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Search results 101 to 200 out of 254 for Iapp

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Type Details Score
Publication
10424881 | J:56760
First Author: Tingstedt JE
Year: 1999
Journal: J Histochem Cytochem
Title: Gastric amylin expression. Cellular identity and lack of requirement for the homeobox protein PDX-1. A study in normal and PDX-1-deficient animals with a cautionary note on antiserum evaluation.
Volume: 47
Issue: 8
Pages: 973-80
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Publication
21997794 | J:179025
First Author: Moon HS
Year: 2012
Journal: Diabetologia
Title: Amylin and leptin activate overlapping signalling pathways in an additive manner in mouse GT1-7 hypothalamic, Cā‚‚Cā‚ā‚‚ muscle and AML12 liver cell lines.
Volume: 55
Issue: 1
Pages: 215-25
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Publication
14970190 | J:88964
First Author: Dacquin R
Year: 2004
Journal: J Cell Biol
Title: Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo.
Volume: 164
Issue: 4
Pages: 509-14
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Publication
26655697 | J:235897
First Author: Li Z
Year: 2015
Journal: Cell Metab
Title: Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake.
Volume: 22
Issue: 6
Pages: 1059-67
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Publication
35963866 | J:328782
First Author: Meier DT
Year: 2022
Journal: Nat Commun
Title: Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing.
Volume: 13
Issue: 1
Pages: 4761
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Publication
29467172 | J:262098
First Author: Lutz TA
Year: 2018
Journal: Diabetes
Title: Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus.
Volume: 67
Issue: 5
Pages: 805-817
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Publication
34077719 | J:333282
First Author: Yoshihara C
Year: 2021
Journal: Cell Rep
Title: Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care.
Volume: 35
Issue: 9
Pages: 109204
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Publication
10078553 | J:64688
First Author: Arden SD
Year: 1999
Journal: Diabetes
Title: Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein.
Volume: 48
Issue: 3
Pages: 531-42
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Publication
18058910 | J:130423
First Author: Wang Q
Year: 2008
Journal: Dev Dyn
Title: Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum.
Volume: 237
Issue: 1
Pages: 51-61
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Publication
15031110 | J:92173
First Author: Heller RS
Year: 2004
Journal: Dev Biol
Title: The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity.
Volume: 268
Issue: 1
Pages: 123-34
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Publication
12921743 | J:84902
First Author: Hald J
Year: 2003
Journal: Dev Biol
Title: Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development.
Volume: 260
Issue: 2
Pages: 426-37
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Publication
11076772 | J:65594
First Author: Sander M
Year: 2000
Journal: Development
Title: Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.
Volume: 127
Issue: 24
Pages: 5533-40
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Publication
15944193 | J:98770
First Author: Henseleit KD
Year: 2005
Journal: Development
Title: NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas.
Volume: 132
Issue: 13
Pages: 3139-49
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Publication
17537793 | J:122518
First Author: Nelson SB
Year: 2007
Journal: Development
Title: The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.
Volume: 134
Issue: 13
Pages: 2491-500
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Publication
21343540 | J:172308
First Author: Stefan M
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.
Volume: 300
Issue: 5
Pages: E909-22
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Publication
18723011 | J:141017
First Author: Seymour PA
Year: 2008
Journal: Dev Biol
Title: A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation.
Volume: 323
Issue: 1
Pages: 19-30
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Publication
21880149 | J:176201
 
First Author: Kordowich S
Year: 2011
Journal: BMC Dev Biol
Title: Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage.
Volume: 11
Pages: 52
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Publication
17693256 | J:126780
First Author: Lee NK
Year: 2007
Journal: Cell
Title: Endocrine regulation of energy metabolism by the skeleton.
Volume: 130
Issue: 3
Pages: 456-69
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Publication
14729487 | J:87406
First Author: Wang J
Year: 2004
Journal: Dev Biol
Title: The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation.
Volume: 266
Issue: 1
Pages: 178-89
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Publication
9584121 | J:48576
First Author: Sussel L
Year: 1998
Journal: Development
Title: Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
Volume: 125
Issue: 12
Pages: 2213-21
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Publication
10825208 | J:62595
First Author: Jacquemin P
Year: 2000
Journal: Mol Cell Biol
Title: Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.
Volume: 20
Issue: 12
Pages: 4445-54
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Publication
16951258 | J:112173
First Author: Gierl MS
Year: 2006
Journal: Genes Dev
Title: The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells.
Volume: 20
Issue: 17
Pages: 2465-78
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Publication
26752640 | J:248949
First Author: Ejarque M
Year: 2016
Journal: PLoS One
Title: Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8).
Volume: 11
Issue: 1
Pages: e0146273
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Publication
22013016 | J:191410
First Author: Ohta Y
Year: 2011
Journal: Diabetes
Title: Convergence of the insulin and serotonin programs in the pancreatic Ī²-cell.
Volume: 60
Issue: 12
Pages: 3208-16
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Publication
23260145 | J:193325
First Author: Boj SF
Year: 2012
Journal: Cell
Title: Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Volume: 151
Issue: 7
Pages: 1595-607
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
29337308 | J:258335
First Author: Abedini A
Year: 2018
Journal: J Clin Invest
Title: RAGE binds preamyloid IAPP intermediates and mediates pancreatic Ī² cell proteotoxicity.
Volume: 128
Issue: 2
Pages: 682-698
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Publication
33007295 | J:301263
 
