Lamtor4 is a component of the Ragulator complex, a complex that functions as a guanine nucleotide exchange factor for the Rag GTPases that signal amino acid levels to mTORC1. The mTOR Complex 1 (mTORC1) pathway regulates cell growth in response to numerous cues. Lamtor4 is required for mTORC1 activation by amino acids []. The Rag-Ragulator complex also has functions independent of mTOR signaling; RagA and Lamtor4 are essential regulators of lysosomes in microglia [].
This entry represents the Ragulator complex protein LAMTOR2. The Ragulator complex consists of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 []. The Ragulator complex is involved in amino acid sensing and activation of the mTORC1 signalling pathway. The complex is activated by amino acids through a mechanism involving the lysosomal V-ATPase, and functions as a guanine nucleotide exchange factor activating the small GTPases Rag [], []. This entry also includes uncharacterised proteins from bacteria and archaea.
