release their cargoes [].This entry represents the central domain of Vps8.
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Publication
28079294 | J:303150
First Author: Suto JI
Year: 2017
Journal: Congenit Anom (Kyoto)
Title: Locus on chromosome 16 is significantly associated with increased tendency to lose pups in females of the RR/Sgn inbred mouse strain.
Volume: 57
Issue: 2
Pages: 57-60
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Protein Domain
IPR045111 | Vps41/Vps8
Type: Family
Description: This entry includes Vps41 and Vps8.Vps41 is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport [, , ].Vps8 is one of the Golgi complex components necessary for vacuolar sorting []. Eukaryotic cells contain a highly dynamic endomembrane system, in which individual organelles keep their identity despite continuous vesicle generation and fusion. Vesicles that bud from a donor membrane are targeted and delivered to each individual organelle, where they release their cargo after fusion with the acceptor membrane. Vps8 is the core component of the endosomal tethering complex CORVET (class C core vacuole/endosome tethering). Vps8 co-operates with Vps21-GTP to mediate endosomal clustering in a reaction that is dependent on Vps3. Vps8 is the only CORVET subunit that is enriched on late endosomes, suggesting that it is a marker for the maturation of late endosomes. Late endosomes form intraluminal vesicles, and the resulting multivesicular bodies fuse with the vacuole to release their cargoes [].
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Publication
10944212 | -
First Author: Seals DF
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion.
Volume: 97
Issue: 17
Pages: 9402-7
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Publication
9184222 | -
First Author: Cowles CR
Year: 1997
Journal: EMBO J
Title: Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component.
Volume: 16
Issue: 10
Pages: 2769-82
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Publication
9111041 | -
First Author: Nakamura N
Year: 1997
Journal: J Biol Chem
Title: Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae.
Volume: 272
Issue: 17
Pages: 11344-9
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Publication
12906858 | J:85218
First Author: Lin B
Year: 2003
Journal: Genomics
Title: Isolation and characterization of human and mouse WDR19,a novel WD-repeat protein exhibiting androgen-regulated expression in prostate epithelium.
Volume: 82
Issue: 3
Pages: 331-42
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Protein
F6ZLN8
Organism: Mus musculus/domesticus
Length: 964  
Fragment?: true
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Publication
11160821 | -
First Author: Darsow T
Year: 2001
Journal: Mol Biol Cell
Title: Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains.
Volume: 12
Issue: 1
Pages: 37-51
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Protein Domain
IPR000547 | Clathrin_H-chain/VPS_repeat
Type: Repeat
Description: Clathrin is a triskelion-shaped cytoplasmic protein that polymerises into a polyhedral lattice on intracellular membranes to form protein-coated membrane vesicles. Lattice formation induces the sorting of membrane proteins during endocytosis and organelle biogenesis by interacting with membrane-associated adaptor molecules. Clathrin functions as a trimer, and these trimers, or triskelions, are comprised of three legs joined by a central vertex. Each leg consists of one heavy chain and one light chain. The clathrin heavy-chain contains a 145-residue repeat that is present in seven copies [, ]. The clathrin heavy-chain repeat (CHCR) is also found in nonclathrin proteins such as Pep3, Pep5, Vam6, Vps41, and Vps8 from Saccharomyces cerevisiae and their orthologs from other eukaryotes [, , , ]. These proteins, like clathrins, are involved in vacuolar maintenance and protein sorting. The CHCR repeats in these proteins could mediate protein-protein interactions, or possibly represent clathrin-binding domains, or perform clathrin-like functions. CHCR repeats in the clathrin heavy chain, Saccharomyces cerevisiae Vamp2 and human Vamp6 have been implicated in homooligomerization, suggesting that this may be the primary function of this repeat.The CHCR repeat folds into an elongated right-handed superhelix coil of short α-helices []. Individual 'helix-turn-helix-loop' or helix hairpin units comprise the canonical repeat and stack along the superhelix axis to form a single extended domain. The canonical hairpin repeat of the clathrin superhelix resembles a tetratrico peptide repeat (TPR), but is shorter and lacks the characteristic spacing of the hydrophobic residues in TPRs.
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Protein
Q8R307
Organism: Mus musculus/domesticus
Length: 973  
Fragment?: false
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Protein
Q3UG80
Organism: Mus musculus/domesticus
Length: 974  
Fragment?: false
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Protein
Q3U7D9
Organism: Mus musculus/domesticus
Length: 613  
Fragment?: true
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Protein
Q3TS83
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
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Protein
Q6PES1
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
Q69ZI9
Organism: Mus musculus/domesticus
Length: 787  
Fragment?: true
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Protein
Q8BLK7
Organism: Mus musculus/domesticus
Length: 761  
Fragment?: false
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Protein
Q0P5W1
Organism: Mus musculus/domesticus
Length: 1427  
Fragment?: false
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Protein
Q5KU39
Organism: Mus musculus/domesticus
Length: 853  
Fragment?: false
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Protein
F8WI64
Organism: Mus musculus/domesticus
Length: 1399  
Fragment?: false
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Protein
D3YUP0
Organism: Mus musculus/domesticus
Length: 1429  
Fragment?: false
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Publication
10360576 | -
First Author: Ybe JA
Year: 1999
Journal: Nature
Title: Clathrin self-assembly is mediated by a tandemly repeated superhelix.
Volume: 399
Issue: 6734
Pages: 371-5
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Publication
17702618 | -
First Author: Young A
Year: 2007
Journal: Semin Cell Dev Biol
Title: Structural insights into the clathrin coat.
Volume: 18
Issue: 4
Pages: 448-58
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Publication
11448994 | -
First Author: Caplan S
Year: 2001
Journal: J Cell Biol
Title: Human Vam6p promotes lysosome clustering and fusion in vivo.
Volume: 154
Issue: 1
Pages: 109-22
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Protein
Q3UR70
Organism: Mus musculus/domesticus
Length: 860  
Fragment?: false
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Protein
Q8R5L3
Organism: Mus musculus/domesticus
Length: 886  
Fragment?: false
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Protein
Q3TJ98
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
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Protein
Q8K2I5
Organism: Mus musculus/domesticus
Length: 504  
Fragment?: true
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Protein
Q8BUJ2
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: true
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Protein
Q6ZQ51
Organism: Mus musculus/domesticus
Length: 889  
Fragment?: true
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Protein
Q3USV9
Organism: Mus musculus/domesticus
Length: 886  
Fragment?: false
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Protein
Q3TC98
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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Protein
Q8BY36
Organism: Mus musculus/domesticus
Length: 875  
Fragment?: false
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Protein
F6Z1R4
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Protein
Q3URK7
Organism: Mus musculus/domesticus
Length: 875  
Fragment?: false
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Protein
Q3UPJ3
Organism: Mus musculus/domesticus
Length: 983  
Fragment?: true
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Protein
Q5KU38
Organism: Mus musculus/domesticus
Length: 875  
Fragment?: false
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Protein
Q8C027
Organism: Mus musculus/domesticus
Length: 813  
Fragment?: false
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Protein
Q68FD5
Organism: Mus musculus/domesticus
Length: 1675  
Fragment?: false
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Protein
Q5SXR6
Organism: Mus musculus/domesticus
Length: 1679  
Fragment?: false
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Protein
Q80U89
Organism: Mus musculus/domesticus
Length: 1684  
Fragment?: true
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Protein
Q91W86
Organism: Mus musculus/domesticus
Length: 941  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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