First Author: Chen HC
Year: 2020
Journal: Exp Neurol
Title: Interaction of human IAPP and AĪ²1-42 aggravated the AD-related pathology and impaired the cognition in mice.
Volume: 334
Pages: 113490
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Publication
30852627 | J:277679
First Author: Gurlo T
Year: 2019
Journal: Diabetologia
Title: Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes.
Volume: 62
Issue: 6
Pages: 1000-1010
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Strain
MGI:5498151 | B6.129P2-Iapp<tm1Sgm>/Kctt
Attribute String: congenic, mutant strain, targeted mutation
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Publication
26900721 | J:321105
First Author: Gurlo T
Year: 2016
Journal: Mol Endocrinol
Title: CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced Ī²-Cell Apoptosis.
Volume: 30
Issue: 4
Pages: 446-54
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Publication
19002432 | J:144761
First Author: Udayasankar J
Year: 2009
Journal: Diabetologia
Title: Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets.
Volume: 52
Issue: 1
Pages: 145-53
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Publication
33235246 | J:299713
First Author: Mucibabic M
Year: 2020
Journal: Sci Rep
Title: Ī±-Synuclein promotes IAPP fibril formation in vitro and Ī²-cell amyloid formation in vivo in mice.
Volume: 10
Issue: 1
Pages: 20438
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Publication
36917177 | J:335477
 
First Author: Albariqi MM
Year: 2023
Journal: J Clin Invest
Title: Human IAPP is a contributor to painful diabetic peripheral neuropathy.
Volume: 133
Issue: 8
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Publication
19352619 | J:150470
First Author: Hull RL
Year: 2009
Journal: Diabetologia
Title: Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress.
Volume: 52
Issue: 6
Pages: 1102-11
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Publication
24965964 | J:217001
First Author: Meier DT
Year: 2014
Journal: Diabetologia
Title: Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice.
Volume: 57
Issue: 9
Pages: 1884-8
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MP Term
MP:0014124 | increased amylin secretion
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MP Term
MP:0014123 | abnormal amylin secretion
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MP Term
MP:0014125 | decreased amylin secretion
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GO Term
GO:0034231 | islet amyloid polypeptide processing
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Allele
Iapp<em1Smoc> | MGI:7290291
Name: islet amyloid polypeptide; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Tg(Ins2-Iapp)6Soel | MGI:3771295
Name: transgene insertion 6, Walter C Soeller
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Ins2-IAPP)RHFSoel | MGI:2157065
Name: transgene insertion RHF, Walter C Soeller
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
32229246 | J:321040
 
First Author: RodrĆ­guez-Comas J
Year: 2020
Journal: Mol Metab
Title: Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and Ī²-cell dysfunction.
Volume: 37
Pages: 100984
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Genotype
Genotype
Symbol: Tg(Ins2-Iapp)6Soel/Tg(Ins2-Iapp)6Soel
Background: involves: FVB/N
Zygosity: hm
Has Mutant Allele: true
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Publication
20042670 | J:156597
First Author: Gurlo T
Year: 2010
Journal: Am J Pathol
Title: Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway.
Volume: 176
Issue: 2
Pages: 861-9
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Publication
27812546 | J:327487
First Author: Gurlo T
Year: 2016
Journal: JCI Insight
Title: Ī² Cell-specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity.
Volume: 1
Issue: 18
Pages: e89590
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Publication
28337562 | J:336953
First Author: Alcarraz-VizƔn G
Year: 2017
Journal: Cell Mol Life Sci
Title: BACE2 suppression promotes Ī²-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression.
Volume: 74
Issue: 15
Pages: 2827-2838
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Publication
17911343 | J:130022
First Author: Huang CJ
Year: 2007
Journal: Am J Physiol Endocrinol Metab
Title: Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.
Volume: 293
Issue: 6
Pages: E1656-62
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Publication
34554282 | J:322752
First Author: Blencowe M
Year: 2022
Journal: Diabetologia
Title: IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes.
Volume: 65
Issue: 1
Pages: 173-187
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Publication
7958499 | J:263024
First Author: D'Alessio DA
Year: 1994
Journal: Diabetes
Title: Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.
Volume: 43
Issue: 12
Pages: 1457-61
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Publication
17259373 | J:121959
First Author: Zraika S
Year: 2007
Journal: Diabetes
Title: Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis.
Volume: 56
Issue: 2
Pages: 304-10
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Publication
27379014 | J:289578
 
