Islet cell autoantigen 69kDa (ICA69) or islet cell autoantigen 1 was identified with a group of type 1 diabetes-related islet autoantigens []. ICA69 is enriched in the Golgi complex, and its N-terminal half contains a BAR-domain []. ICA69 forms heteromeric BAR-domain complexes with another cytosolic lipid-binding protein, PICK1. Together they are key regulators of the formation and maturation of insulin granules [].
This entry represents a C-terminal domain found in islet cell autoantigen Ica1. Ica1 has been identified as an islet cell autoantigen in type I diabetes mellitus []. Its precise function is unknown, though it may play a role in neurotransmitter secretion [].
Islet cell autoantigen 1 (Ica1) and its Caenorhabditis elegans homologue, Ric19 (resistance to inhibitors of cholinesterase protein 19), may play a role in neurotransmitter secretion [].This entry includes Ica1 and homologues, and also proteins known as Ica1-like, which are found in mammals and whose function has not been described.