First Author: Krishnamurthy PK
Year: 2016
Journal: Front Endocrinol (Lausanne)
Title: Sex and Immunogen-Specific Benefits of Immunotherapy Targeting Islet Amyloid Polypeptide in Transgenic and Wild-Type Mice.
Volume: 7
Pages: 62
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Allele
Tg(Iapp-cre)1Oyak | MGI:7434726
Name: transgene insertion 1, Kumi O Kuroda
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
24222351 | J:229066
First Author: Westwell-Roper CY
Year: 2014
Journal: Diabetes
Title: Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1Ī² production and Ī²-cell dysfunction.
Volume: 63
Issue: 5
Pages: 1698-711
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Publication
20814419 | J:186330
First Author: Rivera JF
Year: 2011
Journal: Cell Death Differ
Title: Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic Ī²-cells: protective role of p62-positive cytoplasmic inclusions.
Volume: 18
Issue: 3
Pages: 415-26
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Strain
MGI:3783728 | FVB/N-Tg(Ins2-IAPP)RHFSoel/J
Attribute String: transgenic, coisogenic
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Publication
36922503 | J:335026
First Author: Fukunaka A
Year: 2023
Journal: Sci Rep
Title: Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model.
Volume: 13
Issue: 1
Pages: 3484
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Publication
28821639 | J:256410
First Author: Montane J
Year: 2017
Journal: FASEB J
Title: Amyloid-induced Ī²-cell dysfunction and islet inflammation are ameliorated by 4-phenylbutyrate (PBA) treatment.
Volume: 31
Issue: 12
Pages: 5296-5306
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Publication
29348618 | J:265794
First Author: Franko A
Year: 2018
Journal: Sci Rep
Title: Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice.
Volume: 8
Issue: 1
Pages: 1116
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Publication
26607804 | J:236354
 
First Author: Montane J
Year: 2016
Journal: Mol Cell Endocrinol
Title: Protein disulfide isomerase ameliorates Ī²-cell dysfunction in pancreatic islets overexpressing human islet amyloid polypeptide.
Volume: 420
Pages: 57-65
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Publication
29070797 | J:255385
First Author: Bram Y
Year: 2017
Journal: Sci Rep
Title: Active Immunization Against hIAPP Oligomers Ameliorates the Diabetes- Associated Phenotype in a Transgenic Mice Model.
Volume: 7
Issue: 1
Pages: 14031
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Allele
Iapp<tm1(IAPP)Nole> | MGI:7620149
Name: islet amyloid polypeptide; targeted mutation 1, Norman L Eberhardt
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Ins2-IAPP)RHFSoel/Tg(Ins2-IAPP)RHFSoel
Background: involves: FVB/N
Zygosity: hm
Has Mutant Allele: true
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Publication
21484213 | J:173776
First Author: Aston-Mourney K
Year: 2011
Journal: Diabetologia
Title: Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.
Volume: 54
Issue: 7
Pages: 1756-65
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Publication
25491100 | J:219633
First Author: Westwell-Roper CY
Year: 2015
Journal: Diabetologia
Title: IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice.
Volume: 58
Issue: 3
Pages: 575-85
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Publication
35871651 | J:345084
First Author: Castillo JJ
Year: 2022
Journal: Diabetologia
Title: Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice.
Volume: 65
Issue: 10
Pages: 1687-1700
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Allele
Tg(Ins2-IAPP)25-3Rpa | MGI:6188081
Name: transgene insertion 25-3, Richard D Palmiter
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
34088954 | J:321042
First Author: de Pablo S
Year: 2021
Journal: Sci Rep
Title: 4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity.
Volume: 11
Issue: 1
Pages: 11878
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Allele
Iapp<tm2(IAPP*S53G)Nole> | MGI:7620150
Name: islet amyloid polypeptide; targeted mutation 2, Norman L Eberhardt
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Iapp-cre)1Oyak/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Publication
8622964 | J:108871
First Author: Verchere CB
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.
Volume: 93
Issue: 8
Pages: 3492-6
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Publication
27999871 | J:240112
First Author: Courtade JA
Year: 2017
Journal: Diabetologia
Title: Loss of prohormone convertase 2 promotes beta cell dysfunction in a rodent transplant model expressing human pro-islet amyloid polypeptide.
Volume: 60
Issue: 3
Pages: 453-463
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Publication
28808140 | J:256411
First Author: Wijesekara N
Year: 2017
Journal: FASEB J
Title: Amyloid-Ī² and islet amyloid pathologies link Alzheimer's disease and type 2 diabetes in a transgenic model.
Volume: 31
Issue: 12
Pages: 5409-5418
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Publication
26970755 | J:234723
First Author: Wijesekara N
Year: 2016
Journal: Diabetologia
Title: ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice.
Volume: 59
Issue: 6
Pages: 1242-6
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Publication
33797777 | J:321044
First Author: Wijesekara N
Year: 2021
Journal: J Pathol
Title: Combination of human tau and islet amyloid polypeptide exacerbates metabolic dysfunction in transgenic mice.
Volume: 254
Issue: 3
Pages: 244-253
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